Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response R Mandal, RM Samstein, KW Lee, JJ Havel, H Wang, C Krishna, ... Science 364 (6439), 485-491, 2019 | 451 | 2019 |
ILC1 confer early host protection at initial sites of viral infection OE Weizman, NM Adams, IS Schuster, C Krishna, Y Pritykin, C Lau, ... Cell 171 (4), 795-808. e12, 2017 | 394 | 2017 |
Immunogenic neoantigens derived from gene fusions stimulate T cell responses W Yang, KW Lee, RM Srivastava, F Kuo, C Krishna, D Chowell, ... Nature medicine 25 (5), 767-775, 2019 | 314 | 2019 |
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy D Chowell*, C Krishna*, F Pierini*, V Makarov, NA Rizvi, F Kuo, ... Nature medicine 25 (11), 1715-1720, 2019 | 237 | 2019 |
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy C Krishna, RG DiNatale, F Kuo, RM Srivastava, L Vuong, D Chowell, ... Cancer cell 39 (5), 662-677. e6, 2021 | 210 | 2021 |
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types D Chowell*, SK Yoo*, C Valero*, A Pastore*, C Krishna, M Lee, D Hoen, ... Nature Biotechnology 40 (4), 499-506, 2022 | 148 | 2022 |
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy RM Samstein*, C Krishna*, X Ma*, X Pei, KW Lee, V Makarov, F Kuo, ... Nature cancer 1 (12), 1188-1203, 2020 | 139 | 2020 |
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12 OE Weizman, E Song, NM Adams, AD Hildreth, L Riggan, C Krishna, ... Nature immunology 20 (8), 1004-1011, 2019 | 89 | 2019 |
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer BG Nixon, F Kuo, LL Ji, M Liu, K Capistrano, M Do, RA Franklin, X Wu, ... Immunity 55 (11), 2044-2058. e5, 2022 | 64 | 2022 |
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity BG Nixon, C Chou, C Krishna, S Dadi, AO Michel, AE Cornish, ... Science immunology 7 (70), eabi8642, 2022 | 56 | 2022 |
Genetic and environmental determinants of human TCR repertoire diversity C Krishna*, D Chowell*, M Gönen, Y Elhanati, TA Chan Immunity & Ageing 17 (1), 1-7, 2020 | 55 | 2020 |
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon L Kong, V Pokatayev, A Lefkovith, GT Carter, EA Creasey, C Krishna, ... Immunity 56 (2), 444-458. e5, 2023 | 47 | 2023 |
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies ER Kansler*, S Dadi*, C Krishna, BG Nixon, EG Stamatiades, M Liu, ... Nature Immunology 23 (6), 904-915, 2022 | 47 | 2022 |
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors DN Khalil, N Suek, LF Campesato, S Budhu, D Redmond, RM Samstein, ... The Journal of clinical investigation 129 (8), 3435-3447, 2019 | 47 | 2019 |
Programme of self-reactive innate-like T cell-mediated cancer immunity C Chou*, X Zhang*, C Krishna, BG Nixon, S Dadi, KJ Capistrano, ... Nature 605 (7908), 139-145, 2022 | 41 | 2022 |
Non-redundant ISGF3 components promote NK cell survival in an auto-regulatory manner during viral infection CD Geary, C Krishna, CM Lau, NM Adams, SV Gearty, Y Pritykin, ... Cell reports 24 (8), 1949-1957. e6, 2018 | 34 | 2018 |
Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation CK Vorkas*, C Krishna*, K Li, J Aubé, DW Fitzgerald, L Mazutis, CS Leslie, ... The Journal of Immunology 208 (5), 1042-1056, 2022 | 31 | 2022 |
High response rate and durability driven by HLA genetic diversity in patients with kidney cancer treated with lenvatinib and pembrolizumab CH Lee, RG DiNatale, D Chowell, C Krishna, V Makarov, C Valero, ... Molecular Cancer Research 19 (9), 1510-1521, 2021 | 23 | 2021 |
Qa-1b Modulates Resistance to Anti–PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing X Zhang, E Sabio, C Krishna, X Ma, J Wang, H Jiang, JJ Havel, TA Chan Molecular Cancer Research 19 (6), 1076-1084, 2021 | 12 | 2021 |
Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation S Dikiy, AG Levine, P Giovanelli, ZM Wang, G Beroshvili, Y Pritykin, ... bioRxiv, 2022.05. 16.492030, 2022 | 4 | 2022 |