Ross A. Cardarelli

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Stephen MossTufts universityVerified email at tufts.edu
Jamie MaguireTufts University School of MedicineVerified email at tufts.edu
Matt KelleyPfizerVerified email at pfizer.com
Robert MatherPfizer, Inc.Verified email at pfizer.com
Yvonne E MooreMIT and Broad InstituteVerified email at mit.edu
Joshua L SmalleyResearch Assistant Professor, TuftsVerified email at tufts.edu
Paul A. DaviesResearch Associate Professor, Tufts Medical SchoolVerified email at tufts.edu
Roland BurliCerevanceVerified email at cerevance.com
Sudhir SivakumaranBeacon BiosignalsVerified email at beacon.bio
Deepak P. SrivastavaInstitute of Psychiatry, King's College LondonVerified email at kcl.ac.uk
Shiva K TyagarajanUniversity of ZurichVerified email at pharma.uzh.ch
Triller AntoineEcole Normale Supérieure - InsermVerified email at biologie.ens.fr
Yasmine Cantaut-BelarifParis Brain InstituteVerified email at icm-institute.org
Shu Fun Josephine Ng, Ph.D.Scientist II, Tufts UniversityVerified email at tufts.edu
Stefan GeschwindnerDirector Biophysics, Mechanistic & Structural Biology, AstraZeneca R&D GothenburgVerified email at astrazeneca.com
Anders GunnarssonAstraZenecaVerified email at astrazeneca.com
Audebert StephaneCancer Research Center of Marseille (CRCM) Inserm U1068 - CNRS 7258 - AMU 105 - Paoli Calmettes InstVerified email at inserm.fr
Heike Julia WobstJnana TherapeuticsVerified email at jnanatx.com
Georgina KontouVerified email at tufts.edu
Jack H HowdenMSDVerified email at msd.com

Ross A. Cardarelli

Caraway Therapeutics

Verified email at carawaytx.com

Ion channel biology neurodegenerative disorders


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Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo S Sivakumaran, RA Cardarelli, J Maguire, MR Kelley, L Silayeva, ... Journal of Neuroscience 35 (21), 8291-8296, 2015	105	2015
Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses J Mukherjee, RA Cardarelli, Y Cantaut-Belarif, TZ Deeb, DP Srivastava, ... Proceedings of the National Academy of Sciences 114 (44), 11763-11768, 2017	69	2017
Molecular architecture of potassium chloride co-transporter KCC2 M Agez, P Schultz, I Medina, DJ Baker, MP Burnham, RA Cardarelli, ... Scientific reports 7 (1), 16452, 2017	58	2017
Locally reducing KCC2 activity in the hippocampus is sufficient to induce temporal lobe epilepsy MR Kelley, RA Cardarelli, JL Smalley, TA Ollerhead, PM Andrew, ... EBioMedicine 32, 62-71, 2018	53	2018
The small molecule CLP257 does not modify activity of the K⁺–Cl⁻ co-transporter KCC2 but does potentiate GABA_A receptor activity RA Cardarelli, K Jones, LI Pisella, HJ Wobst, LJ McWilliams, PM Sharpe, ... Nature Medicine 23 (12), 1394-1396, 2017	50	2017
N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation LC Conway, RA Cardarelli, YE Moore, K Jones, LJ McWilliams, DJ Baker, ... Journal of Biological Chemistry 292 (52), 21253-21263, 2017	40	2017
KCC2 is required for the survival of mature neurons but not for their development G Kontou, SFJ Ng, RA Cardarelli, JH Howden, C Choi, Q Ren, ... Journal of Biological Chemistry 296, 2021	17	2021
Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy S Kano, M Yuan, RA Cardarelli, G Maegawa, N Higurashi, M Gaval-Cruz, ... Current molecular medicine 15 (2), 138-145, 2015	17	2015
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice R Jarvis, SFJ Ng, AJ Nathanson, RA Cardarelli, K Abiraman, F Wade, ... Cell Reports Medicine 4 (3), 2023	11	2023
Dominant-negative DISC1 alters the dopaminergic modulation of inhibitory interneurons in the mouse prefrontal cortex RA Cardarelli, R Martin, H Jaaro-Peled, A Sawa, EM Powell, P O’Donnell Molecular Neuropsychiatry 4 (1), 20-29, 2018	6	2018
The Putative KCC2 Activating Small Molecule CLP257 Does not Have any Target Engagement or Functional Activity at KCC2 but Does Potentiates GABAA Receptor Activity R Cardarelli, K Jones, L Pisella, L McWilliams, D Baker, M Burnham, ... NEUROPSYCHOPHARMACOLOGY 41, S555-S555, 2016		2016

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