Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt RR Katreddy, LR Bollu, F Su, N Xian, S Srivastava, R Thomas, Y Dai, ... Oncogenesis 7 (1), 5, 2018 | 34 | 2018 |
Kinase-inactivated EGFR is required for the survival of wild-type EGFR-expressing cancer cells treated with tyrosine kinase inhibitors R Thomas, S Srivastava, RR Katreddy, J Sobieski, Z Weihua International journal of molecular sciences 20 (10), 2515, 2019 | 19 | 2019 |
Novel liver X receptor ligand GAC0001E5 disrupts glutamine metabolism and induces oxidative stress in pancreatic cancer cells S Srivastava, S Widmann, C Ho, D Nguyen, A Nguyen, A Premaratne, ... International Journal of Molecular Sciences 21 (24), 9622, 2020 | 17 | 2020 |
Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity CYL Husna Karaboga, Wentao Huang, Shivangi Srivastava, Scott Widmann ... ACS Chemical Biology, 2020 | 14 | 2020 |
A novel liver X receptor inverse agonist impairs cholesterol and phospholipid metabolism and induces apoptosis and necroptosis in pancreatic ductal adenocarcinoma cells S Widmann, S Srivastava, CY Lin Receptors 2 (1), 34-46, 2023 | 5 | 2023 |
Abstract C53: Liver X receptor ligand targets glutamine metabolism in pancreatic cancer S Srivastava, S Widmann, CY Lin Cancer Research 79 (24_Supplement), C53-C53, 2019 | | 2019 |