Asymmetric and diastereoselective conjugate addition reactions: C–C bond formation at large scale GP Howell Organic Process Research & Development 16 (7), 1258-1272, 2012 | 135 | 2012 |
Catalytic asymmetric synthesis of acyclic arrays by tandem 1, 4-addition-aldol reactions GP Howell, SP Fletcher, K Geurts, B ter Horst, BL Feringa Journal of the American Chemical Society 128 (46), 14977-14985, 2006 | 125 | 2006 |
An asymmetric nitro-Mannich reaction applicable to alkyl, aryl, and heterocyclic imines JC Anderson, GP Howell, RM Lawrence, CS Wilson The Journal of Organic Chemistry 70 (14), 5665-5670, 2005 | 114 | 2005 |
Asymmetric allylation of aryl aldehydes: studies on the scope and mechanism of the palladium catalysed diethylzinc mediated umpolung using phosphoramidite ligands GP Howell, AJ Minnaard, BL Feringa Organic & Biomolecular Chemistry 4 (7), 1278-1283, 2006 | 90 | 2006 |
Scope and limitations of the nitro-mannich reaction for the stereoselective synthesis of 1, 2-diamines JC Anderson, AJ Blake, GP Howell, C Wilson The Journal of Organic Chemistry 70 (2), 549-555, 2005 | 73 | 2005 |
Changes in superior mesenteric artery blood flow after oral, enteral, and parenteral feeding in humans M Gatt, J MacFie, ADG Anderson, G Howell, BS Reddy, A Suppiah, ... Critical care medicine 37 (1), 171-176, 2009 | 71 | 2009 |
Copper-catalyzed borylative multicomponent synthesis of quaternary α-amino esters K Yeung, FJT Talbot, GP Howell, AP Pulis, DJ Procter ACS Catalysis 9 (3), 1655-1661, 2019 | 49 | 2019 |
Copper‐Catalyzed Borylative Couplings with C− N Electrophiles FJT Talbot, Q Dherbassy, S Manna, C Shi, S Zhang, GP Howell, ... Angewandte Chemie 132 (46), 20454-20465, 2020 | 40 | 2020 |
Modular synthesis of constrained ethyl (cEt) purine and pyrimidine nucleosides H Blade, D Bradley, L Diorazio, T Evans, BR Hayter, GP Howell The Journal of Organic Chemistry 80 (10), 5337-5343, 2015 | 33 | 2015 |
Process design and optimization in the pharmaceutical industry: A Suzuki–Miyaura procedure for the synthesis of savolitinib NK Adlington, LR Agnew, AD Campbell, RJ Cox, A Dobson, CF Barrat, ... The Journal of organic chemistry 84 (8), 4735-4747, 2018 | 24 | 2018 |
Development of scalable manufacturing routes to AZD1981. Application of the Semmler–Wolff aromatisation for synthesis of the indole-4-amide core M Sulur, P Sharma, R Ramakrishnan, R Naidu, E Merifield, DM Gill, ... Organic process research & development 16 (11), 1746-1753, 2012 | 21 | 2012 |
Insights into the cobalt-catalyzed three-component coupling of mixed aromatic organozinc species, carbonyl compounds or imines and Michael acceptors: Synthetic and mechanistic … J Paul, M Presset, E Le Gall, E Leonel, P Retailleau Synthesis 50 (02), 254-266, 2018 | 14 | 2018 |
Regio-selective synthesis of 1, 2-aminoalcohols from epoxides and chlorohydrins A Murugan, VK Kadambar, S Bachu, MR Reddy, V Torlikonda, ... Tetrahedron Letters 53 (43), 5739-5741, 2012 | 13 | 2012 |
Modular synthesis of stereodefined benzocyclobutene derivatives via sequential Cu-and Pd-catalysis FJT Talbot, S Zhang, B Satpathi, GP Howell, GJP Perry, GEM Crisenza, ... ACS Catalysis 11 (23), 14448-14455, 2021 | 11 | 2021 |
Lewis acid promoted trapping of chiral aza-enolates F Lanza, JM Pérez, RP Jumde, SR Harutyunyan Synthesis 51 (05), 1253-1262, 2019 | 11 | 2019 |
Green chemistry articles of interest to the pharmaceutical industry MC Bryan, C Dalton, A Diaz-Rodriguez, J Doerfler, OD Engl, P Ferguson, ... Organic Process Research & Development 26 (2), 251-262, 2022 | 10 | 2022 |
Real-time monitoring and control of critical process impurities during the manufacture of Fostamatinib disodium R Hart, A Herring, GP Howell, B McKeever-Abbas, N Pedge, R Woodward Organic Process Research & Development 19 (4), 537-542, 2015 | 10 | 2015 |
A furan Diels–Alder cycloaddition approach to scyphostatin analogues CJ Fraser, GP Howell, JPA Harrity Organic & Biomolecular Chemistry 10 (45), 9058-9066, 2012 | 9 | 2012 |
Synthesis of 3-Oxoisoindoline-1-carboxamides through Sequential Four-Component Ugi Reaction/Oxidative Nucleophilic Substitution of Hydrogen K Amiri, S Balalaie, MU Anwar, A Al-Harrasi Synlett 31 (09), 861-865, 2020 | 4 | 2020 |
Cumulative complexity meta-metrics as an efficiency measure and predictor of process mass intensity (PMI) during synthetic route design L Angelini, CE Coomber, GP Howell, G Karageorgis, BA Taylor Green Chemistry 25 (14), 5543-5556, 2023 | 3 | 2023 |