Gabriel Helmlinger
Gabriel Helmlinger
Vice-President, Biorchestra
Verified email at
Cited by
Cited by
Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
G Helmlinger, F Yuan, M Dellian, RK Jain
Nature medicine 3 (2), 177-182, 1997
Solid stress inhibits the growth of multicellular tumor spheroids
G Helmlinger, PA Netti, HC Lichtenbeld, RJ Melder, RK Jain
Nature biotechnology 15 (8), 778-783, 1997
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
G Helmlinger, A Sckell, M Dellian, NS Forbes, RK Jain
Clinical Cancer Research 8 (4), 1284-1291, 2002
Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis
KM Hallow, G Helmlinger, PJ Greasley, JJV McMurray, DW Boulton
Diabetes, Obesity and Metabolism 20 (3), 479-487, 2018
Effects of pulsatile flow on cultured vascular endothelial cell morphology
G Helmlinger, RV Geiger, S Schreck, RM Nerem
Formation of endothelial cell networks
G Helmlinger, M Endo, N Ferrara, L Hlatky, RK Jain
Nature 405 (6783), 139-141, 2000
Calcium responses of endothelial cell monolayers subjected to pulsatile and steady laminar flow differ
G Helmlinger, BC Berk, RM Nerem
American Journal of Physiology-Cell Physiology 269 (2), C367-C375, 1995
Pulsatile and steady flow-induced calcium oscillations in single cultured endothelial cells
G Helmlinger, BC Berk, RM Nerem
Journal of vascular research 33 (5), 360-369, 1996
A mechanistic tumor penetration model to guide antibody drug conjugate design
C Vasalou, G Helmlinger, B Gomes
PloS one 10 (3), e0118977, 2015
Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis
KM Hallow, Y Gebremichael, G Helmlinger, V Vallon
American Journal of Physiology-Renal Physiology 312 (5), F819-F835, 2017
Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients
M Dellian, G Helmlinger, F Yuan, RK Jain
British journal of cancer 74 (8), 1206-1215, 1996
Radiation and PD-(L) 1 treatment combinations: immune response and dose optimization via a predictive systems model
Y Kosinsky, SJ Dovedi, K Peskov, V Voronova, L Chu, H Tomkinson, ...
Journal for immunotherapy of cancer 6, 1-15, 2018
Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart
D Bottino, RC Penland, A Stamps, M Traebert, B Dumotier, A Georgieva, ...
Progress in biophysics and molecular biology 90 (1-3), 414-443, 2006
Evaluation of renal and cardiovascular protection mechanisms of SGLT2 inhibitors: model-based analysis of clinical data
KM Hallow, PJ Greasley, G Helmlinger, L Chu, HJ Heerspink, DW Boulton
American Journal of Physiology-Renal Physiology 315 (5), F1295-F1306, 2018
Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs
A Kuttler, T Dimke, S Kern, G Helmlinger, D Stanski, LA Finelli
Journal of pharmacokinetics and pharmacodynamics 37, 629-644, 2010
Quantitative systems pharmacology: an exemplar model‐building workflow with applications in cardiovascular, metabolic, and oncology drug development
G Helmlinger, V Sokolov, K Peskov, KM Hallow, Y Kosinsky, V Voronova, ...
CPT: pharmacometrics & systems pharmacology 8 (6), 380-395, 2019
A physiology-based model of bile acid distribution and metabolism under healthy and pathologic conditions in human beings
V Voronova, V Sokolov, A Al-Khaifi, S Straniero, C Kumar, K Peskov, ...
Cellular and Molecular Gastroenterology and Hepatology 10 (1), 149-170, 2020
An integrated approach for inference and mechanistic modeling for advancing drug development
SV Aksenov, B Church, A Dhiman, A Georgieva, R Sarangapani, ...
FEBS letters 579 (8), 1878-1883, 2005
Quantitative mechanistic modeling in support of pharmacological therapeutics development in immuno-oncology
K Peskov, I Azarov, L Chu, V Voronova, Y Kosinsky, G Helmlinger
Frontiers in immunology 10, 450826, 2019
Comparison of the urinary glucose excretion contributions of SGLT2 and SGLT1: A quantitative systems pharmacology analysis in healthy individuals and patients with type 2 …
T Yakovleva, V Sokolov, L Chu, W Tang, PJ Greasley, H Peilot Sjögren, ...
Diabetes, Obesity and Metabolism 21 (12), 2684-2693, 2019
The system can't perform the operation now. Try again later.
Articles 1–20