| A protein kinase involved in the regulation of inflammatory cytokine biosynthesis JC Lee, JT Laydon, PC McDonnell, TF Gallagher, S Kumar, D Green, ... Nature 372 (6508), 739-746, 1994 | 4143 | 1994 |
| Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site PR Young, MM McLaughlin, S Kumar, S Kassis, ML Doyle, D McNulty, ... Journal of Biological Chemistry 272 (18), 12116-12121, 1997 | 743 | 1997 |
| Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock … AM Badger, JN Bradbeer, B Votta, JC Lee, JL Adams, DE Griswold Journal of Pharmacology and Experimental Therapeutics 279 (3), 1453-1461, 1996 | 710 | 1996 |
| Inhibition of p38 MAP kinase as a therapeutic strategy JC Lee, S Kumar, DE Griswold, DC Underwood, BJ Votta, JL Adams Immunopharmacology 47 (2-3), 185-201, 2000 | 637 | 2000 |
| Design of amidobenzimidazole STING receptor agonists with systemic activity JM Ramanjulu, GS Pesiridis, J Yang, N Concha, R Singhaus, SY Zhang, ... Nature 564 (7736), 439-443, 2018 | 590 | 2018 |
| Structural basis of inhibitor selectivity in MAP kinases Z Wang, BJ Canagarajah, JC Boehm, S Kassisà, MH Cobb, PR Young, ... Structure 6 (9), 1117-1128, 1998 | 538 | 1998 |
| p38 mitogen-activated protein kinase inhibitors—mechanisms and therapeutic potentials JC Lee, S Kassis, S Kumar, A Badger, JL Adams Pharmacology & therapeutics 82 (2-3), 389-397, 1999 | 497 | 1999 |
| Big opportunities for small molecules in immuno-oncology JL Adams, J Smothers, R Srinivasan, A Hoos Nature reviews Drug discovery 14 (9), 603-622, 2015 | 480 | 2015 |
| SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung DC Underwood, RR Osborn, S Bochnowicz, EF Webb, DJ Rieman, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 279 (5 …, 2000 | 453 | 2000 |
| Inhibition of p38 mitogen‐activated protein kinase provides neuroprotection in cerebral focal ischemia FC Barone, EA Irving, AM Ray, JC Lee, S Kassis, S Kumar, AM Badger, ... Medicinal research reviews 21 (2), 129-145, 2001 | 346 | 2001 |
| Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase S Kumar, MS Jiang, JL Adams, JC Lee Biochemical and biophysical research communications 263 (3), 825-831, 1999 | 346 | 1999 |
| Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date. DE Griswold, JL Adams Medicinal research reviews 16 (2), 181-206, 1996 | 346 | 1996 |
| Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket RJ Gum, MM McLaughlin, S Kumar, Z Wang, MJ Bower, JC Lee, ... Journal of Biological Chemistry 273 (25), 15605-15610, 1998 | 342 | 1998 |
| SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence DC Underwood, RR Osborn, CJ Kotzer, JL Adams, JC Lee, EF Webb, ... Journal of Pharmacology and Experimental Therapeutics 293 (1), 281-288, 2000 | 323 | 2000 |
| Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality D Lee, SA Long, JL Adams, G Chan, KS Vaidya, TA Francis, K Kikly, ... Journal of Biological Chemistry 275 (21), 16007-16014, 2000 | 320 | 2000 |
| Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 AJ King, DR Patrick, RS Batorsky, ML Ho, HT Do, SY Zhang, R Kumar, ... Cancer research 66 (23), 11100-11105, 2006 | 302 | 2006 |
| Disease‐modifying activity of SB 242235, a selective inhibitor of p38 mitogen‐activated protein kinase, in rat adjuvant‐induced arthritis AM Badger, DE Griswold, R Kapadia, S Blake, BA Swift, SJ Hoffman, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2000 | 293 | 2000 |
| SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia FC Barone, EA Irving, AM Ray, JC Lee, S Kassis, S Kumar, AM Badger, ... Journal of Pharmacology and Experimental Therapeutics 296 (2), 312-321, 2001 | 291 | 2001 |
| Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase TF Gallagher, GL Seibel, S Kassis, JT Laydon, MJ Blumenthal, JC Lee, ... Bioorganic & Medicinal Chemistry 5 (1), 49-64, 1997 | 289 | 1997 |
| Potent and selective nonpeptide inhibitors of caspases 3 and 7 D Lee, SA Long, JH Murray, JL Adams, ME Nuttall, DP Nadeau, K Kikly, ... Journal of medicinal chemistry 44 (12), 2015-2026, 2001 | 236 | 2001 |
