| Structural basis for allosteric PARP-1 retention on DNA breaks L Zandarashvili, MF Langelier, UK Velagapudi, MA Hancock, JD Steffen, ... Science 368 (6486), eaax6367, 2020 | 236 | 2020 |
| Design and synthesis of poly (ADP-ribose) polymerase inhibitors: impact of adenosine pocket-binding motif appendage to the 3-oxo-2, 3-dihydrobenzofuran-7-carboxamide on potency … UK Velagapudi, MF Langelier, C Delgado-Martin, ME Diolaiti, S Bakker, ... Journal of medicinal chemistry 62 (11), 5330-5357, 2019 | 35 | 2019 |
| Comprehensive synthesis of amino acid-derived thiazole peptidomimetic analogues to understand the enigmatic drug/substrate-binding site of P-glycoprotein BA Patel, B Abel, AM Barbuti, UK Velagapudi, ZS Chen, SV Ambudkar, ... Journal of medicinal chemistry 61 (3), 834-864, 2018 | 27 | 2018 |
| Chemical Space Exploration around Thieno[3,2-d]pyrimidin-4(3H)-one Scaffold Led to a Novel Class of Highly Active Clostridium difficile Inhibitors X Shao, A AbdelKhalek, NS Abutaleb, UK Velagapudi, S Yoganathan, ... Journal of medicinal chemistry 62 (21), 9772-9791, 2019 | 25 | 2019 |
| Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020) UK Velagapudi, BA Patel, X Shao, SK Pathak, DV Ferraris, TT Talele Expert Opinion on Therapeutic Patents 31 (7), 609-623, 2021 | 14 | 2021 |
| 2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function M Wang, AG Gauthier, TP Kennedy, H Wang, UK Velagapudi, TT Talele, ... Molecular Medicine 27, 1-17, 2021 | 5 | 2021 |
| Synthesis of 2, 3-dihydrobenzo [b][1, 4] dioxine-5-carboxamide and 3-oxo-3, 4-dihydrobenzo [b][1, 4] oxazine-8-carboxamide derivatives as PARP1 inhibitors X Shao, S Pak, UK Velagapudi, S Gobbooru, SS Kommaraju, WK Low, ... Bioorganic chemistry 102, 104075, 2020 | 5 | 2020 |
| The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions M Beaury, UK Velagapudi, S Weber, C Soto, TT Talele, DB Nichols Virus genes 53, 522-531, 2017 | 3 | 2017 |
| Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks UK Velagapudi, É Rouleau-Turcotte, R Billur, X Shao, M Patil, BE Black, ... Biochemical Journal 481 (6), 437-460, 2024 | | 2024 |
| Correction to: 2‑O, 3‑O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1‑compromised macrophage function M Wang, AG Gauthier, TP Kennedy, H Wang, UK Velagapudi, TT Talele, ... Molecular Medicine 27, 1-1, 2021 | | 2021 |
| Synthesis and evaluation of 2, 3-dihydrobenzofuran-3 (2H)-one-7-carboxamide derivatives as poly (ADP-ribose) polymerase-1 inhibitors U Kiran, A Bhatt, T Talele ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
| Identification and optimization of 2, 3-dihydrobenzo [b][1, 4] dioxine-5-carboxamide as PARP-1 inhibitors X Shao, S Pak, B Patel, UK Velagapudi, T Talele ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
xuwei shaoScientist II, Pace analytical life sciencesVerified email at pacelabs.com
