| Discovery of an orally bioavailable and central nervous system (CNS) penetrant mGlu7 negative allosteric modulator (NAM) in vivo tool compound: N-(2-(1 H-1, 2, 4-triazol-1-yl … CW Reed, SE Yohn, JP Washecheck, HF Roenfanz, MC Quitalig, ... Journal of medicinal chemistry 62 (3), 1690-1695, 2019 | 26 | 2019 |
| VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides CW Reed, KM McGowan, PK Spearing, BJ Stansley, HF Roenfanz, ... ACS Medicinal Chemistry Letters 8 (12), 1326-1330, 2017 | 21 | 2017 |
| Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278 CW Reed, JP Washecheck, MC Quitlag, MT Jenkins, AL Rodriguez, ... Bioorganic & medicinal chemistry letters 29 (10), 1211-1214, 2019 | 18 | 2019 |
| Use of chemical probes to explore the toxicological potential of the K+/Cl− cotransporter (KCC) as a novel insecticide target to control the primary vector of dengue and Zika … FJ Prael III, R Chen, Z Li, CW Reed, CW Lindsley, CD Weaver, DR Swale Pesticide biochemistry and physiology 151, 10-17, 2018 | 13 | 2018 |
| Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu7 Positive Allosteric Modulator Tool Compound CW Reed, JJ Kalbfleisch, MJ Wong, JP Washecheck, A Hunter, ... ACS Medicinal Chemistry Letters 11 (9), 1773-1779, 2020 | 10 | 2020 |
| Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses X Lin, NM Fisher, S Dogra, RK Senter, CW Reed, JJ Kalbfleisch, ... Journal of Biological Chemistry 298 (10), 2022 | 8 | 2022 |
| Total synthesis of natural (−)-and unnatural (+)-Melearoride A CW Reed, MG Fulton, KD Nance, CW Lindsley Tetrahedron letters 60 (10), 743-745, 2019 | 7 | 2019 |
| Synthesis and SAR of a series of mGlu7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl) quinoline carboxylate core JJ Kalbfleisch, CW Reed, C Park, PK Spearing, MC Quitalig, MT Jenkins, ... Bioorganic & medicinal chemistry letters 30 (22), 127529, 2020 | 5 | 2020 |
| A general, enantioselective synthesis of 2-substituted thiomorpholines and thiomorpholine 1, 1-dioxides CW Reed, CW Lindsley Tetrahedron letters 60 (40), 151104, 2019 | 3 | 2019 |
| Formal Total Synthesis of Pericoannosin A MG Fulton, JL Bertron, CW Reed, CW Lindsley The Journal of Organic Chemistry 84 (18), 12187-12191, 2019 | 3 | 2019 |
| Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro CW Reed, AL Rodriguez, JJ Kalbfleisch, M Seto, MT Jenkins, AL Blobaum, ... Bioorganic & medicinal chemistry letters 74, 128923, 2022 | 2 | 2022 |
| VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate (vol 29, pg 1714, 2019) CW Reed BIOORGANIC & MEDICINAL CHEMISTRY 28 (24), 2020 | | 2020 |
| Discovery and Development of Novel, Selective Metabotropic Glutamate Receptor 7 Negative and Positive Allosteric Modulators; A General, Enantioselective Synthesis of 2 … CW Reed Vanderbilt University, 2020 | | 2020 |
| Development and Profiling of mGlu 7 NAMs with a Range of in vitro Efficacies CW Reed, AL Rodriguez, JJ Kalbfleisch, M Seto, MT Jenkins, AL Blobaum, ... Efficacies, 0 | | |
