| Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism LR Band, DM Wells, A Larrieu, J Sun, AM Middleton, AP French, ... Proceedings of the National Academy of Sciences 109 (12), 4668-4673, 2012 | 344 | 2012 |
| Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling AM Middleton, S Úbeda-Tomás, J Griffiths, T Holman, P Hedden, ... Proceedings of the National Academy of Sciences 109 (19), 7571-7576, 2012 | 149 | 2012 |
| Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway J Yin, J Guo, Q Zhang, L Cui, L Zhang, T Zhang, J Zhao, J Li, A Middleton, ... Toxicology in vitro 51, 1-10, 2018 | 141 | 2018 |
| Sequential induction of auxin efflux and influx carriers regulates lateral root emergence B Péret, AM Middleton, AP French, A Larrieu, A Bishopp, M Njo, DM Wells, ... Molecular systems biology 9 (1), 699, 2013 | 129 | 2013 |
| Growth-induced hormone dilution can explain the dynamics of plant root cell elongation LR Band, S Úbeda-Tomás, RJ Dyson, AM Middleton, TC Hodgman, ... Proceedings of the National Academy of Sciences 109 (19), 7577-7582, 2012 | 119 | 2012 |
| A next-generation risk assessment case study for coumarin in cosmetic products MT Baltazar, S Cable, PL Carmichael, R Cubberley, T Cull, M Delagrange, ... Toxicological Sciences 176 (1), 236-252, 2020 | 107 | 2020 |
| Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling Q Zhang, J Li, A Middleton, S Bhattacharya, RB Conolly Frontiers in public health 6, 261, 2018 | 72 | 2018 |
| A continuum approximation to an off-lattice individual-cell based model of cell migration and adhesion AM Middleton, C Fleck, R Grima Journal of theoretical biology 359, 220-232, 2014 | 71 | 2014 |
| Mathematical Modelling of the Aux/IAA Negative Feedback Loop AM Middleton, JR King, MJ Bennett, MR Owen Bulletin of mathematical biology 72, 1383-1407, 2010 | 67 | 2010 |
| Identifying and characterizing stress pathways of concern for consumer safety in next-generation risk assessment S Hatherell, MT Baltazar, J Reynolds, PL Carmichael, M Dent, H Li, ... Toxicological Sciences 176 (1), 11-33, 2020 | 50 | 2020 |
| Modeling regulatory networks to understand plant development: small is beautiful AM Middleton, E Farcot, MR Owen, T Vernoux The Plant Cell 24 (10), 3876-3891, 2012 | 41 | 2012 |
| An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors D Stichel, AM Middleton, BF Müller, S Depner, U Klingmüller, K Breuhahn, ... NPJ systems biology and applications 3 (1), 5, 2017 | 34 | 2017 |
| Data-driven modeling of intracellular auxin fluxes indicates a dominant role of the ER in controlling nuclear auxin uptake AM Middleton, C Dal Bosco, P Chlap, R Bensch, H Harz, F Ren, ... Cell reports 22 (11), 3044-3057, 2018 | 33 | 2018 |
| Are non-animal systemic safety assessments protective? A toolbox and workflow AM Middleton, J Reynolds, S Cable, MT Baltazar, H Li, S Bevan, ... Toxicological Sciences 189 (1), 124-147, 2022 | 25 | 2022 |
| Ready for regulatory use: NAMs and NGRA for chemical safety assurance PL Carmichael, MT Baltazar, S Cable, S Cochrane, M Dent, H Li, ... ALTEX-Alternatives to animal experimentation 39 (3), 359-366, 2022 | 23 | 2022 |
| Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling–A case study of … H Li, H Yuan, A Middleton, J Li, B Nicol, P Carmichael, J Guo, S Peng, ... Toxicology in vitro 74, 105171, 2021 | 16 | 2021 |
| Flutamide induces hepatic cell death and mitochondrial dysfunction via inhibition of Nrf2‐mediated heme oxygenase‐1 L Zhang, J Guo, Q Zhang, W Zhou, J Li, J Yin, L Cui, T Zhang, J Zhao, ... Oxidative medicine and cellular longevity 2018 (1), 8017073, 2018 | 16 | 2018 |
| Case studies in cellular stress: Defining adversity/adaptation tipping points A Middleton, S Cooper, T Cull, R Stark, Y Adeleye, K Boekelheide, ... Applied In Vitro Toxicology 3 (2), 199-210, 2017 | 10 | 2017 |
| Wave pinning and spatial patterning in a mathematical model of Antivin/Lefty–Nodal signalling AM Middleton, JR King, M Loose Journal of Mathematical Biology 67, 1393-1424, 2013 | 9 | 2013 |
| Bistability in a model of mesoderm and anterior mesendoderm specification in Xenopus laevis AM Middleton, JR King, M Loose Journal of theoretical biology 260 (1), 41-55, 2009 | 9 | 2009 |
