| The Genome Sequence of Drosophila melanogaster MD Adams, SE Celniker, RA Holt, CA Evans, JD Gocayne, ... Science 287 (5461), 2185-2195, 2000 | 8190 | 2000 |
| PPARγ signaling and metabolism: the good, the bad and the future M Ahmadian, JM Suh, N Hah, C Liddle, AR Atkins, M Downes, RM Evans Nature medicine 19 (5), 557-566, 2013 | 2050 | 2013 |
| Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells R Lister, M Pelizzola, YS Kida, RD Hawkins, JR Nery, G Hon, ... Nature 471 (7336), 68-73, 2011 | 1805 | 2011 |
| AMPK and PPARδ agonists are exercise mimetics VA Narkar, M Downes, TY Ruth, E Embler, YX Wang, E Banayo, ... Cell 134 (3), 405-415, 2008 | 1473 | 2008 |
| Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network AL Bookout, Y Jeong, M Downes, TY Ruth, RM Evans, DJ Mangelsdorf Cell 126 (4), 789-799, 2006 | 1197 | 2006 |
| Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor T Inagaki, A Moschetta, YK Lee, L Peng, G Zhao, M Downes, RT Yu, ... Proceedings of the National Academy of Sciences 103 (10), 3920-3925, 2006 | 1182 | 2006 |
| Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β H Cho, X Zhao, M Hatori, RT Yu, GD Barish, MT Lam, LW Chong, ... Nature 485 (7396), 123-127, 2012 | 1094 | 2012 |
| Nuclear receptor expression links the circadian clock to metabolism X Yang, M Downes, TY Ruth, AL Bookout, W He, M Straume, ... Cell 126 (4), 801-810, 2006 | 1079 | 2006 |
| Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy MH Sherman, TY Ruth, DD Engle, N Ding, AR Atkins, H Tiriac, ... Cell 159 (1), 80-93, 2014 | 1057 | 2014 |
| Humanized xenobiotic response in mice expressing nuclear receptor SXR W Xie, JL Barwick, M Downes, B Blumberg, CM Simon, MC Nelson, ... Nature 406 (6794), 435-439, 2000 | 834 | 2000 |
| A histone deacetylase corepressor complex regulates the Notch signal transduction pathway HY Kao, P Ordentlich, N Koyano-Nakagawa, Z Tang, M Downes, ... Genes & development 12 (15), 2269-2277, 1998 | 765 | 1998 |
| Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance S Fang, JM Suh, SM Reilly, E Yu, O Osborn, D Lackey, E Yoshihara, ... Nature medicine 21 (2), 159-165, 2015 | 734 | 2015 |
| A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response N Ding, TY Ruth, N Subramaniam, MH Sherman, C Wilson, R Rao, ... Cell 153 (3), 601-613, 2013 | 641 | 2013 |
| Cryptochromes mediate rhythmic repression of the glucocorticoid receptor KA Lamia, SJ Papp, RT Yu, GD Barish, NH Uhlenhaut, JW Jonker, ... Nature 480 (7378), 552-556, 2011 | 617 | 2011 |
| Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis MM Mihaylova, DS Vasquez, K Ravnskjaer, PD Denechaud, TY Ruth, ... Cell 145 (4), 607-621, 2011 | 601 | 2011 |
| Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression HY Kao, M Downes, P Ordentlich, RM Evans Genes & development 14 (1), 55-66, 2000 | 546 | 2000 |
| Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRα and γ CR Dufour, BJ Wilson, JM Huss, DP Kelly, WA Alaynick, M Downes, ... Cell metabolism 5 (5), 345-356, 2007 | 487 | 2007 |
| Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity S Shalapour, XJ Lin, IN Bastian, J Brain, AD Burt, AA Aksenov, ... Nature 551 (7680), 340-345, 2017 | 479 | 2017 |
| An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice SM Reilly, SH Chiang, SJ Decker, L Chang, M Uhm, MJ Larsen, JR Rubin, ... Nature medicine 19 (3), 313-321, 2013 | 441 | 2013 |
| A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR M Downes, MA Verdecia, AJ Roecker, R Hughes, JB Hogenesch, ... Molecular cell 11 (4), 1079-1092, 2003 | 438 | 2003 |
Christopher LiddleProfessor of Clinical Pharmacology and Hepatology, University of SydneyVerified email at sydney.edu.au
