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Chirag Krishna
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Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response
R Mandal, RM Samstein, KW Lee, JJ Havel, H Wang, C Krishna, ...
Science 364 (6439), 485-491, 2019
4512019
ILC1 confer early host protection at initial sites of viral infection
OE Weizman, NM Adams, IS Schuster, C Krishna, Y Pritykin, C Lau, ...
Cell 171 (4), 795-808. e12, 2017
3942017
Immunogenic neoantigens derived from gene fusions stimulate T cell responses
W Yang, KW Lee, RM Srivastava, F Kuo, C Krishna, D Chowell, ...
Nature medicine 25 (5), 767-775, 2019
3142019
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
D Chowell*, C Krishna*, F Pierini*, V Makarov, NA Rizvi, F Kuo, ...
Nature medicine 25 (11), 1715-1720, 2019
2372019
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
C Krishna, RG DiNatale, F Kuo, RM Srivastava, L Vuong, D Chowell, ...
Cancer cell 39 (5), 662-677. e6, 2021
2102021
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types
D Chowell*, SK Yoo*, C Valero*, A Pastore*, C Krishna, M Lee, D Hoen, ...
Nature Biotechnology 40 (4), 499-506, 2022
1482022
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy
RM Samstein*, C Krishna*, X Ma*, X Pei, KW Lee, V Makarov, F Kuo, ...
Nature cancer 1 (12), 1188-1203, 2020
1392020
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
OE Weizman, E Song, NM Adams, AD Hildreth, L Riggan, C Krishna, ...
Nature immunology 20 (8), 1004-1011, 2019
892019
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer
BG Nixon, F Kuo, LL Ji, M Liu, K Capistrano, M Do, RA Franklin, X Wu, ...
Immunity 55 (11), 2044-2058. e5, 2022
642022
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity
BG Nixon, C Chou, C Krishna, S Dadi, AO Michel, AE Cornish, ...
Science immunology 7 (70), eabi8642, 2022
562022
Genetic and environmental determinants of human TCR repertoire diversity
C Krishna*, D Chowell*, M Gönen, Y Elhanati, TA Chan
Immunity & Ageing 17 (1), 1-7, 2020
552020
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon
L Kong, V Pokatayev, A Lefkovith, GT Carter, EA Creasey, C Krishna, ...
Immunity 56 (2), 444-458. e5, 2023
472023
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies
ER Kansler*, S Dadi*, C Krishna, BG Nixon, EG Stamatiades, M Liu, ...
Nature Immunology 23 (6), 904-915, 2022
472022
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors
DN Khalil, N Suek, LF Campesato, S Budhu, D Redmond, RM Samstein, ...
The Journal of clinical investigation 129 (8), 3435-3447, 2019
472019
Programme of self-reactive innate-like T cell-mediated cancer immunity
C Chou*, X Zhang*, C Krishna, BG Nixon, S Dadi, KJ Capistrano, ...
Nature 605 (7908), 139-145, 2022
412022
Non-redundant ISGF3 components promote NK cell survival in an auto-regulatory manner during viral infection
CD Geary, C Krishna, CM Lau, NM Adams, SV Gearty, Y Pritykin, ...
Cell reports 24 (8), 1949-1957. e6, 2018
342018
Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation
CK Vorkas*, C Krishna*, K Li, J Aubé, DW Fitzgerald, L Mazutis, CS Leslie, ...
The Journal of Immunology 208 (5), 1042-1056, 2022
312022
High response rate and durability driven by HLA genetic diversity in patients with kidney cancer treated with lenvatinib and pembrolizumab
CH Lee, RG DiNatale, D Chowell, C Krishna, V Makarov, C Valero, ...
Molecular Cancer Research 19 (9), 1510-1521, 2021
232021
Qa-1b Modulates Resistance to Anti–PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing
X Zhang, E Sabio, C Krishna, X Ma, J Wang, H Jiang, JJ Havel, TA Chan
Molecular Cancer Research 19 (6), 1076-1084, 2021
122021
Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation
S Dikiy, AG Levine, P Giovanelli, ZM Wang, G Beroshvili, Y Pritykin, ...
bioRxiv, 2022.05. 16.492030, 2022
42022
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