Joshua Leonard
Joshua Leonard
Associate Professor of Chemical and Biological Engineering, Northwestern University
Verified email at - Homepage
Cited by
Cited by
TLR3 deficiency in patients with herpes simplex encephalitis
SY Zhang, E Jouanguy, S Ugolini, A Smahi, G Elain, P Romero, D Segal, ...
science 317 (5844), 1522-1527, 2007
Structural basis of toll-like receptor 3 signaling with double-stranded RNA
L Liu, I Botos, Y Wang, JN Leonard, J Shiloach, DM Segal, DR Davies
Science 320 (5874), 379-381, 2008
Therapeutic applications of extracellular vesicles: clinical promise and open questions
B György, ME Hung, XO Breakefield, JN Leonard
Annual review of pharmacology and toxicology 55, 439, 2015
The TLR3 signaling complex forms by cooperative receptor dimerization
JN Leonard, R Ghirlando, J Askins, JK Bell, DH Margulies, DR Davies, ...
Proceedings of the National Academy of Sciences 105 (1), 258-263, 2008
Stabilization of exosome-targeting peptides via engineered glycosylation
ME Hung, JN Leonard
Journal of Biological Chemistry 290 (13), 8166-8172, 2015
FedExosomes: engineering therapeutic biological nanoparticles that truly deliver
ME Marcus, JN Leonard
Pharmaceuticals 6 (5), 659-680, 2013
TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection
I Jelinek, JN Leonard, GE Price, KN Brown, A Meyer-Manlapat, ...
The Journal of Immunology 186 (4), 2422-2429, 2011
Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis
C Ricci, V Pastukh, J Leonard, J Turrens, G Wilson, D Schaffer, ...
American Journal of Physiology-Cell Physiology 294 (2), C413-C422, 2008
Antiviral RNAi therapy: emerging approaches for hitting a moving target
JN Leonard, DV Schaffer
Gene therapy 13 (6), 532-540, 2006
A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery
ME Hung, JN Leonard
Journal of extracellular vesicles 5 (1), 31027, 2016
Lentivirus delivery of IL‐10 to promote and sustain macrophage polarization towards an anti‐inflammatory phenotype
RM Boehler, R Kuo, S Shin, AG Goodman, MA Pilecki, JN Leonard, ...
Biotechnology and bioengineering 111 (6), 1210-1221, 2014
Rewiring human cellular input–output using modular extracellular sensors
KA Schwarz, NM Daringer, TB Dolberg, JN Leonard
Nature chemical biology 13 (2), 202-209, 2017
Modular extracellular sensor architecture for engineering mammalian cell-based devices
NM Daringer, RM Dudek, KA Schwarz, JN Leonard
ACS synthetic biology 3 (12), 892-902, 2014
Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets
JMH Liu, J Zhang, X Zhang, KA Hlavaty, CF Ricci, JN Leonard, LD Shea, ...
Biomaterials 80, 11-19, 2016
Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression
RM Gower, RM Boehler, SM Azarin, CF Ricci, JN Leonard, LD Shea
Biomaterials 35 (6), 2024-2031, 2014
Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape
JN Leonard, DV Schaffer
Journal of Virology 79 (3), 1645-1654, 2005
Staying on message: design principles for controlling nonspecific responses to siRNA
S Samuel‐Abraham, JN Leonard
The FEBS journal 277 (23), 4828-4836, 2010
HIV evades RNA interference directed at TAR by an indirect compensatory mechanism
JN Leonard, PS Shah, JC Burnett, DV Schaffer
Cell host & microbe 4 (5), 484-494, 2008
Engineering modular biosensors to confer metabolite-responsive regulation of transcription
AKD Younger, NC Dalvie, AG Rottinghaus, JN Leonard
ACS synthetic biology 6 (2), 311-325, 2017
Biology by design: from top to bottom and back
BR Fritz, LE Timmerman, NM Daringer, JN Leonard, MC Jewett
Journal of Biomedicine and Biotechnology 2010, 2010
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