Loss of ZnT8 function protects against diabetes by enhanced insulin secretion OP Dwivedi, M Lehtovirta, B Hastoy, V Chandra, NAJ Krentz, S Kleiner, ... Nature genetics 51 (11), 1596-1606, 2019 | 125 | 2019 |
Prioritising causal genes at type 2 diabetes risk loci AK Grotz, AL Gloyn, SK Thomsen Current diabetes reports 17, 1-9, 2017 | 41 | 2017 |
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk AK Rottner, Y Ye, E Navarro-Guerrero, V Rajesh, A Pollner, RJ Bevacqua, ... Nature Genetics 55 (1), 54-65, 2023 | 32* | 2023 |
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function [version 1; peer review: 2 approved, A Grotz, F Abaitua, E Navarro-Guerrero, B Hastoy, D Ebner, A Gloyn Wellcome Open Research 4 (150), 2019 | 26 | 2019 |
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression KK Mattis, NAJ Krentz, C Metzendorf, F Abaitua, AF Spigelman, H Sun, ... Diabetologia, 1-21, 2023 | 9 | 2023 |
A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo B Bestas, S Wimberger, D Degtev, A Madsen, AK Rottner, F Karlsson, ... Nature Communications 14 (1), 5474, 2023 | 6 | 2023 |
Systemic gene therapy with thymosin b4 alleviates glomerular injury in mice WJ Mason, DJ Jafree, G Pomeranz, M Kolatsi-Joannou, AK Rottner, ... Nature Research, 0 | 4 | |
3-LB: The Type 2 Diabetes-Associated Transcription Factor RREB1 Affects Beta-Cell Function and Development KK Mattis, F Abaitua, A Grotz, A Wesolowska-Andersen, ... Diabetes 68 (Supplement 1), 2019 | 2 | 2019 |
Pooled CRISPR KO screens for target identification A Grotz, S Deswal Genome Editing in Drug Discovery, 113-125, 2022 | 1 | 2022 |
From 61 Type-2 diabetes genes to 2: Three in vivo perturbation screening steps highlight sirt1 and poldip2 as T2D genes E Mujica, H Zhang, A Emmanouilidou, N Cook, C Metzendorf, ... | | 2024 |
220-LB: Characterizing the Role of 99 Cardiometabolic Candidate Genes Using CRISPR/Cas9, In Vivo Imaging, and Deep Learning in Zebrafish Larvae E MUJICA, H ZHANG, A EMMANOUILIDOU, E MAZZAFERRO, N COOK, ... Diabetes 72 (Supplement_1), 2023 | | 2023 |
2050-P: A Multiomics Investigation of a Patient-Derived HNF-1A MODY IPSC Disease Model Reveals Insights into Its Role in Pancreatic Islet Development and Function C Duff, RR Jensen, M Perez-Alcantara, M Rasmussen, A Grotz, M Jansen, ... Diabetes 69 (Supplement_1), 2020 | | 2020 |
Identifying genes involved in beta cell dysfunction using high-throughput genetic and genomic approaches AK Grotz University of Oxford, 2020 | | 2020 |
3-LB: The Type 2 Diabetes-Associated Transcription Factor RREB1 Affects Beta-Cell Function and Development KK Mattis, F Abaitua, A Grotz, A Wesolowska-Andersen, ... Diabetes 68 (Supplement 1), 2019 | | 2019 |
25-OR: Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus S Sengupta, LL Bonnycastle, B Hastoy, A Grotz, MM Umapathysivam, ... Diabetes 68 (Supplement_1), 2019 | | 2019 |