| Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes D Milardi, E Gazit, SE Radford, Y Xu, RU Gallardo, A Caflisch, ... Chemical Reviews 121 (3), 1845-1893, 2021 | 145 | 2021 |
| Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly R Gallardo, MG Iadanza, Y Xu, GR Heath, R Foster, SE Radford, ... Nature Structural & Molecular Biology 27 (11), 1048-1056, 2020 | 74 | 2020 |
| Structural Optimization and Structure–Activity Relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine Derivatives, a New … J Yang, LJ Wang, JJ Liu, L Zhong, RL Zheng, Y Xu, P Ji, CH Zhang, ... Journal of Medicinal Chemistry 55 (23), 10685-10699, 2012 | 66 | 2012 |
| Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-{5-[7-(3- Morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and Its Anti-Acute Myeloid Leukemia … WW Li, XY Wang, RL Zheng, HX Yan, ZX Cao, L Zhong, ZR Wang, P Ji, ... Journal of Medicinal Chemistry 55 (8), 3852-3866, 2012 | 40 | 2012 |
| SKLB1206, a novel orally available multikinase inhibitor targeting EGFR activating and T790M mutants, ErbB2, ErbB4, and VEGFR2, displays potent antitumor activity both in vitro … Y Pan, Y Xu, S Feng, S Luo, R Zheng, J Yang, L Wang, L Zhong, HY Yang, ... Molecular cancer therapeutics 11 (4), 952-962, 2012 | 33 | 2012 |
| Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly Y Xu, R Maya-Martinez, N Guthertz, GR Heath, IW Manfield, AL Breeze, ... Nature Communications 13 (1), 1040, 2022 | 28 | 2022 |
| Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein SM Ulamec, R Maya-Martinez, EJ Byrd, KM Dewison, Y Xu, LF Willis, ... Nature communications 13 (1), 4986, 2022 | 23 | 2022 |
| Covalent inhibitors of LgtC: A blueprint for the discovery of non-substrate-like inhibitors for bacterial glycosyltransferases Y Xu, R Smith, M Vivoli, M Ema, N Goos, S Gehrke, NJ Harmer, ... Bioorganic & Medicinal Chemistry 25 (12), 3182-3194, 2017 | 22 | 2017 |
| Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC Y Xu, J Cuccui, C Denman, T Maharjan, BW Wren, GK Wagner Bioorganic & medicinal chemistry 26 (11), 2973-2983, 2018 | 17 | 2018 |
| Covalent probes for carbohydrate-active enzymes: from glycosidases to glycosyltransferases Y Xu, N Uddin, GK Wagner Methods in Enzymology 598, 237-265, 2018 | 14 | 2018 |
| SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML … ZX Cao, JJ Liu, RL Zheng, J Yang, L Zhong, Y Xu, LJ Wang, CH Zhang, ... Leukemia 26 (8), 1892-1895, 2012 | 14 | 2012 |
| Brazilin removes toxic alpha-Synuclein and seeding competent assemblies from Parkinson brain by altering conformational equilibrium GR Nahass, Y Sun, Y Xu, M Batchelor, M Reilly, I Benilova, N Kedia, ... Journal of molecular biology 433 (8), 166878, 2021 | 11 | 2021 |
| The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain C Leistner, M Wilkinson, A Burgess, M Lovatt, S Goodbody, Y Xu, ... Nature Communications 14 (1), 2833, 2023 | 9 | 2023 |
| The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis N Guthertz, R Van Der Kant, RM Martinez, Y Xu, CH Trinh, BI Iorga, ... Proceedings of the National Academy of Sciences 119 (22), e2200468119, 2022 | 9 | 2022 |
| Identification of non-substrate-like glycosyltransferase inhibitors from library screening: pitfalls & hits M Ema, Y Xu, S Gehrke, GK Wagner MedChemComm 9 (1), 131-137, 2018 | 7 | 2018 |
| Structural modification of an EGFR inhibitor that showed weak off-target activity against RET leading to the discovery of a potent RET inhibitor QZ Sun, Y Xu, JJ Liu, CH Zhang, ZR Wang, RL Zheng, WJ Wang, LL Li, ... Molecular diversity 18, 403-409, 2014 | 7 | 2014 |
| Structural evolution of fibril polymorphs during amyloid assembly M Wilkinson, Y Xu, D Thacker, AIP Taylor, DG Fisher, RU Gallardo, ... Cell 186 (26), 5798-5811. e26, 2023 | 6 | 2023 |
| The in-tissue molecular architecture of β-amyloid in the mammalian brain C Leistner, M Wilkinson, A Burgess, S Goodbody, Y Xu, S Deuchars, ... bioRxiv, 2022.11. 08.515609, 2022 | 4 | 2022 |
| Methyl 6-chloronicotinate Y Xu, LL Yang, SY Yang, J Liu Acta Crystallographica Section E: Structure Reports Online 68 (1), o162-o162, 2012 | 4 | 2012 |
| Controlling amyloid formation of intrinsically disordered proteins and peptides: slowing down or speeding up? Y Xu, R Maya-Martinez, SE Radford Essays in Biochemistry 66 (7), 959-975, 2022 | 3 | 2022 |
