| Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses WY Chen, DH Wang, RWC Yen, J Luo, W Gu, SB Baylin Cell 123 (3), 437-448, 2005 | 796 | 2005 |
| Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib L Li, L Wang, L Li, Z Wang, Y Ho, T McDonald, TL Holyoake, WY Chen, ... Cancer cell 21 (2), 266-281, 2012 | 452 | 2012 |
| Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase WY Chen, EC Bailey, SL McCune, JY Dong, TM Townes Proceedings of the National Academy of Sciences 94 (11), 5798-5803, 1997 | 337 | 1997 |
| NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response B Wang, MK Hasan, E Alvarado, H Yuan, H Wu, WY Chen Oncogene 30 (8), 907-921, 2011 | 299 | 2011 |
| Sorting out functions of sirtuins in cancer M Roth, WY Chen Oncogene 33 (13), 1609-1620, 2014 | 276 | 2014 |
| Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors WY Chen, X Zeng, MG Carter, CN Morrell, RW Chiu Yen, M Esteller, ... Nature genetics 33 (2), 197-202, 2003 | 271 | 2003 |
| SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells L Li, T Osdal, Y Ho, S Chun, T McDonald, P Agarwal, A Lin, S Chu, J Qi, ... Cell stem cell 15 (4), 431-446, 2014 | 236 | 2014 |
| The emerging and diverse roles of sirtuins in cancer: a clinical perspective H Yuan, L Su, WY Chen OncoTargets and therapy, 1399-1416, 2013 | 211 | 2013 |
| Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis WY Chen, TK Cooper, CA Zahnow, M Overholtzer, Z Zhao, M Ladanyi, ... Cancer Cell 6 (4), 387-398, 2004 | 208 | 2004 |
| Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis H Yuan, Z Wang, L Li, H Zhang, H Modi, D Horne, R Bhatia, WY Chen Blood, The Journal of the American Society of Hematology 119 (8), 1904-1914, 2012 | 204 | 2012 |
| Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation WY Chen, TM Townes Proceedings of the National Academy of Sciences 97 (1), 377-382, 2000 | 156 | 2000 |
| SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells Z Wang, H Yuan, M Roth, JM Stark, R Bhatia, WY Chen Oncogene 32 (5), 589-598, 2013 | 118 | 2013 |
| Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling S Nam, A Scuto, F Yang, WY Chen, S Park, HS Yoo, H Konig, R Bhatia, ... Molecular oncology 6 (3), 276-283, 2012 | 89 | 2012 |
| Emerging roles of SIRT1 in cancer drug resistance Z Wang, WY Chen Genes & cancer 4 (3-4), 82-90, 2013 | 88 | 2013 |
| An emerging trend of rapid increase of leukemia but not all cancers in the aging population in the United States T Hao, M Li-Talley, A Buck, WY Chen Scientific reports 9 (1), 12070, 2019 | 87 | 2019 |
| Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice WY Chen, X Wu, DN Levasseur, H Liu, L Lai, JC Kappes, TM Townes Stem Cells 18 (5), 352-359, 2000 | 80 | 2000 |
| Aberrant gene silencing in tumor progression: implications for control of cancer SB Baylin, WY Chen Cold Spring Harbor symposia on quantitative biology 70, 427-433, 2005 | 75 | 2005 |
| VISFATIN (NAMPT) improves in vitro IGF1-induced steroidogenesis and IGF1 receptor signaling through SIRT1 in bovine granulosa cells M Reverchon, C Rame, A Bunel, W Chen, P Froment, J Dupont Biology of reproduction 94 (3), 54, 1-13, 2016 | 71 | 2016 |
| BCR-ABL Gene Expression Is Required for Its Mutations in a Novel KCL-22 Cell Culture Model for Acquired Resistance of Chronic Myelogenous Leukemia 2 H Yuan, Z Wang, C Gao, W Chen, Q Huang, JK Yee, R Bhatia, WY Chen Journal of biological chemistry 285 (7), 5085-5096, 2010 | 70 | 2010 |
| Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous … S Chakraborty, JM Stark, CL Sun, H Modi, WY Chen, TR O'Connor, ... Blood, The Journal of the American Society of Hematology 119 (26), 6187-6197, 2012 | 53 | 2012 |
