| In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates K Musunuru, AC Chadwick, T Mizoguchi, SP Garcia, JE DeNizio, ... Nature 593 (7859), 429-434, 2021 | 499 | 2021 |
| In vivo base editing of PCSK9 (proprotein convertase subtilisin/kexin type 9) as a therapeutic alternative to genome editing AC Chadwick, X Wang, K Musunuru Arteriosclerosis, thrombosis, and vascular biology 37 (9), 1741-1747, 2017 | 226 | 2017 |
| In utero CRISPR-mediated therapeutic editing of metabolic genes AC Rossidis, JD Stratigis, AC Chadwick, HA Hartman, NJ Ahn, H Li, ... Nature medicine 24 (10), 1513-1518, 2018 | 208 | 2018 |
| Reduced blood lipid levels with in vivo CRISPR-Cas9 base editing of ANGPTL3 AC Chadwick, NH Evitt, W Lv, K Musunuru Circulation 137 (9), 975-977, 2018 | 154 | 2018 |
| CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity AJ Beres, D Haribhai, AC Chadwick, PJ Gonyo, CB Williams, ... The Journal of Immunology 189 (1), 464-474, 2012 | 138 | 2012 |
| In utero gene editing for monogenic lung disease D Alapati, WJ Zacharias, HA Hartman, AC Rossidis, JD Stratigis, NJ Ahn, ... Science translational medicine 11 (488), eaav8375, 2019 | 93 | 2019 |
| Oxidized LDL–bound CD36 recruits an Na+/K+-ATPase–Lyn complex in macrophages that promotes atherosclerosis Y Chen, DJ Kennedy, DP Ramakrishnan, M Yang, W Huang, Z Li, Z Xie, ... Science signaling 8 (393), ra91-ra91, 2015 | 83 | 2015 |
| Functional characterization of newly-discovered mutations in human SR-BI AC Chadwick, D Sahoo Public Library of Science 7 (9), e45660, 2012 | 58 | 2012 |
| Impairment of macrophage cholesterol efflux by cholesterol hydroperoxide trafficking: implications for atherogenesis under oxidative stress W Korytowski, K Wawak, P Pabisz, JC Schmitt, AC Chadwick, D Sahoo, ... Arteriosclerosis, thrombosis, and vascular biology 35 (10), 2104-2113, 2015 | 50 | 2015 |
| Acrolein impairs the cholesterol transport functions of high density lipoproteins AC Chadwick, RL Holme, Y Chen, MJ Thomas, MG Sorci-Thomas, ... PloS one 10 (4), e0123138, 2015 | 42 | 2015 |
| GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy LN Kasiewicz, S Biswas, A Beach, H Ren, C Dutta, AM Mazzola, E Rohde, ... Nature Communications 14 (1), 2776, 2023 | 36 | 2023 |
| Genome editing for the study of cardiovascular diseases AC Chadwick, K Musunuru Current cardiology reports 19, 1-8, 2017 | 34 | 2017 |
| Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells EM Kropp, BJ Oleson, KA Broniowska, S Bhattacharya, AC Chadwick, ... Stem Cells Translational Medicine 4 (5), 483-493, 2015 | 34 | 2015 |
| CRISPR-Cas9 genome editing for treatment of atherogenic dyslipidemia AC Chadwick, K Musunuru Arteriosclerosis, thrombosis, and vascular biology 38 (1), 12-18, 2018 | 30 | 2018 |
| NMR structure of the C-terminal transmembrane domain of the HDL receptor, SR-BI, and a functionally relevant leucine zipper motif AC Chadwick, DR Jensen, PJ Hanson, PT Lange, SC Proudfoot, ... Structure 25 (3), 446-457, 2017 | 26 | 2017 |
| Treatment of dyslipidemia using CRISPR/Cas9 genome editing AC Chadwick, K Musunuru Current atherosclerosis reports 19, 1-6, 2017 | 25 | 2017 |
| Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks AC Chadwick, D Sahoo Current Opinion in Endocrinology, Diabetes and Obesity 20 (2), 124-131, 2013 | 15 | 2013 |
| Expression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis AC Chadwick, DR Jensen, FC Peterson, BF Volkman, D Sahoo Protein expression and purification 107, 35-42, 2015 | 14 | 2015 |
| New Efficient Synthesis of 1, 2, 4-Trisubstituted Furans by a Sequential Passerini/Wittig/Isomerization Reaction Starting from Baylis–Hillman β-Bromo Aldehydes ZL Ren, M Sun, ZR Guan, MW Ding Synlett 29 (01), 106-110, 2018 | 12 | 2018 |
| Lipid nanoparticles incorporating a GalNAc ligand enable in vivo liver ANGPTL3 editing in wild-type and somatic LDLR knockout non-human primates LN Kasiewicz, S Biswas, A Beach, H Ren, C Dutta, AM Mazzola, E Rohde, ... bioRxiv, 2021.11. 08.467731, 2021 | 9 | 2021 |
