| The first potent and selective inhibitors of the glycine transporter type 2 WL Caulfield, IT Collie, RS Dickins, O Epemolu, R McGuire, DR Hill, ... Journal of medicinal chemistry 44 (17), 2679-2682, 2001 | 124 | 2001 |
| One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening CP Mpamhanga, D Spinks, LB Tulloch, EJ Shanks, DA Robinson, ... Journal of medicinal chemistry 52 (14), 4454-4465, 2009 | 111 | 2009 |
| HTS and hit finding in academia–from chemical genomics to drug discovery JA Frearson, IT Collie Drug discovery today 14 (23-24), 1150-1158, 2009 | 107 | 2009 |
| Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome JA Morrow, IT Collie, DR Dunbar, GB Walker, M Shahid, DR Hill FEBS letters 439 (3), 334-340, 1998 | 91 | 1998 |
| Identification of Inhibitors of the Leishmania cdc2‐Related Protein Kinase CRK3 LAT Cleghorn, A Woodland, IT Collie, LS Torrie, N Norcross, T Luksch, ... ChemMedChem 6 (12), 2214-2224, 2011 | 62 | 2011 |
| Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 D Spinks, HB Ong, CP Mpamhanga, EJ Shanks, DA Robinson, IT Collie, ... ChemMedChem 6 (2), 302-308, 2011 | 52 | 2011 |
| A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors JR Harrison, S Brand, V Smith, DA Robinson, S Thompson, A Smith, ... Journal of Medicinal Chemistry 61 (18), 8374-8389, 2018 | 46 | 2018 |
| Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei LAT Cleghorn, S Albrecht, L Stojanovski, FRJ Simeons, S Norval, R Kime, ... Journal of Medicinal Chemistry 58 (19), 7695-7706, 2015 | 35 | 2015 |
| A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei MD Urbaniak, IT Collie, W Fang, T Aristotelous, S Eskilsson, OG Raimi, ... ACS chemical biology 8 (9), 1981-1987, 2013 | 33 | 2013 |
| Development of Small‐Molecule Trypanosoma brucei N‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode D Spinks, V Smith, S Thompson, DA Robinson, T Luksch, A Smith, ... ChemMedChem 10 (11), 1821-1836, 2015 | 28 | 2015 |
| Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model C De Fusco, M Schimpl, U Borjesson, T Cheung, I Collie, L Evans, ... Journal of Medicinal Chemistry 64 (10), 6814-6826, 2021 | 20 | 2021 |
| Quinol derivatives as potential trypanocidal agents A Capes, S Patterson, S Wyllie, I Hallyburton, IT Collie, AJ McCarroll, ... Bioorganic & medicinal chemistry 20 (4), 1607-1615, 2012 | 19 | 2012 |
| Optimisation of the Anti‐Trypanosoma brucei Activity of the Opioid Agonist U50488 VC Smith, LAT Cleghorn, A Woodland, D Spinks, I Hallyburton, IT Collie, ... ChemMedChem 6 (10), 1832-1840, 2011 | 10 | 2011 |
| High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei P MacGregor, A Ivens, S Shave, I Collie, D Gray, M Auer, KR Matthews Eukaryotic Cell 13 (3), 412-426, 2014 | 9 | 2014 |
| Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase J Read, IT Collie, M Nguyen-McCarty, C Lucaj, J Robinson, L Conway, ... Bioorganic & Medicinal Chemistry Letters 29 (15), 1962-1967, 2019 | 6 | 2019 |
| Development of a series of pyrrolopyridone MAT2A inhibitors SJ Atkinson, SK Bagal, A Argyrou, S Askin, T Cheung, E Chiarparin, ... Journal of Medicinal Chemistry 67 (6), 4541-4559, 2024 | 1 | 2024 |
| Development of a 2, 4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues LAT Cleghorn, RJ Wall, S Albrecht, SA MacGowan, S Norval, ... Journal of medicinal chemistry 66 (13), 8896-8916, 2023 | | 2023 |
| A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity M Kramer, L Torrie, M Booker, D Spinks, RH Barker, S Oza, M Harris, ... American Journal of Tropical Medicine and Hygiene 83 (5 (Suppl.)), 323-323, 2010 | | 2010 |
| Discovery of the first potent and selective inhibitors of the glycine transporter type 2 and their analgesic properties. Z Rankovic, WL Caulfield, IT Collie, RS Dickins, O Epemolu, R McGuire, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 223, A88-A88, 2002 | | 2002 |
| ORG 5222 antagonises the inhibitory effect of quinpirole on adenylyl cyclase activity mediated by the human D2L receptor A Philpott, I Collie, DR Hill, M Shahid British Journal of Pharmacology-Proceedings Supplement 116, 379P, 1995 | | 1995 |
