| From adaptive licensing to adaptive pathways: delivering a flexible life‐span approach to bring new drugs to patients HG Eichler, LG Baird, R Barker, B Bloechl‐Daum, F Børlum‐Kristensen, ... Clinical Pharmacology & Therapeutics 97 (3), 234-246, 2015 | 251 | 2015 |
| Resonant beam pressure sensor fabricated with silicon fusion bonding K Petersen, F Pourahmadi, J Brown, P Parsons, M Skinner, J Tudor TRANSDUCERS'91: 1991 International Conference on Solid-State Sensors and …, 1991 | 117 | 1991 |
| Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. MR Skinner, JM Marshall The Journal of Physiology 495 (2), 553-560, 1996 | 92 | 1996 |
| Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy CM Patterson, SB Balachander, I Grant, P Pop-Damkov, B Kelly, ... Communications Biology 4 (1), 112, 2021 | 73 | 2021 |
| Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium E Park, GA Gintant, D Bi, D Kozeli, SD Pettit, JB Pierson, M Skinner, ... British journal of pharmacology 175 (4), 606-617, 2018 | 54 | 2018 |
| An analysis of the relationship between preclinical and clinical QT interval-related data CE Pollard, M Skinner, SE Lazic, HM Prior, KM Conlon, JP Valentin, ... Toxicological Sciences 159 (1), 94-101, 2017 | 51 | 2017 |
| Evaluation of drug‐induced QT interval prolongation in animal and human studies: a literature review of concordance HM Vargas, AS Bass, J Koerner, S Matis‐Mitchell, MK Pugsley, M Skinner, ... British journal of pharmacology 172 (16), 4002-4011, 2015 | 51 | 2015 |
| The contribution of VEGF signalling to fostamatinib‐induced blood pressure elevation M Skinner, K Philp, D Lengel, L Coverley, E Lamm Bergström, P Glaves, ... British journal of pharmacology 171 (9), 2308-2320, 2014 | 50 | 2014 |
| The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds L Marks, S Borland, K Philp, L Ewart, P Lainée, M Skinner, S Kirk, ... Toxicology and applied pharmacology 263 (2), 171-183, 2012 | 37 | 2012 |
| Modulation of the vagal bradycardia evoked by stimulation of upper airway receptors by central 5‐HT1 receptors in anaesthetized rabbits SB Dando, MR Skinner, D Jordan, AG Ramage British journal of pharmacology 125 (2), 409-417, 1998 | 29 | 1998 |
| Modulation of reflexly evoked vagal bradycardias by central 5‐HT1A receptors in anaesthetized rabbits MR Skinner, AG Ramage, D Jordan British journal of pharmacology 137 (6), 861-873, 2002 | 28 | 2002 |
| Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin‐dependent protein kinase II L Mooney, M Skinner, SJ Coker, S Currie British Journal of Pharmacology 172 (17), 4342-4354, 2015 | 22 | 2015 |
| The challenges of predicting drug-induced QTc prolongation in humans JP Valentin, P Hoffmann, C Ortemann-Renon, J Koerner, J Pierson, ... Toxicological Sciences 187 (1), 3-24, 2022 | 21 | 2022 |
| Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs L Mooney, L Marks, KL Philp, M Skinner, SJ Coker, S Currie Journal of pharmacological and toxicological methods 66 (1), 43-51, 2012 | 17 | 2012 |
| Detecting drug-induced prolongation of the QRS complex: new insights for cardiac safety assessment C Cros, M Skinner, J Moors, P Lainee, JP Valentin Toxicology and applied pharmacology 265 (2), 200-208, 2012 | 16 | 2012 |
| Effects of group housing on ECG assessment in conscious cynomolgus monkeys G Xing, J Lu, M Hu, S Wang, L Zhao, W Zheng, J Schofield, K Oldman, ... Journal of pharmacological and toxicological methods 75, 44-51, 2015 | 15 | 2015 |
| Evidence that central 5-HT1A receptors are involved in the vagal bradycardia evoked by aortic nerve stimulation in anaesthetised rabbits M Skinner, AG Ramage, D Jordan British Journal of Pharmacology 120, 25P-, 1997 | 4 | 1997 |
| Detecting drug-induced changes in ECG parameters using jacketed telemetry: Effect of different data reduction techniques M Skinner, G Xing, J Lu, J Ren, K Oldman Journal of Pharmacological and Toxicological Methods 85, 38-48, 2017 | 3 | 2017 |
| Echocardiography: a sensitive, clinically translatable biomarker for cardiac contractility CM Cooper, M Skinner, B Antrobus, S Brown, P Lainee, JP Valentin Journal of Pharmacological and Toxicological Methods 1 (64), e29, 2011 | 3 | 2011 |
| Effect of antagonism of central 5-HT1A receptors on baroreceptor and cardiopulmonary receptor reflexes in anaesthetized rabbits MR Skinner, AG Ramage, D Jordan Journal of Physiology 513, 85-, 1998 | 3 | 1998 |
