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Dr Andrew S Butler
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An Update on the Structure of hERG
A Butler, MV Helliwell, Y Zhang, JC Hancox, CE Dempsey
Frontiers in pharmacology 10, 1572, 2020
692020
Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome
A Butler, Y Zhang, AG Stuart, CE Dempsey, JC Hancox
Physiological reports 6 (17), e13845, 2018
172018
Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome
A Butler, Y Zhang, AG Stuart, CE Dempsey, JC Hancox
Heliyon 5 (4), 2019
132019
Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome
JC Hancox, CY Du, A Butler, Y Zhang, CE Dempsey, SC Harmer, ...
Philosophical Transactions of the Royal Society B 378 (1879), 20220165, 2023
112023
The short QT syndrome
JC Hancox, MJ McPate, A El Harchi, AS Butler, Y Zhang, DG Whittaker, ...
Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation and …, 2023
82023
The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine
A El Harchi, AS Butler, Y Zhang, CE Dempsey, JC Hancox
Physiological Reports 8 (5), e14385, 2020
62020
Preferential formation of human heteromeric SK2: SK3 channels limits homomeric SK channel assembly and function
AS Butler, JC Hancox, NV Marrion
Journal of Biological Chemistry 299 (1), 2023
42023
Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling …
P Coppola, A Butler, S Cole, E Kerwash
Pharmaceutics 15 (10), 2455, 2023
22023
The entrainment of action potential duration and contraction amplitude by recapitulation of respiratory sinus arrhythmia in isolated cardiac myocytes
A Carpenter, LMK Pannell, ED Fowler, AS Butler, JFR Paton, JC Hancox, ...
Europace 26 (Supplement_1), euae102. 619, 2024
2024
In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition
AS Butler, R Ascione, NV Marrion, SC Harmer, JC Hancox
Scientific Reports 14 (1), 3185, 2024
2024
A single coiled‐coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1: hIKCa channels
JN Charlick, D Bozadzhieva, AS Butler, KA Wilkinson, NV Marrion
European Journal of Neuroscience 59 (1), 3-16, 2024
2024
Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells
SD Congreve, A Main, AS Butler, X Gao, E Brown, C Du, SC Choisy, ...
Frontiers in Physiology 14, 1163339, 2023
2023
The Short QT Syndrome 26
JC Hancox, MJ McPate, A El Harchi, AS Butler, Y Zhang, DG Whittaker, ...
Heart Rate and Rhythm, 517, 2023
2023
Development of IPSC-derived Human Cardiac Myocytes for the Targeting of SK Channels
AS Butler
University of Bristol, 2023
2023
Recapitulation of heart rate variability suppresses alternans in guinea pig ventricular myocytes
A Carpenter, AS Butler, LMK Pannell, JFR Paton, JC Hancox, AF James
ACTA PHYSIOLOGICA 236, 601-601, 2022
2022
Preferential assembly of human SK2 and SK3 subunits into heteromeric potassium channels reduces membrane expression of homomeric SK3 channels
AS Butler, JC Hancox, NV Marrion
ACTA PHYSIOLOGICA 236, 609-611, 2022
2022
Characterisation of two short QT syndrome potassium channel mutations
A Butler
University of Bristol, 2019
2019
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Articles 1–17