A. S. Lewin

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198319841985198619871988198919901991199219931994199519961997199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202263 44 34 34 31 32 27 23 34 36 14 47 58 51 45 43 74 112 113 145 217 192 192 226 232 286 280 330 410 560 564 592 688 682 669 665 644 772 883 468

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Cristhian IldefonsoResearch Assistant Professor , University of FloridaVerified email at ufl.edu
Sanford L. BoyePowell Gene Therapy Center, Department of Pediatrics, University of FloridaVerified email at ufl.edu
Manas R. Biswal, Ph.D.University of South Florida, Tampa, FL, USA.Verified email at usf.edu
Artur CideciyanResearch Professor of Ophthalmology, University of PennsylvaniaVerified email at mail.med.upenn.edu
Samuel G. JacobsonProfessor of Ophthalmology, University of PennsylvaniaVerified email at mail.med.upenn.edu
maria grantProfessor of Ophthalmology, Indiana UniversityVerified email at iupui.edu
William BeltranProfessor of Ophthalmology- University of PennsylvaniaVerified email at vet.upenn.edu
Chulbul M. AhmedUniversity of FloridaVerified email at ufl.edu
Oleg GorbatyukResearch Associate Professor, University of Alabama at BirminghamVerified email at uab.edu
Shannon BoyeAssociate Professor, University of FloridaVerified email at ufl.edu
Fredric ManfredssonBarrow Neurological InstituteVerified email at barrowneuro.org
Vittorio porciattiProfessor, Bascom Palmer Eye Institute, Miami, FLVerified email at med.miami.edu
Richard I. MorimotoBill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, NorthwesternVerified email at northwestern.edu
Barry J. ByrneUniversity of FloridaVerified email at ufl.edu
Mohan K RaizadaDistinguished Professor of Physiology, University of FloridaVerified email at ufl.edu
Valerio CarelliDepartment of Biomedical and Neuromotor Sciences, University of BolognaVerified email at unibo.it
Sriniwas SriramPostdoctoral fellow, Harvard Medical SchoolVerified email at meei.harvard.edu
CORINNA BURGERAssociate Professor in Neurology, University of WisconsinVerified email at wisc.edu
Catherine Bowes RickmanProfessor of Ophthalmology and of Cell BiologyVerified email at duke.edu
Darin J. FalkAssistant Professor, University of FloridaVerified email at ufl.edu

A. S. Lewin

University of Florida

Verified email at ufl.edu - Homepage

mitochondria gene therapy retinal degeneration age related macular degeneration cardivascular disease


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Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa AS Lewin, KA Drenser, WW Hauswirth, S Nishikawa, D Yasumura, ... Nature medicine 4 (8), 967-971, 1998	495	1998
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors H Petrs-Silva, A Dinculescu, Q Li, SH Min, V Chiodo, JJ Pang, L Zhong, ... Molecular therapy 17 (3), 463-471, 2009	434	2009
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD SK Mitter, C Song, X Qi, H Mao, H Rao, D Akin, A Lewin, M Grant, ... Autophagy 10 (11), 1989-2005, 2014	339	2014
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice E Rodriguez-Lebron, EM Denovan-Wright, K Nash, AS Lewin, RJ Mandel Molecular therapy 12 (4), 618-633, 2005	306	2005
A comprehensive review of retinal gene therapy SE Boye, SL Boye, AS Lewin, WW Hauswirth Molecular therapy 21 (3), 509-519, 2013	303	2013
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa WA Beltran, AV Cideciyan, AS Lewin, S Iwabe, H Khanna, A Sumaroka, ... Proceedings of the National Academy of Sciences 109 (6), 2132-2137, 2012	286	2012
Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy J Guy, X Qi, F Pallotti, EA Schon, G Manfredi, V Carelli, A Martinuzzi, ... Annals of Neurology: Official Journal of the American Neurological …, 2002	285	2002
Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 MS Gorbatyuk, T Knox, MM LaVail, OS Gorbatyuk, SM Noorwez, ... Proceedings of the National Academy of Sciences 107 (13), 5961-5966, 2010	267	2010
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina H Petrs-Silva, A Dinculescu, Q Li, WT Deng, J Pang, SH Min, V Chiodo, ... Molecular Therapy 19 (2), 293-301, 2011	255	2011
Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy MM LaVail, D Yasumura, MT Matthes, KA Drenser, JG Flannery, AS Lewin, ... Proceedings of the National Academy of Sciences 97 (21), 11488-11493, 2000	249	2000
SOD2 knockdown mouse model of early AMD V Justilien, JJ Pang, K Renganathan, X Zhan, JW Crabb, SR Kim, ... Investigative ophthalmology & visual science 48 (10), 4407-4420, 2007	236	2007
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ... Molecular Therapy 18 (8), 1450-1457, 2010	203	2010
[48] Production and purification of recombinant adeno-associated virus WW Hauswirth, AS Lewin, S Zolotukhin, N Muzyczka Methods in enzymology 316, 743-761, 2000	202	2000
Ribozyme gene therapy: applications for molecular medicine AS Lewin, WW Hauswirth Trends in molecular medicine 7 (5), 221-228, 2001	188	2001
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy A Verma, Z Shan, B Lei, L Yuan, X Liu, T Nakagawa, MB Grant, AS Lewin, ... Molecular therapy 20 (1), 28-36, 2012	177	2012
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease MS Gorbatyuk, A Shabashvili, W Chen, C Meyers, LF Sullivan, M Salganik, ... Molecular Therapy 20 (7), 1327-1337, 2012	165	2012
Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis X Qi, AS Lewin, L Sun, WW Hauswirth, J Guy Journal of Biological Chemistry 281 (42), 31950-31962, 2006	152	2006
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model H Yu, RD Koilkonda, TH Chou, V Porciatti, SS Ozdemir, V Chiodo, ... Proceedings of the National Academy of Sciences 109 (20), E1238-E1247, 2012	150	2012
Citrate synthase encoded by the CIT2 gene of Saccharomyces cerevisiae is peroxisomal AS Lewin, V Hines, GM Small Molecular and Cellular Biology 10 (4), 1399-1405, 1990	143	1990
Cytoplasmically made subunits of yeast mitochondrial F1-ATPase and cytochrome c oxidase are synthesized as individual precursors, not as polyproteins. AS Lewin, I Gregor, TL Mason, N Nelson, G Schatz Proceedings of the National Academy of Sciences 77 (7), 3998-4002, 1980	142	1980

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