Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational … F Guapo, L Strasser, S Millán-Martín, I Anderson, J Bones Journal of pharmaceutical and biomedical analysis 207, 114427, 2022 | 19 | 2022 |
Proteomic landscape of adeno-associated virus (AAV)-producing HEK293 cells L Strasser, S Boi, F Guapo, N Donohue, N Barron, A Rainbow-Fletcher, ... International journal of molecular sciences 22 (21), 11499, 2021 | 16 | 2021 |
A native mass spectrometry-based assay for rapid assessment of the empty: full capsid ratio in adeno-associated virus gene therapy products L Strasser, TE Morgan, F Guapo, F Füssl, D Forsey, I Anderson, J Bones Analytical Chemistry 93 (38), 12817-12821, 2021 | 15 | 2021 |
SP3-based host cell protein monitoring in AAV-based gene therapy products using LC-MS/MS J Smith, L Strasser, F Guapo, SG Milian, RO Snyder, J Bones European Journal of Pharmaceutics and Biopharmaceutics 189, 276-280, 2023 | 3 | 2023 |
Mass spectrometry friendly pH-gradient anion exchange chromatography for the separation of full and empty adeno-associated virus (AAV) capsids F Guapo, F Füssl, L Strasser, J Bones Analytical Methods 15 (43), 5788-5792, 2023 | 2 | 2023 |
Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins J Smith, F Guapo, L Strasser, S Millán-Martín, SG Milian, RO Snyder, ... Journal of Proteome Research 23 (1), 161-174, 2023 | 1 | 2023 |
A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product … F Guapo, N Donohue, L Strasser, S Boi, F Füssl, A Rainbow-Fletcher, ... International Journal of Molecular Sciences 25 (5), 2785, 2024 | | 2024 |
Annotation of the non-canonical translatome reveals that CHO cell microproteins are a new class of mAb drug product impurity M Castro-Rivadeneyra, I Tzani, P Kelly, L Strasser, F Guapo, C Tierney, ... | | 2022 |
Found in translation: Microproteins are a new class of potential host cell impurity in mAb drug products M Castro-Rivadeneyra, I Tzani, P Kelly, L Strasser, F Guapo, C Tierney, ... bioRxiv, 2022.01. 20.475618, 2022 | | 2022 |
A native mass spectrometry-based assay for rapid assessment of the empty/full capsid ratio in AAV gene therapy products L Strasser, TE Morgan, F Guapo, F Füssl, D Forsey, I Anderson, J Bones bioRxiv, 2021.07. 06.451264, 2021 | | 2021 |