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Jian Xiong
Jian Xiong
Sr. Scientist at Merck
Verified email at merck.com
Title
Cited by
Cited by
Year
A formulation development approach to identify and select stable ultra–high-concentration monoclonal antibody formulations with reduced viscosities
N Whitaker, J Xiong, SE Pace, V Kumar, CR Middaugh, SB Joshi, ...
Journal of pharmaceutical sciences 106 (11), 3230-3241, 2017
672017
Development of spirulina for the manufacture and oral delivery of protein therapeutics
BW Jester, H Zhao, M Gewe, T Adame, L Perruzza, DT Bolick, J Agosti, ...
Nature Biotechnology 40 (6), 956-964, 2022
662022
Preformulation characterization and stability assessments of secretory IgA monoclonal antibodies as potential candidates for passive immunization by oral administration
Y Hu, OS Kumru, J Xiong, LR Antunez, J Hickey, Y Wang, L Cavacini, ...
Journal of Pharmaceutical Sciences 109 (1), 407-421, 2020
262020
Simultaneous Observation of Peptide Backbone Lipid Solvation and α‐Helical Structure by Deep‐UV Resonance Raman Spectroscopy
CM Halsey, J Xiong, OO Oshokoya, JA Johnson, S Shinde, JT Beatty, ...
ChemBioChem 12 (14), 2125-2128, 2011
242011
Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP. 664 and BG505 SOSIP. v4. 1-GT1. 1 gp140 envelope glycoprotein trimers as …
N Whitaker, JM Hickey, K Kaur, J Xiong, N Sawant, A Cupo, WH Lee, ...
Journal of pharmaceutical sciences 108 (7), 2264-2277, 2019
232019
Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants
AYH Teh, L Cavacini, Y Hu, OS Kumru, J Xiong, DT Bolick, SB Joshi, ...
Gut microbes 13 (1), 1859813, 2021
192021
The botanical drug substance crofelemer as a model system for comparative characterization of complex mixture drugs
PA Kleindl, J Xiong, A Hewarathna, O Mozziconacci, MK Nariya, ...
Journal of pharmaceutical sciences 106 (11), 3242-3256, 2017
172017
Developing microwave-assisted ionic liquid microextraction for the detection and tracking of hydrophobic pesticides in complex environmental matrices
J Wang, J Xiong, GA Baker, RD JiJi, SN Baker
RSC advances 3 (38), 17113-17119, 2013
152013
Bilayer surface association of the pHLIP peptide promotes extensive backbone desolvation and helically-constrained structures
MC Brown, RA Yakubu, J Taylor, CM Halsey, J Xiong, RD JiJi, JW Cooley
Biophysical Chemistry 187, 1-6, 2014
142014
Effect of 2 emulsion-based adjuvants on the structure and thermal stability of staphylococcus aureus alpha-toxin
Y Wei, J Xiong, NR Larson, V Iyer, G Sanyal, SB Joshi, DB Volkin, ...
Journal of pharmaceutical sciences 107 (9), 2325-2334, 2018
122018
Role of Bilayer Characteristics on the Structural Fate of Aβ (1–40) and Aβ (25–40)
J Xiong, CA Roach, OO Oshokoya, RP Schroell, RA Yakubu, ...
Biochemistry 53 (18), 3004-3011, 2014
122014
Hydrogen bonds are a primary driving force for de novo protein folding
S Lee, C Wang, H Liu, J Xiong, R Jiji, X Hong, X Yan, Z Chen, M Hammel, ...
Acta Crystallographica Section D: Structural Biology 73 (12), 955-969, 2017
112017
Mechanism of thimerosal-induced structural destabilization of a recombinant rotavirus P [4] protein antigen formulated as a multi-dose vaccine
K Kaur, J Xiong, N Sawant, S Agarwal, JM Hickey, DA Holland, ...
Journal of pharmaceutical sciences 110 (3), 1054-1066, 2021
102021
Insights into the aggregation mechanism of Aβ (25–40)
J Xiong, RD JiJi
Biophysical Chemistry 220, 42-48, 2017
102017
Chemical stability of the botanical drug substance crofelemer: a model system for comparative characterization of complex mixture drugs
A Hewarathna, O Mozziconacci, MK Nariya, PA Kleindl, J Xiong, ...
Journal of pharmaceutical sciences 106 (11), 3257-3269, 2017
92017
Comparative characterization of crofelemer samples using data mining and machine learning approaches with analytical stability data sets
MK Nariya, JH Kim, J Xiong, PA Kleindl, A Hewarathna, AC Fisher, ...
Journal of pharmaceutical sciences 106 (11), 3270-3279, 2017
72017
Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection
L Perruzza, S Jaconi, G Lombardo, D Pinna, F Strati, D Morone, ...
Frontiers in immunology 11, 1011, 2020
62020
Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics
BW Jester, H Zhao, M Gewe, T Adame, L Perruzza, DT Bolick, J Agosti, ...
Nature Biotechnology 40 (6), 974-974, 2022
42022
Hydrogen bonds are a primary driving force for de novo protein folding. Corrigendum
S Lee, C Wang, H Liu, J Xiong, R Jiji, X Hong, X Yan, Z Chen, M Hammel, ...
Acta Crystallographica Section D: Structural Biology 74 (4), 380-380, 2018
12018
Spectroscopic Studies of Proteins and Their Interactions with Lipids and Small Molecules
J Xiong
University of Missouri-Columbia, 2014
12014
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Articles 1–20