| CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for … D Mosqueira, I Mannhardt, JR Bhagwan, K Lis-Slimak, P Katili, E Scott, ... European heart journal 39 (43), 3879-3892, 2018 | 215 | 2018 |
| Isogenic pairs of hiPSC-CMs with hypertrophic cardiomyopathy/LVNC-associated ACTC1 E99K mutation unveil differential functional deficits JGW Smith, T Owen, JR Bhagwan, D Mosqueira, E Scott, I Mannhardt, ... Stem cell reports 11 (5), 1226-1243, 2018 | 63 | 2018 |
| Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics JR Bhagwan, D Mosqueira, K Chairez-Cantu, I Mannhardt, SE Bodbin, ... Journal of molecular and cellular cardiology 145, 43-53, 2020 | 54 | 2020 |
| Modeling hypertrophic cardiomyopathy: mechanistic insights and pharmacological intervention D Mosqueira, JGW Smith, JR Bhagwan, C Denning Trends in molecular medicine 25 (9), 775-790, 2019 | 48 | 2019 |
| Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells A Kondrashov, M Duc Hoang, JGW Smith, JR Bhagwan, G Duncan, ... Stem cells and development 27 (6), 391-404, 2018 | 34 | 2018 |
| Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour JR Bhagwan, E Collins, D Mosqueira, M Bakar, BB Johnson, A Thompson, ... F1000Research 8, 2019 | 33 | 2019 |
| Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour. figshare. Collection. 2019 J Bhagwan, E Collins, D Mosqueira | 12 | |
| CRISPR/Cas9 gene editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy D Mosqueira, I Mannhardt, JR Bhagwan, K Lis-Slimak, P Katili, E Scott, ... Human Gene Therapy 29 (12), A93-A94, 2018 | 3 | 2018 |
| Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug … B Lickiss, J Hunker, J Bhagwan, P Linder, U Thomas, H Lotay, ... Journal of Pharmacological and Toxicological Methods, 107529, 2024 | | 2024 |
| Isogenic pairs of patient-derived hiPSC-CMs with an apical hypertrophic cardiomyopathy/left ventricular non-compaction-associated ACTC1 E99K mutation unveil differential … TJ Owen, JS Smith, JR Bhagwan, D Mosqueira, E Scott, I Mannhardt, ... HUMAN GENE THERAPY 30 (2), A7-A8, 2019 | | 2019 |
| British Society for Gene and Cell Therapy Autumn Conference Friday 23 November 2018 Regent's University Conference Centre, London, UK Abstracts C Denning HUMAN GENE THERAPY 30 (2), A2-A2, 2019 | | 2019 |
| Changing the Face of Modern Medicine: Stem Cell and Gene Therapy Organized Jointly by the European Society of Gene & Cell Therapy (ESGCT), International Society for Stem Cell … KM Champion, P Albertini, I Visigalli, F Cecere, N Carriglio, ... Human Gene Therapy 29 (12), A1-A169, 2018 | | 2018 |
| CRISPR-Cas9 gene targeting of human induced pluripotent stem cells to generate a palette of optical reporter cell lines towards investigating hypertrophic cardiomyopathy JR Bhagwan University of Nottingham, 2018 | | 2018 |
| British Society for Gene and Cell Therapy Annual Conference Glasgow9–11th June 2015Conference Abstracts D Ando, AJ Thrasher, N Cartier, C Cowan, K Yusa, T Cathomen, D Corey, ... Human Gene Therapy 26 (9), A1-A36, 2015 | | 2015 |
| Targeted gene editing of human induced pluripotent stem cells using CRISPR-Cas9 to generate calcium reporter lines to investigate cardiomyopathies J Bhagwan, J Smith, G Duncan, V Borgdorff, C Denning HUMAN GENE THERAPY 26 (9), A17-A18, 2015 | | 2015 |
| harbour [version 1; peer review: awaiting peer review] JR Bhagwan, E Collins, D Mosqueira, M Bakar, BB Johnson, A Thompson, ... locus 1000, 2019, 1911 | | 1911 |
| Variable expression and silencing of CRISPR-Cas9 targete d transgenes identifies the AAVS1 locus as not an entirely saf e harbour [version 1; peer review: 1 approved, 1 not … JR Bhagwan, E Collins, D Mosqueira, M Bakar, BB Johnson, A Thompson, ... | | |
| Supplementary Material Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics JR Bhagwan, D Mosqueira, K Chairez-Cantu, I Mannhardt, SE Bodbin, ... | | |
