Roberto Chiesa

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Gianluigi ForloniHead of Neuroscience Department IRCCS Mario Negri, MilanVerified email at marionegri.it
Mario SalmonaCapo del Dipartimento di Biochimica e Farmacologia MolecolareVerified email at marionegri.it
Fabrizio TagliaviniFondazione IRCCS Istituto Neurologico Carlo Besta, MilanoVerified email at istituto-besta.it
Emiliano BiasiniDepartment of Cellular, Computational & Integrative Biology (CIBIO), University of Trento, ITALYVerified email at unitn.it
Marco GobbiIstituto di Ricerche Farmacologiche Mario Negri IRCCSVerified email at marionegri.it
Matteo StravalaciFondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoVerified email at policlinico.mi.it
Valentina BonettoCoordinator of the Research Center for ALS, Head of the Laboratory of Translational BiomarkersVerified email at marionegri.it
Antonio MasoneColumbia University Irving Medical Center - Taub InstituteVerified email at cumc.columbia.edu
Luca ImeriAssociate Professor of Human Physiology, University of Milan Medical School, Milan, ItalyVerified email at unimi.it
Edoardo MicottiDept. of Neuroscience - Mario Negri Institute for Pharmacological ResearchVerified email at marionegri.it
Elisa R ZanierDepartment of Acute Brain and Cardiovascular Injury, Mario Negri Institute IRCCSVerified email at marionegri.it
Antonio MigheliUniversity of TurinVerified email at unito.it
Maria Grazia De SimoniMario NegriVerified email at marionegri.it
Federico Del GalloEvotecVerified email at evotec.com
Francesca PischiuttaIRCCS - Istituto di Ricerche Farmacologiche Mario NegriVerified email at marionegri.it
William StewartQueen Elizabeth University Hospital Glasgow; University of Glasgow; University of PennsylvaniaVerified email at glasgow.ac.uk
Giorgio GiacconeFondazione IRCCS Istituto Neurologica BestaVerified email at istituto-besta.it
Annamaria VezzaniIRCCS-Istituto di Ricerche Farmacologiche Mario NegriVerified email at marionegri.it
Michela MatteoliCNR Istituto di Neuroscienze e IRCCS HumanitasVerified email at in.cnr.it
raffaella moriniLaboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center,Verified email at humanitasresearch.it

Roberto Chiesa

Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan

Verified email at marionegri.it - Homepage

Prions Alzheimer's disease Marinesco-Sjögren syndrome


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Neurotoxicity of a prion protein fragment G Forloni, N Angeretti, R Chiesa, E Monzani, M Salmona, O Bugiani, ... Nature 362 (6420), 543-546, 1993	1166	1993
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein C Balducci, M Beeg, M Stravalaci, A Bastone, A Sclip, E Biasini, L Tapella, ... Proceedings of the National Academy of Sciences 107 (5), 2295-2300, 2010	613	2010
Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35 G Forloni, R Chiesa, S Smiroldo, L Verga, M Salmona, F Tagliavini, ... Neuroreport 4 (5), 523-526, 1993	426	1993
Neurological illness in transgenic mice expressing a prion protein with an insertional mutation R Chiesa, P Piccardo, B Ghetti, DA Harris Neuron 21 (6), 1339-1351, 1998	389	1998
Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation B Drisaldi, RS Stewart, C Adles, LR Stewart, E Quaglio, E Biasini, L Fioriti, ... Journal of Biological Chemistry 278 (24), 21732-21743, 2003	287	2003
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105–125 A Li, HM Christensen, LR Stewart, KA Roth, R Chiesa, DA Harris The EMBO journal 26 (2), 548-558, 2007	261	2007
Evidence for a six-transmembrane domain structure of presenilin 1 S Lehmann, R Chiesa, DA Harris Journal of Biological Chemistry 272 (18), 12047-12051, 1997	223	1997
Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform E Quaglio, R Chiesa, DA Harris Journal of Biological Chemistry 276 (14), 11432, 2001	220	2001
Prion diseases: what is the neurotoxic molecule? R Chiesa, DA Harris Neurobiology of disease 8 (5), 743-763, 2001	211	2001
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation R Chiesa, B Drisaldi, E Quaglio, A Migheli, P Piccardo, B Ghetti, DA Harris Proceedings of the National Academy of Sciences 97 (10), 5574-5579, 2000	190	2000
Molecular distinction between pathogenic and infectious properties of the prion protein R Chiesa, P Piccardo, E Quaglio, B Drisaldi, SL Si-Hoe, M Takao, B Ghetti, ... Journal of virology 77 (13), 7611-7622, 2003	179	2003
Induction of a transmissible tau pathology by traumatic brain injury ER Zanier, I Bertani, E Sammali, F Pischiutta, MA Chiaravalloti, ... Brain 141 (9), 2685-2699, 2018	156	2018
Monoclonal antibodies to human DNA topoisomerase I and the two isoforms of DNA topoisomerase II: 170-and 180-kDa isozymes C Negri, R Chiesa, A Cerino, M Bestagno, C Sala, N Zini, NM Maraldi, ... Experimental cell research 200 (2), 452-459, 1992	150	1992
Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein A Orsi, L Fioriti, R Chiesa, R Sitia Journal of Biological Chemistry 281 (41), 30431-30438, 2006	142	2006
Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations L Fioriti, S Dossena, LR Stewart, RS Stewart, DA Harris, G Forloni, ... Journal of Biological Chemistry 280 (12), 11320-11328, 2005	137	2005
A neurotoxic prion protein fragment induces rat astroglial proliferation and hypertrophy G Forloni, R Del Bo, N Angeretti, R Chiesa, S Smiroldo, R Doni, ... European Journal of Neuroscience 6 (9), 1415-1422, 1994	135	1994
Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model S Dossena, L Imeri, M Mangieri, A Garofoli, L Ferrari, A Senatore, ... Neuron 60 (4), 598-609, 2008	134	2008
Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease R Chiesa, P Piccardo, S Dossena, L Nowoslawski, KA Roth, B Ghetti, ... Proceedings of the National Academy of Sciences 102 (1), 238-243, 2005	114	2005
Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells E Biasini, L Fioriti, I Ceglia, R Invernizzi, A Bertoli, R Chiesa, G Forloni Journal of neurochemistry 88 (3), 545-553, 2004	93	2004
Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease I Bouybayoune, S Mantovani, F Del Gallo, I Bertani, E Restelli, L Comerio, ... PLoS pathogens 11 (4), e1004796, 2015	84	2015

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