Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy … J Datta, X Dai, A Bianchi, IDC Silva, S Mehra, VT Garrido, P Lamichhane, ... Gastroenterology 163 (6), 1593-1612, 2022 | 55 | 2022 |
Targeting tumor–stromal IL6/STAT3 signaling through IL1 receptor inhibition in pancreatic Cancer AR Dosch, S Singh, X Dai, S Mehra, IDC Silva, A Bianchi, S Srinivasan, ... Molecular cancer therapeutics 20 (11), 2280-2290, 2021 | 28 | 2021 |
Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer A Bianchi, I De Castro Silva, NU Deshpande, S Singh, S Mehra, ... Cancer discovery 13 (6), 1428-1453, 2023 | 25 | 2023 |
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer J Datta, A Bianchi, I De Castro Silva, NU Deshpande, LL Cao, S Mehra, ... Oncogene 41 (28), 3640-3654, 2022 | 18 | 2022 |
Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized … I de Castro Silva, A Bianchi, NU Deshpande, P Sharma, S Mehra, ... Elife 11, e78921, 2022 | 15 | 2022 |
Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling S Mehra, S Srinivasan, S Singh, Z Zhou, V Garrido, IDC Silva, TM Totiger, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 323 (4 …, 2022 | 10 | 2022 |
Stalled at the intersection: insurance status and disparities in post-mastectomy breast reconstruction O Friedman-Eldar, J Burke, I de Castro Silva, CC Baumrucker, F Valle, ... Breast cancer research and treatment 194 (2), 327-335, 2022 | 6 | 2022 |
Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers AR Dosch, WK Chatila, Y Ban, A Bianchi, NU Deshpande, IDC Silva, ... Oncotarget 12 (20), 2104, 2021 | 5 | 2021 |
Racial disparity in pathologic response following neoadjuvant chemotherapy in resected pancreatic cancer: a multi-institutional analysis from the Central Pancreatic Consortium I Ogobuiro, AL Collier, K Khan, I de Castro Silva, D Kwon, GC Wilson, ... Annals of surgical oncology 30 (3), 1485-1494, 2023 | 4 | 2023 |
Remodeling of stromal immune microenvironment by urolithin A improves survival with immune checkpoint blockade in pancreatic cancer S Mehra, VT Garrido, AR Dosch, P Lamichhane, S Srinivasan, SP Singh, ... Cancer research communications 3 (7), 1224-1236, 2023 | 2 | 2023 |
Persistent and interdependent: Racial disparities and their mechanisms in postmastectomy breast reconstruction J Burke, O Friedman-Eldar, G Halfteck, I de Castro Silva, CC Baumrucker, ... Surgery 172 (1), 25-30, 2022 | 2 | 2022 |
Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer J Datta, X Dai, A Bianchi, I De Castro Silva, S Mehra, V Garrido, ... bioRxiv, 2021.03. 07.434236, 2021 | 2 | 2021 |
Rechallenge with combination ipilimumab and anti-PD-1 (IPI+ PD1) in metastatic melanoma after acquired resistance to IPI+ PD1 immunotherapy A Hepner, MS Carlino, DB Johnson, CL Gérard, S Lo, L Pallan, ID Silva, ... Annals of Oncology 30, v551-v552, 2019 | 2 | 2019 |
Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer SP Singh, AR Dosch, S Mehra, I De Castro Silva, A Bianchi, VT Garrido, ... Cancer Research 84 (8), 1320-1332, 2024 | 1 | 2024 |
Surgical and oncologic outcomes with intraoperative radiation therapy for early breast cancer O Friedman-Eldar, C Layton, I De Castro Silva, MG Moller, A Allen, ... The American Surgeon™ 89 (4), 920-926, 2023 | 1 | 2023 |
Protective Effects of Urolithin A on Alcoholic Chronic Pancreatitis via Inhibiting PI3K/AKT/mTOR Signaling Pathway S Mehra, S Srinivasan, X Dai, A Dosch, S Singh, A Bianchi, I Silva, ... Pancreas 50 (7), 1082-1082, 2021 | 1 | 2021 |
P5. Impact Of Lymphatic Microsurgical Preventive Healing Approach (LYMPHA) On Postoperative Complication Rates In Immediate Prosthetic Based Breast Reconstruction: A … A Desai, E Finkelstein, IDC Silva, M Clark, SB Kesmodel, KE Rojas, ... Plastic and Reconstructive Surgery–Global Open 12 (S5), 41, 2024 | | 2024 |
Patient Selection and Outcomes with Hepatic Artery Infusion Chemotherapy (HAIC) in Unresectable Colorectal Liver Metastasis (uCRLM) at a Tertiary Referral Center EM Dickey, KL Koch, H Amirian, F Alessandrino, J Kronenfeld, IDC Silva, ... ANNALS OF SURGICAL ONCOLOGY 31 (1), S204-S204, 2024 | | 2024 |
Disrupting TNFR2 Signaling Improves Chemotherapy sensitivity in Pancreatic Cancer H Amirian, Bianc-, Anna, I, K Rajkumar, A-am, Andrew, IDC Silva, ... ANNALS OF SURGICAL ONCOLOGY 31 (1), S29-S29, 2024 | | 2024 |
A novel mechanism of immunotherapy sensitivity following platinum chemotherapy resistance in pancreatic cancer patients with germline homologous recombination deficiency I Ogobuiro, K Rajkumar, A Bianchi, L Caeiro, H Amirian, L Nivelo, ... ANNALS OF SURGICAL ONCOLOGY 31 (1), S24-S25, 2024 | | 2024 |