| ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death J Han, SH Back, J Hur, YH Lin, R Gildersleeve, J Shan, CL Yuan, ... Nature cell biology 15 (5), 481-490, 2013 | 1622 | 2013 |
| The role of ER stress in lipid metabolism and lipotoxicity J Han, RJ Kaufman Journal of lipid research 57 (8), 1329-1338, 2016 | 562 | 2016 |
| Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in β cells SH Back, D Scheuner, J Han, B Song, M Ribick, J Wang, RD Gildersleeve, ... Cell metabolism 10 (1), 13-26, 2009 | 397 | 2009 |
| IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis S Wang, Z Chen, V Lam, J Han, J Hassler, BN Finck, NO Davidson, ... Cell metabolism 16 (4), 473-486, 2012 | 231 | 2012 |
| Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis YS Lee, S Shin, T Shigihara, E Hahm, MJ Liu, J Han, JW Yoon, HS Jun Diabetes 56 (6), 1671-1679, 2007 | 207 | 2007 |
| The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β‐cells RJ Kaufman, SH Back, B Song, J Han, J Hassler Diabetes, Obesity and Metabolism 12, 99-107, 2010 | 156 | 2010 |
| The IRE1α/XBP1s pathway is essential for the glucose response and protection of β cells JR Hassler, DL Scheuner, S Wang, J Han, VK Kodali, P Li, J Nguyen, ... PLoS biology 13 (10), e1002277, 2015 | 154 | 2015 |
| Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response N Hiramatsu, C Messah, J Han, MM LaVail, RJ Kaufman, JH Lin Molecular biology of the cell 25 (9), 1411-1420, 2014 | 134 | 2014 |
| Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus J Yong, JD Johnson, P Arvan, J Han, RJ Kaufman Nature Reviews Endocrinology 17 (8), 455-467, 2021 | 131 | 2021 |
| ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice J Han, R Murthy, B Wood, B Song, S Wang, B Sun, H Malhi, RJ Kaufman Diabetologia 56, 911-924, 2013 | 125 | 2013 |
| A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux D Krokowski, J Han, M Saikia, M Majumder, CL Yuan, BJ Guan, ... Journal of Biological Chemistry 288 (24), 17202-17213, 2013 | 119 | 2013 |
| Physiological/pathological ramifications of transcription factors in the unfolded protein response J Han, RJ Kaufman Genes & development 31 (14), 1417-1438, 2017 | 109 | 2017 |
| RNA surveillance is required for endoplasmic reticulum homeostasis K Sakaki, S Yoshina, X Shen, J Han, MR DeSantis, M Xiong, S Mitani, ... Proceedings of the National Academy of Sciences 109 (21), 8079-8084, 2012 | 101 | 2012 |
| Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes SH Back, SW Kang, J Han, HT Chung Experimental diabetes research 2012, 2012 | 98 | 2012 |
| Effect of p38 mitogen-activated protein kinase on the replication of encephalomyocarditis virus K Hirasawa, A Kim, HS Han, J Han, HS Jun, JW Yoon Journal of virology 77 (10), 5649-5656, 2003 | 98 | 2003 |
| Selective transcriptional regulations in the human liver cell by hepatitis B viral X protein J Han, HY Yoo, BH Choi, HM Rho Biochemical and biophysical research communications 272 (2), 525-530, 2000 | 91 | 2000 |
| C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis H Malhi, EM Kropp, VF Clavo, CR Kobrossi, JS Han, AS Mauer, J Yong, ... Journal of Biological Chemistry 288 (26), 18624-18642, 2013 | 87 | 2013 |
| Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase HS Jun, YH Chung, J Han, A Kim, S Yoo, R Sherwin, JW Yoon Diabetologia 45, 668-676, 2002 | 80 | 2002 |
| ER stress induces cell cycle arrest at the G2/M phase through eIF2α phosphorylation and GADD45α D Lee, D Hokinson, S Park, R Elvira, F Kusuma, JM Lee, M Yun, SG Lee, ... International journal of molecular sciences 20 (24), 6309, 2019 | 77 | 2019 |
| Gamma interferon paradoxically inhibits the development of diabetes in the NOD mouse DO Sobel, J Han, J Williams, JW Yoon, HS Jun, B Ahvazi Journal of autoimmunity 19 (3), 129-137, 2002 | 69 | 2002 |
Maureen A SartorProfessor of Bioinformatics, University of MichiganVerified email at umich.edu
