Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis CA Koczor, KM Saville, JF Andrews, J Clark, Q Fang, J Li, ... Cell reports 37 (5), 2021 | 40 | 2021 |
NAD+-mediated regulation of mammalian base excision repair KM Saville, J Clark, A Wilk, GD Rogers, JF Andrews, CA Koczor, ... DNA repair 93, 102930, 2020 | 29 | 2020 |
NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells J Li, K M. Saville, M Ibrahim, X Zeng, S McClellan, A Angajala, A Beiser, ... NAR cancer 3 (4), zcab044, 2021 | 14 | 2021 |
Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD+ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase J Li, CA Koczor, KM Saville, F Hayat, A Beiser, S McClellan, ME Migaud, ... Cancers 14 (15), 3572, 2022 | 8 | 2022 |
Live cell detection of poly (ADP-ribose) for use in genetic and genotoxic compound screens CA Koczor, AJ Haider, KM Saville, J Li, JF Andrews, AV Beiser, RW Sobol Cancers 14 (15), 3676, 2022 | 5 | 2022 |
Quantitative analysis of nuclear poly (ADP-ribose) dynamics in response to laser-induced DNA damage CA Koczor, KM Saville, RQ Al-Rahahleh, JF Andrews, J Li, RW Sobol Poly (ADP-Ribose) Polymerase: Methods and Protocols, 43-59, 2022 | 1 | 2022 |
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity KM Saville, RQ Al-Rahahleh, AH Siddiqui, ME Andrews, WP Roos, ... DNA Repair, 103700, 2024 | | 2024 |
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage RQ Al-Rahahleh, KM Saville, JF Andrews, Z Wu, CA Koczor, RW Sobol bioRxiv, 2023.12. 29.573650, 2023 | | 2023 |
The Role of PARP1 and NAD+ Bioavailability in Base Excision and Single-Strand Break Repair KM Saville University of South Alabama, 2022 | | 2022 |
Sensitivity of melanoma cells to a novel class of Ras inhibitors KM Saville, K Lee, TE Mattox, X Chen, J Valiyaveettil, K Berry, ... Cancer Research 77 (13_Supplement), 5166-5166, 2017 | | 2017 |
Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven … B Zhu, X Chen, J Valiyaveettil, J Canzoneri, K Lee, K Saville, K Berry, ... Cancer Research 77 (13_Supplement), 4972-4972, 2017 | | 2017 |