| A new strategy for site-specific alkylation of DNA using oligonucleotides containing an abasic site and alkylating probes N Sato, G Tsuji, Y Sasaki, A Usami, T Moki, K Onizuka, K Yamada, ... Chemical Communications 51 (80), 14885-14888, 2015 | 18 | 2015 |
| Synthesis of 5′-Terminal Capped Oligonucleotides Using O–N Phosphoryl Migration of Phosphoramidite Derivatives A Ohkubo, N Tago, A Yokouchi, Y Nishino, K Yamada, H Tsunoda, K Seio, ... Organic letters 14 (1), 10-13, 2012 | 17 | 2012 |
| Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids K Onizuka, ME Hazemi, N Sato, G Tsuji, S Ishikawa, M Ozawa, K Tanno, ... Nucleic acids research 47 (13), 6578-6589, 2019 | 16 | 2019 |
| Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection VN Hariharan, M Shin, CW Chang, D O’Reilly, A Biscans, K Yamada, ... Proceedings of the National Academy of Sciences 120 (11), e2219523120, 2023 | 15 | 2023 |
| Nucleotide sugar pucker preference mitigates excision by HIV-1 RT K Yamada, AS Wahba, JA Bernatchez, T Ilina, S Martínez-Montero, ... ACS chemical biology 10 (9), 2024-2033, 2015 | 15 | 2015 |
| Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models F Conroy, R Miller, JF Alterman, MR Hassler, D Echeverria, ... Nature Communications 13 (1), 5802, 2022 | 13 | 2022 |
| Synthesis of peptide nucleic acids (PNA) with a crosslinking agent to RNA and effective inhibition of dicer T Akisawa, K Yamada, F Nagatsugi Bioorganic & Medicinal Chemistry Letters 26 (24), 5902-5906, 2016 | 11 | 2016 |
| Carrier-free gene silencing by amphiphilic nucleic acid conjugates in differentiated intestinal cells E Moroz, SH Lee, K Yamada, F Halloy, S Martínez-Montero, H Jahns, ... Molecular Therapy-Nucleic Acids 5, e364, 2016 | 11 | 2016 |
| Synthesis and Properties of 2′-OMe-RNAs Modified with Cross-Linkable 7-Deazaguanosine Derivatives K Yamada, Y Abe, H Murase, Y Ida, S Hagihara, F Nagatsugi The Journal of Organic Chemistry 83 (16), 8851-8862, 2018 | 9 | 2018 |
| A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds K Yamada, Y Masaki, H Tsunoda, A Ohkubo, K Seio, M Sekine Organic & Biomolecular Chemistry 12 (14), 2255-2262, 2014 | 8 | 2014 |
| Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity K Yamada, S Hildebrand, SM Davis, R Miller, F Conroy, E Sapp, J Caiazzi, ... Nucleic Acids Research 49 (21), 12069-12088, 2021 | 7 | 2021 |
| Synthesis of native-like crosslinked duplex RNA and study of its properties K Onizuka, ME Hazemi, JM Thomas, LR Monteleone, K Yamada, S Imoto, ... Bioorganic & medicinal chemistry 25 (7), 2191-2199, 2017 | 7 | 2017 |
| Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo K Yamada, VN Hariharan, J Caiazzi, R Miller, C Ferguson, E Sapp, ... bioRxiv, 2023.05. 26.542506, 2023 | 5 | 2023 |
| Base recognition of gap sites in DNA–DNA and DNA–RNA duplexes by short oligonucleotides K Yamada, A Ohkubo, Y Esaka, T Kanamori, Y Masaki, K Seio, M Sekine Bioorganic & medicinal chemistry letters 23 (11), 3448-3451, 2013 | 4 | 2013 |
| Synthesis and properties of cross-linkable DNA duplex using 4-amino-2-oxo-6-vinyl-1, 3, 5-triazine K Yamada, S Ishiyama, K Onizuka, F Nagatsugi Tetrahedron 73 (11), 1424-1435, 2017 | 3 | 2017 |
| Design of the Crosslinking Reactions for Nucleic Acids-Binding Protein and Evaluation of the Reactivity K Odaira, K Yamada, S Ishiyama, H Okamura, F Nagatsugi Applied Sciences 10 (21), 7709, 2020 | 2 | 2020 |
| Synthesis and biochemical properties of oligodeoxynucleotides acylated by the chemically stable 2-(trimethylsilyl) benzoyl (TMSBz) group at the 5′ or 3′ terminus K Yamada, H Taguchi, A Ohkubo, K Seio, M Sekine Tetrahedron Letters 51 (39), 5173-5176, 2010 | 2 | 2010 |
| Synthesis and properties of nucleoside derivatives acylated by chemically stable 2-(trimethylsilyl) benzoyl group K Yamada, H Taguchi, A Ohkubo, K Seio, M Sekine Bioorganic & medicinal chemistry 17 (16), 5928-5932, 2009 | 2 | 2009 |
| Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors SR Hildebrand, AK Hedger, K Yamada, JK Watts, A Khvorova RNA 29 (7), 1077-1083, 2023 | 1 | 2023 |
| Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS F Conroy, R Miller, JF Alterman, MR Hassler, D Echeverria, ... bioRxiv, 2022.06. 29.498088, 2022 | | 2022 |
Anastasia KhvorovaUMASS Medical SchoolVerified email at umassmed.edu
