Chemical proteomics and phenotypic profiling identifies the aryl hydrocarbon receptor as a molecular target of the utrophin modulator ezutromid IVL Wilkinson, KJ Perkins, H Dugdale, L Moir, A Vuorinen, ... Angewandte Chemie International Edition 59 (6), 2420-2428, 2020 | 39 | 2020 |
Combining experimental strategies for successful target deconvolution IVL Wilkinson, GC Terstappen, AJ Russell Drug Discovery Today 25 (11), 1998-2005, 2020 | 32 | 2020 |
From diagnosis to therapy in Duchenne muscular dystrophy A Babbs, M Chatzopoulou, B Edwards, SE Squire, IVL Wilkinson, ... Biochemical Society Transactions 48 (3), 813-821, 2020 | 27 | 2020 |
Functionalised Cofactor Mimics for Interactome Discovery and Beyond IVL Wilkinson, M Pfanzelt, SA Sieber Angewandte Chemie International Edition 61 (29), e202201136, 2022 | 16 | 2022 |
Discovery and mechanism of action studies of 4, 6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy A Vuorinen, IVL Wilkinson, M Chatzopoulou, B Edwards, SE Squire, ... European Journal of Medicinal Chemistry 220, 113431, 2021 | 13 | 2021 |
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid M Chatzopoulou, TDW Claridge, KE Davies, SG Davies, DJ Elsey, E Emer, ... Journal of Medicinal Chemistry 63 (5), 2547-2556, 2019 | 11 | 2019 |
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase IVL Wilkinson, JK Reynolds, SRG Galan, A Vuorinen, AJ Sills, E Pires, ... Bioorganic Chemistry 94, 103395, 2020 | 8 | 2020 |
Profiling the Heme‐Binding Proteomes of Bacteria Using Chemical Proteomics IVL Wilkinson, M Bottlinger, Y El Harraoui, SA Sieber Angewandte Chemie International Edition 62 (9), e202212111, 2023 | 7 | 2023 |
The cyanobacterial “nutraceutical” phycocyanobilin inhibits cysteine protease legumain IVL Wilkinson, G Castro‐Falcón, MC Roda‐Serrat, TN Purdy, J Straetener, ... ChemBioChem 24 (5), e202200455, 2023 | 3 | 2023 |
Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family CE Quevedo, CJR Bataille, S Byrne, M Durbin, J Elkins, A Guillermo, ... Bioorganic & Medicinal Chemistry 28 (22), 115724, 2020 | 3 | 2020 |
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells TR Jackson, A Vuorinen, L Josa-Culleré, KS Madden, D Conole, ... Iscience 25 (8), 2022 | 2 | 2022 |
A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells TR Jackson, A Vuorinen, L Josa-Culleré, KS Madden, D Conole, ... bioRxiv, 2021.06. 03.446952, 2021 | 2 | 2021 |
International Commission on the Clinical Use of Human Germline Genome Editing K DAVIES, RP LIFTON, H AKUTSU, R CALIFF, D CARROLL, ... The National Academies os Sciences, Engineering Medicine, 2021 | 1 | 2021 |
Soil structure and its benefits - an evidence synthesis. The Royal Society. https://royalsociety.org/-/media/policy/projects/soil-structures/soil …, 2020 | | 2020 |
Target identification studies of a utrophin modulator for treatment of Duchenne muscular dystrophy I Wilkinson, A Vuorinen, J Reynolds, K Perkins, H Dugdale, S Squire, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019 | | 2019 |
Mechanism of action studies of the utrophin modulator ezutromid for the treatment of Duchenne muscular dystrophy I Wilkinson University of Oxford, 2019 | | 2019 |
Small molecule utrophin modulators for the therapy of Duchenne muscular dystrophy (DMD) A Russell, A Vuorinen, N Willis, D Conole, M Chatzopoulou, E Emer, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |