Paul Titchenell
Paul Titchenell
Assistant Professor, University of Pennsylvania
Verified email at
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Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
RJ Perry, JPG Camporez, R Kursawe, PM Titchenell, D Zhang, CJ Perry, ...
Cell 160 (4), 745-758, 2015
Unraveling the regulation of hepatic metabolism by insulin
PM Titchenell, MA Lazar, MJ Birnbaum
Trends in Endocrinology & Metabolism 28 (7), 497-505, 2017
Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production
PM Titchenell, WJ Quinn, M Lu, Q Chu, W Lu, C Li, H Chen, BR Monks, ...
Cell metabolism 23 (6), 1154-1166, 2016
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
S Zhao, C Jang, J Liu, K Uehara, M Gilbert, L Izzo, X Zeng, S Trefely, ...
Nature 579 (7800), 586-591, 2020
Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
PM Titchenell, Q Chu, BR Monks, MJ Birnbaum
Nature communications 6 (1), 1-9, 2015
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
K Patel, M Foretz, A Marion, DG Campbell, R Gourlay, N Boudaba, ...
Nature communications 5 (1), 1-16, 2014
Resolving the paradox of hepatic insulin resistance
D Santoleri, PM Titchenell
Cellular and molecular gastroenterology and hepatology 7 (2), 447-456, 2019
Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood–retinal barrier dysfunction
PM Titchenell, CM Lin, JM Keil, JM Sundstrom, CD Smith, DA Antonetti
Biochemical Journal 446 (3), 455-467, 2012
The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis
N Jaiswal, MG Gavin, WJ Quinn III, TS Luongo, RG Gelfer, JA Baur, ...
Molecular metabolism 28, 1-13, 2019
Physiological suppression of lipotoxic liver damage by complementary actions of HDAC3 and SCAP/SREBP
R Papazyan, Z Sun, YH Kim, PM Titchenell, DA Hill, W Lu, M Damle, ...
Cell metabolism 24 (6), 863-874, 2016
Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy
PM Titchenell, DA Antonetti
Diabetes 62 (6), 1808-1815, 2013
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
H Jang, GY Lee, CP Selby, G Lee, YG Jeon, JH Lee, KKY Cheng, ...
Nature communications 7 (1), 1-14, 2016
mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion
WJ Quinn, M Wan, SV Shewale, R Gelfer, DJ Rader, MJ Birnbaum, ...
The Journal of clinical investigation 127 (11), 4207-4215, 2017
Shared PPARα/γ target genes regulate brown adipocyte thermogenic function
Y Shen, Y Su, FJ Silva, AH Weller, J Sostre-Colón, PM Titchenell, ...
Cell Reports 30 (9), 3079-3091. e5, 2020
Early B cell factor activity controls developmental and adaptive thermogenic gene programming in adipocytes
AR Angueira, SN Shapira, J Ishibashi, S Sampat, J Sostre-Colón, ...
Cell reports 30 (9), 2869-2878. e4, 2020
MondoA drives muscle lipid accumulation and insulin resistance
B Ahn, S Wan, N Jaiswal, RB Vega, DE Ayer, PM Titchenell, X Han, ...
JCI insight 4 (15), 2019
Inhibition of atypical protein kinase C reduces inflammation-induced retinal vascular permeability
C Lin, PM Titchenell, JM Keil, A Garcia-Ocaña, MT Bolinger, SF Abcouwer, ...
The American journal of pathology 188 (10), 2392-2405, 2018
Synthesis and structure–activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors
PM Titchenell, HDH Showalter, JF Pons, AJ Barber, Y Jin, DA Antonetti
Bioorganic & medicinal chemistry letters 23 (10), 3034-3038, 2013
siRNA-mediated knockdown of h-caldesmon in vascular smooth muscle
EM Smolock, DM Trappanese, S Chang, T Wang, P Titchenell, ...
American Journal of Physiology-Heart and Circulatory Physiology 297 (5 …, 2009
The Polycomb protein, Bmi1, regulates insulin sensitivity
CE Cannon, PM Titchenell, DN Groff, A El Ouaamari, RN Kulkarni, ...
Molecular metabolism 3 (8), 794-802, 2014
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