Adverse outcome pathways: opportunities, limitations and open questions M Leist, A Ghallab, R Graepel, R Marchan, R Hassan, SH Bennekou, ... Archives of Toxicology 91, 3477-3505, 2017 | 332 | 2017 |
Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood A Ghallab, U Hofmann, S Sezgin, N Vartak, R Hassan, A Zaza, P Godoy, ... Hepatology 69 (2), 666-683, 2019 | 99 | 2019 |
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling KM Schneider, LS Candels, JR Hov, M Myllys, R Hassan, CV Schneider, ... Nature Metabolism 3 (9), 1228-1241, 2021 | 70 | 2021 |
Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage A Schenk, A Ghallab, U Hofmann, R Hassan, M Schwarz, A Schuppert, ... Scientific Reports 7 (1), 6224, 2017 | 65 | 2017 |
Influence of liver fibrosis on lobular zonation A Ghallab, M Myllys, C H. Holland, A Zaza, W Murad, R Hassan, ... Cells 8 (12), 1556, 2019 | 59 | 2019 |
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI S Sezgin, R Hassan, S Zühlke, L Kuepfer, JG Hengstler, M Spiteller, ... Archives of Toxicology 92, 2963-2977, 2018 | 53 | 2018 |
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity A Ghallab, R Hassan, U Hofmann, A Friebel, Z Hobloss, L Brackhagen, ... Journal of Hepatology 77 (1), 71-83, 2022 | 42 | 2022 |
Spatio-temporal multiscale analysis of western diet-fed mice reveals a translationally relevant sequence of events during NAFLD progression A Ghallab, M Myllys, A Friebel, J Duda, K Edlund, E Halilbasic, M Vucur, ... Cells 10 (10), 2516, 2021 | 34 | 2021 |
Transcriptomic cross‐species analysis of chronic liver disease reveals consistent regulation between humans and mice CH Holland, RO Ramirez Flores, M Myllys, R Hassan, K Edlund, ... Hepatology Communications 6 (1), 161-177, 2022 | 31 | 2022 |
Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance J Remetic, A Ghallab, Z Hobloss, L Brackhagen, R Hassan, M Myllys, ... Hepatology 75 (5), 1095-1109, 2022 | 20 | 2022 |
Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney A Ghallab, R Hassan, M Myllys, W Albrecht, A Friebel, S Hoehme, ... Archives of Toxicology 95 (6), 2163-2177, 2021 | 17 | 2021 |
Possibilities and limitations of intravital imaging R Hassan EXCLI journal 15, 872, 2016 | 15 | 2016 |
Inhibition of cytochrome P450 enhances the nephro-and hepatotoxicity of ochratoxin A R Hassan, D González, Z Hobloss, L Brackhagen, M Myllys, A Friebel, ... Archives of Toxicology 96 (12), 3349-3361, 2022 | 14 | 2022 |
Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity R Hassan, A Friebel, L Brackhagen, Z Hobloss, M Myllys, D González, ... Archives of Toxicology 96 (11), 2967-2981, 2022 | 12 | 2022 |
Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis A Ghallab, D González, E Strängberg, U Hofmann, M Myllys, R Hassan, ... Journal of hepatology 80 (2), 268-281, 2024 | 11 | 2024 |
Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury L Wehling, L Keegan, P Fernández-Palanca, R Hassan, A Ghallab, ... Elife 11, e78540, 2022 | 7 | 2022 |
Highlight report: The EDI3-GPAM axis in tumor cell migration R Hassan EXCLI journal 16, 1148, 2017 | 7 | 2017 |
In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin J Dichamp, G Cellière, A Ghallab, R Hassan, N Boissier, U Hofmann, ... Frontiers in Bioengineering and Biotechnology 11, 1049564, 2023 | 5 | 2023 |
Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins R Hassan, M Myllys, L Brackhagen, Z Hobloss, D González, A Seddek, ... Archives of Toxicology 96 (11), 3067-3076, 2022 | 4 | 2022 |
Automated detection of portal fields and central veins in whole-slide images of liver tissue D Budelmann, H Laue, N Weiss, U Dahmen, LA D’Alessandro, ... Journal of Pathology Informatics 13, 100001, 2022 | 3 | 2022 |