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Jing Zeng
Jing Zeng
Boston Children's Hospital, Harvard Medical School
Verified email at childrens.harvard.edu
Title
Cited by
Cited by
Year
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
MF Richter, KT Zhao, E Eton, A Lapinaite, GA Newby, BW Thuronyi, ...
Nature biotechnology 38 (7), 883-891, 2020
6412020
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ...
Nature medicine 25 (5), 776-783, 2019
4382019
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
JM Gehrke, O Cervantes, MK Clement, Y Wu, J Zeng, DE Bauer, L Pinello, ...
Nature biotechnology 36 (10), 977-982, 2018
4232018
Therapeutic base editing of human hematopoietic stem cells
J Zeng, Y Wu, C Ren, J Bonanno, AH Shen, D Shea, JM Gehrke, ...
Nature medicine 26 (4), 535-541, 2020
2302020
Genome editing of HBG1 and HBG2 to induce fetal hemoglobin
JY Métais, PA Doerfler, T Mayuranathan, DE Bauer, SC Fowler, MM Hsieh, ...
Blood advances 3 (21), 3379-3392, 2019
1382019
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci
MC Canver, S Lessard, L Pinello, Y Wu, Y Ilboudo, EN Stern, ...
Nature genetics 49 (4), 625-634, 2017
1132017
Editing aberrant splice sites efficiently restores β-globin expression in β-thalassemia
S Xu, K Luk, Q Yao, AH Shen, J Zeng, Y Wu, HY Luo, C Brendel, L Pinello, ...
Blood, The Journal of the American Society of Hematology 133 (21), 2255-2262, 2019
772019
Small-molecule PAPD5 inhibitors restore telomerase activity in patient stem cells
N Nagpal, J Wang, J Zeng, E Lo, DH Moon, K Luk, RO Braun, ...
Cell Stem Cell 26 (6), 896-909. e8, 2020
732020
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity
S Demirci, J Zeng, Y Wu, N Uchida, AH Shen, D Pellin, J Gamer, ...
The Journal of clinical investigation 130 (12), 6677-6687, 2020
562020
ZNF410 represses fetal globin by singular control of CHD4
DS Vinjamur, Q Yao, MA Cole, C McGuckin, C Ren, J Zeng, M Hossain, ...
Nature genetics 53 (5), 719-728, 2021
462021
Human genetic diversity alters off-target outcomes of therapeutic gene editing
S Cancellieri, J Zeng, LY Lin, M Tognon, MA Nguyen, J Lin, N Bombieri, ...
Nature genetics 55 (1), 34-43, 2023
432023
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing
S Rao, Y Yao, JS de Brito, Q Yao, AH Shen, RE Watkinson, AL Kennedy, ...
Cell Stem Cell 28 (5), 833-845. e5, 2021
282021
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia
G Casirati, A Cosentino, A Mucci, M Salah Mahmoud, I Ugarte Zabala, ...
Nature 621 (7978), 404-414, 2023
202023
Optimization of nuclear localization signal composition improves CRISPR-cas12a editing rates in human primary cells
K Luk, P Liu, J Zeng, Y Wang, SA Maitland, F Idrizi, K Ponnienselvan, ...
GEN biotechnology 1 (3), 271-284, 2022
82022
Durable and robust fetal globin induction without Anemia in rhesus monkeys following autologous hematopoietic stem cell transplant with BCL11A Erythroid enhancer editing
S Demirci, J Zeng, Y Wu, N Uchida, J Gamer, M Yapundich, C Drysdale, ...
Blood 134, 4632, 2019
52019
Gene editing ELANE in human hematopoietic stem and progenitor cells reveals disease mechanisms and therapeutic strategies for severe congenital neutropenia
S Rao, J Brito-Frazao, AV Serbin, Q Yao, K Luk, Y Wu, J Zeng, C Ren, ...
Blood 134, 3, 2019
42019
Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
K Essawi, W Hakami, MBN Khan, R Martin, J Zeng, R Chu, N Uchida, ...
Molecular Therapy-Methods & Clinical Development 29, 483-493, 2023
32023
Combined+ 58 and+ 55 BCL11A enhancer editing Yields exceptional efficiency, specificity and HbF induction in human and NHP preclinical models
J Zeng, S Demirci, MA Nguyen, LY Lin, SA Maitland, E Mintzer, Y Wu, ...
Blood 138, 1852, 2021
22021
Human genetic diversity modifies therapeutic gene editing off-target potential
S Cancellieri, J Zeng, LY Lin, F Masillo, A Nguyen, N Bombieri, ...
bioRxiv, 2021
22021
Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ss-Hemoglobinopathy Patients for Fetal Hemoglobin Induction
J Zeng, DE Bauer, Y Wu, BP Roscoe, P Liu, Q Yao, C Lazzarrotto, ...
Blood 132, 3482, 2018
22018
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