| The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes BM Ortmann, N Burrows, IT Lobb, E Arnaiz, N Wit, PSJ Bailey, LH Jordon, ... Nature genetics 53 (7), 1022-1035, 2021 | 44 | 2021 |
| mRNA cap methyltransferase, RNMT-RAM, promotes RNA Pol II-dependent transcription D Varshney, O Lombardi, G Schweikert, S Dunn, O Suska, VH Cowling Cell Reports 23 (5), 1530-1542, 2018 | 40 | 2018 |
| Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI V Lauer, S Grampp, J Platt, V Lafleur, O Lombardi, H Choudhry, F Kranz, ... Journal of Biological Chemistry 295 (13), 4065-4078, 2020 | 34 | 2020 |
| Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells S Dunn, O Lombardi, R Lukoszek, VH Cowling Open Biology 9 (4), 190052, 2019 | 21 | 2019 |
| c-Myc deregulation induces mRNA capping enzyme dependency O Lombardi, D Varshney, NM Phillips, VH Cowling Oncotarget 7 (50), 82273, 2016 | 17 | 2016 |
| Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer V Schmid, VN Lafleur, O Lombardi, R Li, R Salama, L Colli, H Choudhry, ... Scientific reports 9 (1), 18768, 2019 | 12 | 2019 |
| Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature O Lombardi, R Li, S Halim, H Choudhry, PJ Ratcliffe, DR Mole Cell Reports 41 (7), 2022 | 11 | 2022 |
| c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production S Dunn, O Lombardi, VH Cowling Biochemical Journal 474 (3), 377-384, 2017 | 9 | 2017 |
| Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI V Lauer, S Grampp, J Platt, V Lafleur, O Lombardi, H Choudhry, F Kranz, ... Journal of Biological Chemistry 295 (13), 2019 | 4 | 2019 |
| HIF pathways in clear cell renal cancer O Lombardi, DR Mole Biomarkers and Bioanalysis Overview, 2021 | 3 | 2021 |
| Transcriptional programs underpinning reoccurring cancer cell states, plasticity and tumour phylogenies in clear cell kidney cancer O Lombardi, R Li, L Browning, F Jabbar, H Evans, PJ Ratcliffe, DR Mole Cancer Research 84 (6_Supplement), 6944-6944, 2024 | | 2024 |
| Oncogenic cell tagging and single-cell transcriptomics reveal cell type-specific and time-resolved responses to Vhl inactivation in the kidney S Kurlekar, JDCC Lima, R Li, O Lombardi, N Masson, AB Barros, ... Cancer Research, 2024 | | 2024 |
| Multi region single cell sequencing reveals dedifferentiation programs, angiogenic heterogeneity and the effect of microenvironmental hypoxia in ccRCC tumors O Lombardi, R Li, L Browning, PJ Ratcliffe, DR Mole Cancer Research 82 (12_Supplement), 1587-1587, 2022 | | 2022 |
| Pan-cancer analysis of HIF pathways defines a robust molecular signature that reflects tissue and cellular hypoxia in bulk and single-cell RNA-seq analyses O Lombardi, R Li, S Halim, PJ Ratcliffe, DR Mole Cancer Research 82 (12_Supplement), 119-119, 2022 | | 2022 |
| Pan-cancer analysis of the HIF-transcriptional pathway and its association with genetic susceptibility to cancer DR Mole, V Schmid, O Lombardi, S Halim, VN Lafleur, R Li, R Salama, ... Cancer Research 80 (16_Supplement), 3436-3436, 2020 | | 2020 |
| Investigating the role of mRNA capping enzyme in C-MYC function O Lombardi University of Dundee, 2017 | | 2017 |
