David Barbie
David Barbie
Dana-Farber Cancer Institute
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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ...
Nature 462 (7269), 108-112, 2009
Defining T cell states associated with response to checkpoint immunotherapy in melanoma
M Sade-Feldman, K Yizhak, SL Bjorgaard, JP Ray, CG de Boer, ...
Cell 175 (4), 998-1013. e20, 2018
Mechanisms of resistance to immune checkpoint inhibitors
RW Jenkins, DA Barbie, KT Flaherty
British journal of cancer 118 (1), 9-16, 2018
A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade
L Jerby-Arnon, P Shah, MS Cuoco, C Rodman, MJ Su, JC Melms, ...
Cell 175 (4), 984-997. e24, 2018
Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
C Scholl, S Fröhling, IF Dunn, AC Schinzel, DA Barbie, SY Kim, SJ Silver, ...
Cell 137 (5), 821-834, 2009
Highly parallel identification of essential genes in cancer cells
B Luo, HW Cheung, A Subramanian, T Sharifnia, M Okamoto, X Yang, ...
Proceedings of the National Academy of Sciences 105 (51), 20380-20385, 2008
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
KM Vasudevan, DA Barbie, MA Davies, R Rabinovsky, CJ McNear, ...
Cancer cell 16 (1), 21-32, 2009
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine
EM Van Allen, N Wagle, P Stojanov, DL Perrin, K Cibulskis, S Marlow, ...
Nature medicine 20 (6), 682-688, 2014
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell ActivationCDK4/6 Inhibition Enhances the Antitumor T-cell Response
J Deng, ES Wang, RW Jenkins, S Li, R Dries, K Yates, S Chhabra, ...
Cancer discovery 8 (2), 216-233, 2018
NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription
J Zhao, BK Kennedy, BD Lawrence, DA Barbie, AG Matera, JA Fletcher, ...
Genes & development 14 (18), 2283-2297, 2000
STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor MicroenvironmentImmunosuppressive …
S Koyama, EA Akbay, YY Li, AR Aref, F Skoulidis, GS Herter-Sprie, ...
Cancer research 76 (5), 999-1008, 2016
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor
CL Christensen, N Kwiatkowski, BJ Abraham, J Carretero, F Al-Shahrour, ...
Cancer cell 26 (6), 909-922, 2014
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
D Miao, CA Margolis, NI Vokes, D Liu, A Taylor-Weiner, SM Wankowicz, ...
Nature genetics 50 (9), 1271-1281, 2018
Nuclear organization of DNA replication in primary mammalian cells
BK Kennedy, DA Barbie, M Classon, N Dyson, E Harlow
Genes & development 14 (22), 2855-2868, 2000
Ex vivo profiling of PD-1 blockade using organotypic tumor SpheroidsEx vivo profiling of immune checkpoint blockade
RW Jenkins, AR Aref, PH Lizotte, E Ivanova, S Stinson, CW Zhou, ...
Cancer discovery 8 (2), 196-215, 2018
Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
VV Ogryzko, TH Hirai, VR Russanova, DA Barbie, BH Howard
Molecular and cellular biology 16 (9), 5210-5218, 1996
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation
BR Johnson, RT Nitta, RL Frock, L Mounkes, DA Barbie, CL Stewart, ...
Proceedings of the National Academy of Sciences 101 (26), 9677-9682, 2004
Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung CancerSilencing of STING in KRAS-LKB1–Mutant Lung Cancer
S Kitajima, E Ivanova, S Guo, R Yoshida, M Campisi, SK Sundararaman, ...
Cancer discovery 9 (1), 34-45, 2019
RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth …
A Lai, BK Kennedy, DA Barbie, NR Bertos, XJ Yang, MC Theberge, ...
Molecular and cellular biology 21 (8), 2918-2932, 2001
Treatment-induced tumor dormancy through YAP-mediated transcriptional reprogramming of the apoptotic pathway
KJ Kurppa, Y Liu, C To, T Zhang, M Fan, A Vajdi, EH Knelson, Y Xie, ...
Cancer cell 37 (1), 104-122. e12, 2020
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