| Transfer-PCR (TPCR): a highway for DNA cloning and protein engineering A Erijman, A Dantes, R Bernheim, JM Shifman, Y Peleg Journal of structural biology 175 (2), 171-177, 2011 | 187 | 2011 |
| Heme redox potential control in de novo designed four-α-helix bundle proteins JM Shifman, BR Gibney, RE Sharp, PL Dutton Biochemistry 39 (48), 14813-14821, 2000 | 179 | 2000 |
| Computational design of an integrin I domain stabilized in the open high affinity conformation M Shimaoka, JM Shifman, H Jing, J Takagi, SL Mayo, TA Springer Nature structural biology 7 (8), 674-678, 2000 | 178 | 2000 |
| Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums JM Shifman, MH Choi, S Mihalas, SL Mayo, MB Kennedy Proceedings of the National Academy of Sciences 103 (38), 13968-13973, 2006 | 168 | 2006 |
| Modulating calmodulin binding specificity through computational protein design JM Shifman, SL Mayo Journal of molecular biology 323 (3), 417-423, 2002 | 156 | 2002 |
| Exploring the origins of binding specificity through the computational redesign of calmodulin JM Shifman, SL Mayo Proceedings of the National Academy of Sciences 100 (23), 13274-13279, 2003 | 139 | 2003 |
| How structure defines affinity in protein-protein interactions A Erijman, E Rosenthal, JM Shifman PLOS one 9 (10), e110085, 2014 | 106 | 2014 |
| Functionalized de novo designed proteins: mechanism of proton coupling to oxidation/reduction in heme protein maquettes JM Shifman, CC Moser, WA Kalsbeck, DF Bocian, PL Dutton Biochemistry 37 (47), 16815-16827, 1998 | 82 | 1998 |
| What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf D Filchtinski, O Sharabi, A Rüppel, IR Vetter, C Herrmann, JM Shifman Journal of molecular biology 399 (3), 422-435, 2010 | 77 | 2010 |
| Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution V Arkadash, G Yosef, J Shirian, I Cohen, Y Horev, M Grossman, I Sagi, ... Journal of Biological Chemistry 292 (8), 3481-3495, 2017 | 69 | 2017 |
| Tradeoff between stability and multispecificity in the design of promiscuous proteins M Fromer, JM Shifman PLoS computational biology 5 (12), e1000627, 2009 | 62 | 2009 |
| Computational design of calmodulin mutants with up to 900-fold increase in binding specificity E Yosef, R Politi, MH Choi, JM Shifman Journal of molecular biology 385 (5), 1470-1480, 2009 | 60 | 2009 |
| Multispecific recognition: mechanism, evolution, and design A Erijman, Y Aizner, JM Shifman Biochemistry 50 (5), 602-611, 2011 | 58 | 2011 |
| Dead‐end elimination for multistate protein design C Yanover, M Fromer, JM Shifman Journal of computational chemistry 28 (13), 2122-2129, 2007 | 56 | 2007 |
| Protein engineering by combined computational and in vitro evolution approaches L Rosenfeld, M Heyne, JM Shifman, N Papo Trends in biochemical sciences 41 (5), 421-433, 2016 | 49 | 2016 |
| Affinity-and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs O Sharabi, J Shirian, M Grossman, M Lebendiker, I Sagi, J Shifman PloS one 9 (4), e93712, 2014 | 45 | 2014 |
| Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21 I Leung, A Dekel, JM Shifman, SS Sidhu Proceedings of the National Academy of Sciences 113 (31), 8705-8710, 2016 | 40 | 2016 |
| Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14 J Shirian, V Arkadash, I Cohen, T Sapir, ES Radisky, N Papo, JM Shifman FEBS letters 592 (7), 1122-1134, 2018 | 33 | 2018 |
| RAS/Effector interactions from structural and biophysical perspective A Erijman, JM Shifman Mini Rev Med Chem. 16 (5), 370-375, 2016 | 32 | 2016 |
| Triathlon for energy functions: Who is the winner for design of protein–protein interactions? O Sharabi, A Dekel, JM Shifman Proteins: Structure, Function, and Bioinformatics 79 (5), 1487-1498, 2011 | 28 | 2011 |
Mary B. KennedyAllen and Lenabelle Davis Professor of Biology, California Institute of TechnologyVerified email at its.caltech.edu
