| Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1 W Xu, MR Edwards, DM Borek, AR Feagins, A Mittal, JB Alinger, KN Berry, ... Cell host & microbe 16 (2), 187-200, 2014 | 254 | 2014 |
| Accessory protein recruitment motifs in clathrin-mediated endocytosis TJ Brett, LM Traub, DH Fremont Structure 10 (6), 797-809, 2002 | 246 | 2002 |
| The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ... Science translational medicine 11 (505), eaau2291, 2019 | 220 | 2019 |
| IL-13–induced airway mucus production is attenuated by MAPK13 inhibition YG Alevy, AC Patel, AG Romero, DA Patel, J Tucker, WT Roswit, CA Miller, ... The Journal of clinical investigation 122 (12), 4555-4568, 2012 | 216 | 2012 |
| TREM2-ligand interactions in health and disease DL Kober, TJ Brett Journal of molecular biology 429 (11), 1607-1629, 2017 | 204 | 2017 |
| PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection Y Zhang, D Mao, WT Roswit, X Jin, AC Patel, DA Patel, E Agapov, Z Wang, ... Nature immunology 16 (12), 1215-1227, 2015 | 196 | 2015 |
| TREM-2 promotes macrophage survival and lung disease after respiratory viral infection K Wu, DE Byers, X Jin, E Agapov, J Alexander-Brett, AC Patel, M Cella, ... Journal of Experimental Medicine 212 (5), 681-697, 2015 | 195 | 2015 |
| Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ... elife 5, e20391, 2016 | 190 | 2016 |
| Clathrin-and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins SK Mishra, NR Agostinelli, TJ Brett, I Mizukami, TS Ross, LM Traub Journal of Biological Chemistry 276 (49), 46230-46236, 2001 | 154 | 2001 |
| Structural basis of chemokine sequestration by a herpesvirus decoy receptor JM Alexander, CA Nelson, V Van Berkel, EK Lau, JM Studts, TJ Brett, ... Cell 111 (3), 343-356, 2002 | 144 | 2002 |
| N-domain–dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation N Ota, TJ Brett, TL Murphy, DH Fremont, KM Murphy Nature immunology 5 (2), 208-215, 2004 | 140 | 2004 |
| The role of CLCA proteins in inflammatory airway disease AC Patel, TJ Brett, MJ Holtzman Annual review of physiology 71, 425-449, 2009 | 135 | 2009 |
| Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells M Sala-Rabanal, Z Yurtsever, CG Nichols, TJ Brett elife 4, e05875, 2015 | 115 | 2015 |
| Data publication with the structural biology data grid supports live analysis PA Meyer, S Socias, J Key, E Ransey, EC Tjon, A Buschiazzo, M Lei, ... Nature communications 7 (1), 10882, 2016 | 109 | 2016 |
| Structural definition of the F-actin–binding THATCH domain from HIP1R TJ Brett, V Legendre-Guillemin, PS McPherson, DH Fremont Nature structural & molecular biology 13 (2), 121-130, 2006 | 96 | 2006 |
| Dual engagement regulation of protein interactions with the AP-2 adaptor α appendage SK Mishra, MJ Hawryluk, TJ Brett, PA Keyel, AL Dupin, A Jha, JE Heuser, ... Journal of Biological Chemistry 279 (44), 46191-46203, 2004 | 93 | 2004 |
| Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release M Swiecki, SM Scheaffer, M Allaire, DH Fremont, M Colonna, TJ Brett Journal of Biological Chemistry 286 (4), 2987-2997, 2011 | 91 | 2011 |
| Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated Chloride Channel activation*♦ Z Yurtsever, M Sala-Rabanal, DT Randolph, SM Scheaffer, WT Roswit, ... Journal of Biological Chemistry 287 (50), 42138-42149, 2012 | 88 | 2012 |
| Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo MD Combs, RH Knutsen, TJ Broekelmann, HM Toennies, TJ Brett, ... Journal of Biological Chemistry 288 (40), 28869-28880, 2013 | 72 | 2013 |
| BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor M Swiecki, NS Omattage, TJ Brett Molecular immunology 54 (2), 132-139, 2013 | 72 | 2013 |
