| Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity JA Carozza, V Böhnert, KC Nguyen, G Skariah, KE Shaw, JA Brown, ... Nature Cancer 1 (2), 184-196, 2020 | 204 | 2020 |
| LRRC8A: C/E heteromeric channels are ubiquitous transporters of cGAMP LJ Lahey, RE Mardjuki, X Wen, GT Hess, C Ritchie, JA Carozza, ... Molecular cell 80 (4), 578-591. e5, 2020 | 117 | 2020 |
| β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ... Scientific reports 6 (1), 36010, 2016 | 95 | 2016 |
| Structure-aided development of small-molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP JA Carozza, JA Brown, V Böhnert, D Fernandez, Y AlSaif, RE Mardjuki, ... Cell chemical biology 27 (11), 1347-1358. e5, 2020 | 74 | 2020 |
| Biochemistry, cell biology, and pathophysiology of the innate immune cGAS–cGAMP–STING pathway C Ritchie, JA Carozza, L Li Annual Review of Biochemistry 91, 599-628, 2022 | 46 | 2022 |
| Real-time intrinsic fluorescence visualization and sizing of proteins and protein complexes in microfluidic devices PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, ... Analytical chemistry 90 (6), 3849-3855, 2018 | 45 | 2018 |
| ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling JA Carozza, AF Cordova, JA Brown, Y AlSaif, V Böhnert, X Cao, ... Proceedings of the National Academy of Sciences 119 (21), e2119189119, 2022 | 44 | 2022 |
| Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples RE Mardjuki, JA Carozza, L Li Journal of Biological Chemistry 295 (15), 4881-4892, 2020 | 22 | 2020 |
| Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1 JA Carozza, V Böhnert, KC Nguyen, G Skariah, KE Shaw, JA Brown, ... BioRxiv, 539312, 2019 | 21 | 2019 |
| The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, ... Proceedings of the National Academy of Sciences 118 (38), e2108790118, 2021 | 18 | 2021 |
| The LRRC8A: C heteromeric channel is a cGAMP transporter and the dominant cGAMP importer in human vasculature cells LJ Lahey, X Wen, RE Mardjuki, V Böhnert, C Ritchie, JA Carozza, ... BioRxiv, 2020.02. 13.948273, 2020 | 12 | 2020 |
| Bö hnert JA Carozza, AF Cordova, JA Brown, Y AlSaif V., Cao, X., Mardjuki, RE, Skariah, G., Fernandez, D., and Li, L, 2022 | 6 | 2022 |
| A cGAMP-containing hydrogel for prolonged SARS-CoV-2 RBD subunit vaccine exposure induces a broad and potent humoral response EC Gale, LJ Lahey, V Böhnert, AE Powell, BS Ou, JA Carozza, L Li, ... bioRxiv, 2021.07. 03.451025, 2021 | 6 | 2021 |
| Discovery of VH domains that allosterically inhibit ENPP1 PE Solomon, CJ Bracken, JA Carozza, H Wang, EP Young, A Wellner, ... Nature Chemical Biology 20 (1), 30-41, 2024 | 4 | 2024 |
| Identification of extracellular membrane protein ENPP3 as a major cGAMP hydrolase, cementing cGAMP's role as an immunotransmitter R Mardjuki, S Wang, J Carozza, G Abhiraman, X Lyu, L Li bioRxiv, 2024.01. 12.575449, 2024 | 2 | 2024 |
| ENPP1 inhibitors and their use for the treatment of cancer L Li, M Smith, KE Shaw, JA Carozza, V Boehnert US Patent 11,707,471, 2023 | 1 | 2023 |
| Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1 JA Carozza, AF Cordova, Y AlSaif, V Böhnert, G Skariah, L Li bioRxiv, 2021.05. 04.442665, 2021 | 1 | 2021 |
| Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint R Mardjuki, S Wang, J Carozza, B Zirak, V Subramanyam, G Abhiraman, ... Cell Reports, 2024 | | 2024 |
| ENPP1 Inhibitors and Their Use for the Treatment of Cancer L Li, M Smith, KE Shaw, JA Carozza, V Boehnert US Patent App. 18/197,877, 2023 | | 2023 |
| ENPP1 inhibitors and their use for the treatment of cancer L Li, M Smith, KE Shaw, JA Carozza, V Boehnert US Patent 11,701,371, 2023 | | 2023 |
