| Heart disease and stroke statistics—2017 update: a report from the American Heart Association EJ Benjamin, MJ Blaha, SE Chiuve, M Cushman, SR Das, R Deo, ... circulation 135 (10), e146-e603, 2017 | 25100 | 2017 |
| Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease FE Dewey, V Gusarova, RL Dunbar, C O’Dushlaine, C Schurmann, ... New England Journal of Medicine 377 (3), 211-221, 2017 | 759 | 2017 |
| Mapping the human genetic architecture of COVID-19 Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ... Nature 600 (7889), 472-477, 2021 | 717 | 2021 |
| Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study FE Dewey, MF Murray, JD Overton, L Habegger, JB Leader, SN Fetterolf, ... Science 354 (6319), aaf6814, 2016 | 549 | 2016 |
| Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease FE Dewey, V Gusarova, C O’Dushlaine, O Gottesman, J Trejos, C Hunt, ... New England Journal of Medicine 374 (12), 1123-1133, 2016 | 496 | 2016 |
| Genetic identification of familial hypercholesterolemia within a single US health care system NS Abul-Husn, K Manickam, LK Jones, EA Wright, DN Hartzel, ... Science 354 (6319), aaf7000, 2016 | 420 | 2016 |
| Exome sequencing and characterization of 49,960 individuals in the UK Biobank CV Van Hout, I Tachmazidou, JD Backman, JD Hoffman, D Liu, ... Nature 586 (7831), 749-756, 2020 | 391 | 2020 |
| Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls J Flannick, JM Mercader, C Fuchsberger, MS Udler, A Mahajan, J Wessel, ... Nature 570 (7759), 71-76, 2019 | 283 | 2019 |
| Whole-genome sequencing reveals host factors underlying critical COVID-19 A Kousathanas, E Pairo-Castineira, K Rawlik, A Stuckey, CA Odhams, ... Nature 607 (7917), 97-103, 2022 | 222 | 2022 |
| Prediction of mortality from 12-lead electrocardiogram voltage data using a deep neural network S Raghunath, AE Ulloa Cerna, L Jing, DP VanMaanen, J Stough, ... Nature medicine 26 (6), 886-891, 2020 | 212 | 2020 |
| Routinely reported ejection fraction and mortality in clinical practice: where does the nadir of risk lie? GJ Wehner, L Jing, CM Haggerty, JD Suever, JB Leader, DN Hartzel, ... European heart journal 41 (12), 1249-1257, 2020 | 211 | 2020 |
| Exome sequencing–based screening for BRCA1/2 expected pathogenic variants among adult biobank participants K Manickam, AH Buchanan, MLB Schwartz, MLG Hallquist, JL Williams, ... JAMA Network Open 1 (5), e182140-e182140, 2018 | 197 | 2018 |
| Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease AV Khera, HH Won, GM Peloso, C O’Dushlaine, D Liu, NO Stitziel, ... Jama 317 (9), 937-946, 2017 | 176 | 2017 |
| Deep neural networks can predict new-onset atrial fibrillation from the 12-lead ECG and help identify those at risk of atrial fibrillation–related stroke S Raghunath, JM Pfeifer, AE Ulloa-Cerna, A Nemani, T Carbonati, L Jing, ... Circulation 143 (13), 1287-1298, 2021 | 148 | 2021 |
| Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes V Gusarova, C O’Dushlaine, TM Teslovich, PN Benotti, T Mirshahi, ... Nature communications 9 (1), 2252, 2018 | 126 | 2018 |
| Genomics-first evaluation of heart disease associated with titin-truncating variants CM Haggerty, SM Damrauer, MG Levin, D Birtwell, DJ Carey, AM Golden, ... Circulation 140 (1), 42-54, 2019 | 119 | 2019 |
| Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank CV Van Hout, I Tachmazidou, JD Backman, JX Hoffman, B Ye, AK Pandey, ... BioRxiv, 572347, 2019 | 110 | 2019 |
| Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease JE Horowitz, JA Kosmicki, A Damask, D Sharma, GHL Roberts, AE Justice, ... Nature genetics 54 (4), 382-392, 2022 | 106 | 2022 |
| Patient-centered precision health in a learning health care system: Geisinger’s genomic medicine experience MS Williams, AH Buchanan, FD Davis, WA Faucett, MLG Hallquist, ... Health Affairs 37 (5), 757-764, 2018 | 95 | 2018 |
| Protein-truncating variants at the cholesteryl ester transfer protein gene and risk for coronary heart disease A Nomura, HH Won, AV Khera, F Takeuchi, K Ito, S McCarthy, CA Emdin, ... Circulation research 121 (1), 81-88, 2017 | 89 | 2017 |
