| Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion WS Ratnayake, CA Apostolatos, S Breedy, CL Dennison, R Hill, ... Cell Adhesion & Migration 15 (1), 37-57, 2021 | 20 | 2021 |
| FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation WS Ratnayke, CA Apostolatos, S Breedy, AH Apostolatos, ... World Academy of Sciences Journal 1 (1), 25-38, 2019 | 9 | 2019 |
| c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 WS Ratnayake, CA Apostolatos, S Breedy, M Acevedo-Duncan World Academy of Sciences Journal 2 (5), 1-1, 2020 | 2 | 2020 |
| Vimentin is a novel PKC-ι target facilitating migration and invasion in melanoma WS Ratnayake, S Breedy, C Apostolatos, R Hill, C Dennison, ... Cancer Research 79 (13_Supplement), 2857-2857, 2019 | 2 | 2019 |
| 14-3-3 and Smad2/3 are crucial mediators of atypical-PKCs: Implications for neuroblastoma progression S Breedy, WS Ratnayake, L Lajmi, R Hill, M Acevedo-Duncan Frontiers in Oncology 13, 1051516, 2023 | 1 | 2023 |
| PKC-ι and PKC-ζ are heavily responsible of up-regulating epithelial-mesenchymal transition (EMT) and activating Vimentin to facilitate cellular motility in prostate cancer cell … WS Ratnayake, C Apostolatos, S Breedy, R Hill, C Dennison, ... Cancer Research 79 (13_Supplement), 1044-1044, 2019 | 1 | 2019 |
| Preclinical Testing of Chronic ICA-1S Exposure: A Potent Protein Kinase C-ι Inhibitor as a Potential Carcinoma Therapeutic CA Apostolatos, WS Ratnayake, S Breedy, JKC Chuah, JA Miller, D Zink, ... Drugs and Drug Candidates 3 (2), 368-379, 2024 | | 2024 |
| Osteoblasts alter their protein expression profile in the presence of prostate cancer cells to facilitate their invasion AJ Todman, WS Ratnayake, L Lajmi, S Breedy, AH Shourav, K Bisht, ... Cancer Research 84 (6_Supplement), 2032-2032, 2024 | | 2024 |
| PKC-ι and 14-3-3 are crucial regulators of c-Raf and the Erk pathway in human medulloblastoma L Lajmi, WS Ratnayake, J Palathinkal, S Breedy, A Todman, ... Cancer Research 84 (6_Supplement), 1672-1672, 2024 | | 2024 |
| PKC-ι/ζ signaling is crucial for apoptosis/pyroptosis inhibition and invasiveness of glioblastoma cells through upregulation of β-catenin, PDK1/Akt1 and Smad cascades via 14-3-3 L Lajmi, WS Ratnayake, KM Khalid, S Breedy, A Todman, T Smalley, ... Cancer Research 84 (6_Supplement), 4382-4382, 2024 | | 2024 |
| Interaction of interleukin-6/8/18 with prostate cancer cell secreted growth factors are crucial for osteoblast proliferation and differentiation AJ Todman, WS Ratnayake, L Lajmi, S Breedy, K Bisht, ... Cancer Research 83 (7_Supplement), 3609-3609, 2023 | | 2023 |
| PKC-ι is a simultaneous modulator of the sonic hedgehog and the FAK/paxillin pathways in medulloblastoma L Lajmi, S Breedy, A Todman, WS Ratnayake, M Acevedo-Duncan Cancer Research 83 (7_Supplement), 344-344, 2023 | | 2023 |
| 14-3-3 and Smad2/3 are key mediators of atypical-PKCs in neuroblastoma progression S Breedy, WS Ratnayake, L Lajmi, R Hill, M Acevedo-Duncan Cancer Research 83 (7_Supplement), 2555-2555, 2023 | | 2023 |
| aPKCs role in Neuroblastoma cell signaling cascades and Implications of aPKCs inhibitors as potential therapeutics S Breedy University of South Florida, 2023 | | 2023 |
| Prevalent PKC-ι/ζ signaling is crucial for apoptosis inhibition and invasiveness of glioblastoma through upregulation of Pdk1/Akt1/14-3-3 cascade and Smad2/3 WS Ratnayake, KM Khalid, S Breedy, L Lajmi, T Smalley, CA Apostolatos, ... Cancer Research 82 (12_Supplement), 150-150, 2022 | | 2022 |
| Limiting medulloblastoma progression by hindering the Hedgehog signaling pathway with novel atypical protein kinase C inhibitors L Lajmi, S Breedy, WS Ratnayake, M Acevedo-Duncan Cancer Research 82 (12_Supplement), 172-172, 2022 | | 2022 |
| A combination therapy of atypical protein kinase C inhibitors and phosphatidylinositol-3-kinase inhibitor reduces resistance & invasiveness in renal cell carcinoma (RCC) KM Khalid, WS Ratnayake, CA Apostolatos, L Lajmi, S Breedy, ... Cancer Research 82 (12_Supplement), 158-158, 2022 | | 2022 |
| Oncogenic PKC-ι/PKC-ζ/14-3-3 and PKC-ι/PKC-ζ/Smad2/3 signaling cascades are crucial for increased invasiveness of Neuroblastoma cells S Breedy Cancer Research 82 (12_Supplement), 164-164, 2022 | | 2022 |
| Atypical PKC inhibitors ICA-1S and ζ-Stat show inhibition of neuroblastoma cell proliferation S Breedy, WS Ratnayake, C Apostolatos, A Dey, M Acevedo-Duncan Cancer Research 80 (16_Supplement), 5216-5216, 2020 | | 2020 |
| ICAM-1 and IL-17E upregulate FOXO1 to suppress the expression of oncogenic PKC-ι in human melanoma WS Ratnayake, C Apostolatos, S Breedy, A Apostolatos, ... Cancer Research 79 (13_Supplement), 5204-5204, 2019 | | 2019 |
