(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD CY Chen, YH Weng, KY Chien, KJ Lin, TH Yeh, YP Cheng, CS Lu, ... Cell Death & Differentiation 19 (10), 1623-1633, 2012 | 205 | 2012 |
(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse JS Chou, CY Chen, YL Chen, YH Weng, TH Yeh, CS Lu, YM Chang, ... Neurobiology of disease 68, 190-199, 2014 | 70 | 2014 |
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course N Tayebi, L Parisiadou, B Berhe, AN Gonzalez, J Serra-Vinardell, ... Molecular genetics and metabolism 122 (4), 198-208, 2017 | 34 | 2017 |
Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations C Chen, G Soto, V Dumrongprechachan, N Bannon, S Kang, ... Elife 9, e58997, 2020 | 29 | 2020 |
(R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model YH Weng, CY Chen, KJ Lin, YL Chen, TH Yeh, T Hsiao, J Chen, CS Lu, ... Experimental Neurology 275, 104-115, 2016 | 25 | 2016 |
NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity HJ Kang, HY Song, MA Ahmed, Y Guo, M Zhang, C Chen, M Cristofanilli, ... Free Radical Biology and Medicine 126, 358-371, 2018 | 12 | 2018 |
R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations HS Xenias, C Chen, S Kang, S Cherian, X Situ, B Shanmugasundaram, ... Communications biology 5 (1), 1211, 2022 | 4 | 2022 |
Pathogenic LRRK2 R1441C mutation is associated with striatal alterations HS Xenias, C Chen, S Kang, S Cherian, X Situ, B Shanmugasundaram, ... bioRxiv, 2020.03. 11.986455, 2020 | 4 | 2020 |
Closing the structure-to-function gap for LRRK2 V Tokars, C Chen, L Parisiadou Trends in Biochemical Sciences 47 (3), 187-188, 2022 | 3 | 2022 |
LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton G Tombesi, S Kompella, G Favetta, C Chen, Y Zhao, M Sevegnani, ... bioRxiv, 2022.10. 31.514622, 2022 | | 2022 |
Viral-mediated short-hairpin RNA knockdown C Chen, L Parisiadou | | 2022 |
Behavioral tests in rodents coupled with dopamine signaling manipulations C Chen, L Parisiadou | | 2022 |
Fractionation of synaptosomes C Chen, C Smith, L Parisiadou | | 2022 |
Protocol for mixed cortical striatal cell culture C Chen, C Smith, L Parisiadou | | 2022 |
APEX2 labelling and screening for biotinylated proteins by proteomics C Chen, C Smith, L Parisiadou | | 2022 |
REVEALING THE MOLECULAR MECHANISM UNDER GENETIC VARIANTS LOCI RS34767465 IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. H Zhang, T De, C Chen, L Parisiadou, M Perera CLINICAL PHARMACOLOGY & THERAPEUTICS 105, S116-S116, 2019 | | 2019 |