p53 and glucose metabolism: an orchestra to be directed in cancer therapy AS Gomes, H Ramos, J Soares, L Saraiva Pharmacological research 131, 75-86, 2018 | 118 | 2018 |
DIMP 53‐1: a novel small‐molecule dual inhibitor of p53–MDM 2/X interactions with multifunctional p53‐dependent anticancer properties J Soares, M Espadinha, L Raimundo, H Ramos, AS Gomes, S Gomes, ... Molecular Oncology 11 (6), 612-627, 2017 | 47 | 2017 |
New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma S Gomes, L Raimundo, J Soares, JB Loureiro, M Leao, H Ramos, ... Cancer letters 446, 90-102, 2019 | 44 | 2019 |
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule J Soares, L Raimundo, NAL Pereira, Â Monteiro, S Gomes, C Bessa, ... Oncotarget 7 (4), 4326, 2016 | 44 | 2016 |
Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53–MDM2 interaction M Leão, J Soares, S Gomes, L Raimundo, H Ramos, C Bessa, G Queiroz, ... Life sciences 142, 60-65, 2015 | 36 | 2015 |
A selective p53 activator and anticancer agent to improve colorectal cancer therapy H Ramos, MIL Soares, J Silva, L Raimundo, J Calheiros, C Gomes, F Reis, ... Cell Reports 35 (2), 2021 | 31 | 2021 |
SLMP53-1 inhibits tumor cell growth through regulation of glucose metabolism and angiogenesis in a P53-dependent manner H Ramos, J Calheiros, J Almeida, V Barcherini, S Santos, ATP Carvalho, ... International Journal of Molecular Sciences 21 (2), 596, 2020 | 24 | 2020 |
SLMP53-2 restores wild-type-like function to mutant p53 through Hsp70: promising activity in hepatocellular carcinoma S Gomes, B Bosco, JB Loureiro, H Ramos, L Raimundo, J Soares, ... Cancers 11 (8), 1151, 2019 | 24 | 2019 |
BRCA1/P53: Two strengths in cancer chemoprevention L Raimundo, H Ramos, JB Loureiro, J Calheiros, L Saraiva Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1873 (1), 188339, 2020 | 22 | 2020 |
p53 family interactions and yeast: together in anticancer therapy S Gomes, M Leao, L Raimundo, H Ramos, J Soares, L Saraiva Drug Discovery Today 21 (4), 616-624, 2016 | 17 | 2016 |
SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations AS Gomes, H Ramos, S Gomes, JB Loureiro, J Soares, V Barcherini, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1864 (1), 129440, 2020 | 16 | 2020 |
Naphthoylhydrazones: coordination to metal ions and biological screening N Ribeiro, AM Galvão, CSB Gomes, H Ramos, R Pinheiro, L Saraiva, ... New Journal of Chemistry 43 (45), 17801-17818, 2019 | 15 | 2019 |
A simple linearization method unveils hidden enzymatic assay interferences MF Pinto, J Ripoll-Rozada, H Ramos, EE Watson, C Franck, RJ Payne, ... Biophysical Chemistry 252, 106193, 2019 | 6 | 2019 |
Targeting neuroblastoma with a new inhibitor of the TAp73 interaction with MDM2 and mutant p53 L Raimundo, S Gomes, J Soares, J Loureiro, M Leão, H Ramos, ... MDPI AG, 2019 | | 2019 |
Strategies to Discover p53 Activators and a p73 Activator for Neuroblastoma E Sousa, S Gomes, L Raimundo, J Soares, J Loureiro, M Leão, H Ramos, ... Multidisciplinary Digital Publishing Institute Proceedings 22 (1), 56, 2019 | | 2019 |
Flavones: Promising Basis for Drug Devel-opment of Caspase Activators JP Moreira, H Ramos, S Salazar, MM Pinto, L Saraiva, H Cidade | | 2017 |
Uncovering the binding of the anticancer small molecule SLMP53-1 to mutant p53R280K AS Gomes, S Gomes, J Soares, H Ramos, C Oliveira, F Freire, B Pinheiro, ... | | 2017 |