| Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity M Bruncko, L Wang, GS Sheppard, DC Phillips, SK Tahir, J Xue, ... Journal of medicinal chemistry 58 (5), 2180-2194, 2015 | 184 | 2015 |
| Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport V Wilson, X Lou, DJ Osterling, DF Stolarik, G Jenkins, W Gao, GGZ Zhang, ... Journal of controlled release 292, 172-182, 2018 | 142 | 2018 |
| The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein· hsp90 complex Y Morishima, KC Kanelakis, PJM Murphy, ER Lowe, GJ Jenkins, Y Osawa, ... Journal of Biological Chemistry 278 (49), 48754-48763, 2003 | 125 | 2003 |
| Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase HM Peng, Y Morishima, GJ Jenkins, AY Dunbar, M Lau, C Patterson, ... Journal of Biological Chemistry 279 (51), 52970-52977, 2004 | 83 | 2004 |
| The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199 EF Choo, J Boggs, C Zhu, JW Lubach, ND Catron, G Jenkins, AJ Souers, ... Drug Metabolism and Disposition 42 (2), 207-212, 2014 | 58 | 2014 |
| Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis AY Dunbar, Y Kamada, GJ Jenkins, ER Lowe, SS Billecke, Y Osawa Molecular pharmacology 66 (4), 964-969, 2004 | 52 | 2004 |
| Clinical efficacy of sustained-release buprenorphine with meloxicam for postoperative analgesia in beagle dogs undergoing ovariohysterectomy EA Nunamaker, DAF Stolarik, J Ma, AS Wilsey, GJ Jenkins, CL Medina Journal of the American Association for Laboratory Animal Science 53 (5 …, 2014 | 50 | 2014 |
| Amorphous solid dispersions of enzalutamide and novel polysaccharide derivatives: Investigation of relationships between polymer structure and performance VR Wilson, X Lou, DJ Osterling, DAF Stolarik, GJ Jenkins, BLB Nichols, ... Scientific reports 10 (1), 18535, 2020 | 44 | 2020 |
| Pharmacokinetics of sustained-release and transdermal buprenorphine in Göttingen minipigs (Sus scrofa domestica) AJ Thiede, KD Garcia, DAF Stolarik, J Ma, GJ Jenkins, EA Nunamaker Journal of the American Association for Laboratory Animal Science 53 (6 …, 2014 | 39 | 2014 |
| Mathematical and experimental validation of flux dialysis method: an improved approach to measure unbound fraction for compounds with high protein binding and other challenging … JC Kalvass, C Phipps, GJ Jenkins, P Stuart, X Zhang, L Heinle, ... Drug Metabolism and Disposition 46 (4), 458-469, 2018 | 37 | 2018 |
| Assessing the impact of endogenously derived crystalline drug on the in vivo performance of amorphous formulations HS Purohit, NS Trasi, DJ Osterling, DF Stolarik, GJ Jenkins, W Gao, ... Molecular pharmaceutics 16 (8), 3617-3625, 2019 | 30 | 2019 |
| Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase Y Kamada, GJ Jenkins, M Lau, AY Dunbar, ER Lowe, Y Osawa Molecular brain research 142 (1), 19-27, 2005 | 22 | 2005 |
| Expanding the repertoire for “large small molecules”: prodrug ABBV-167 efficiently converts to venetoclax with reduced food effect in healthy volunteers AH Salem, ZF Tao, OF Bueno, J Chen, S Chen, R Edalji, SW Elmore, ... Molecular Cancer Therapeutics 20 (6), 999-1008, 2021 | 15 | 2021 |
| Effects of microtubule-inhibiting small molecule and antibody-drug conjugate treatment on differentially-sized A431 squamous carcinoma spheroids KR Durbin, MS Nottoli, GJ Jenkins Scientific Reports 10 (1), 907, 2020 | 15 | 2020 |
| High-throughput, multispecies, parallelized plasma stability assay for the determination and characterization of antibody–drug conjugate aggregation and drug release KR Durbin, MS Nottoli, ND Catron, N Richwine, GJ Jenkins ACS omega 2 (8), 4207-4215, 2017 | 14 | 2017 |
| Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein KM Clapp, HM Peng, GJ Jenkins, MJ Ford, Y Morishima, M Lau, Y Osawa Journal of Biological Chemistry 287 (51), 42601-42610, 2012 | 13 | 2012 |
| Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo AY Dunbar, GJ Jenkins, S Jianmongkol, M Nakatsuka, ER Lowe, M Lau, ... Drug metabolism and disposition 34 (9), 1448-1456, 2006 | 12 | 2006 |
| Determination of IL-23 pharmacokinetics by highly sensitive accelerator mass spectrometry and subsequent modeling to project IL-23 suppression in psoriasis patients treated … TT Zhang, J Ma, KR Durbin, T Montavon, SE Lacy, GJ Jenkins, S Doktor, ... The AAPS Journal 21, 1-11, 2019 | 11 | 2019 |
| Towards in vitro models for reducing or replacing the use of animals in drug testing DM Stresser, AK Kopec, P Hewitt, RN Hardwick, TR Van Vleet, ... Nature Biomedical Engineering, 1-6, 2023 | 9 | 2023 |
| Metabolism of Aminoguanidine, Diaminoguanidine, and NG-Amino-l-arginine by Neuronal NO-Synthase and Covalent Alteration of the Heme Prosthetic Group AJ Lee, KR Noon, S Jianmongkol, M Lau, GJ Jenkins, Y Osawa Chemical research in toxicology 18 (12), 1927-1933, 2005 | 9 | 2005 |
