John M Denu
John M Denu
Wisconsin Institute for Discovery, Professor of Biomolecular Chemistry,University of Wisconsin-Madison
Verified email at - Homepage
Cited by
Cited by
Histone acetyltransferases
SY Roth, JM Denu, CD Allis
Annual review of biochemistry 70 (1), 81-120, 2001
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
BJ North, BL Marshall, MT Borra, JM Denu, E Verdin
Molecular cell 11 (2), 437-444, 2003
Mechanism of human SIRT1 activation by resveratrol
MT Borra, BC Smith, JM Denu
Journal of Biological Chemistry 280 (17), 17187-17195, 2005
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
S Someya, W Yu, WC Hallows, J Xu, JM Vann, C Leeuwenburgh, ...
Cell 143 (5), 802-812, 2010
Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation
JM Denu, KG Tanner
Biochemistry 37 (16), 5633-5642, 1998
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
P Cheung, KG Tanner, WL Cheung, P Sassone-Corsi, JM Denu, CD Allis
Molecular cell 5 (6), 905-915, 2000
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
WC Hallows, S Lee, JM Denu
Proceedings of the National Academy of Sciences 103 (27), 10230-10235, 2006
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
KG Tanner, J Landry, R Sternglanz, JM Denu
Proceedings of the National Academy of Sciences 97 (26), 14178-14182, 2000
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
AS Hebert, KE Dittenhafer-Reed, W Yu, DJ Bailey, ES Selen, ...
Molecular cell 49 (1), 186-199, 2013
Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins*♦
JL Feldman, J Baeza, JM Denu
Journal of Biological Chemistry 288 (43), 31350-31356, 2013
Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice
CB Peek, AH Affinati, KM Ramsey, HY Kuo, W Yu, LA Sena, O Ilkayeva, ...
Science 342 (6158), 1243417, 2013
Protein tyrosine phosphatases: mechanisms of catalysis and regulation
JM Denu, JE Dixon
Current opinion in chemical biology 2 (5), 633-641, 1998
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
T Shimazu, MD Hirschey, L Hua, KE Dittenhafer-Reed, B Schwer, ...
Cell metabolism 12 (6), 654-661, 2010
Form and function in protein dephosphorylation
JM Denu, JA Stuckey, MA Saper, JE Dixon
Cell 87 (3), 361-364, 1996
Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues
KA Krautkramer, JH Kreznar, KA Romano, EI Vivas, GA Barrett-Wilt, ...
Molecular cell 64 (5), 982-992, 2016
Chemical mechanisms of histone lysine and arginine modifications
BC Smith, JM Denu
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1789 (1), 45-57, 2009
SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status*♦
W Yu, KE Dittenhafer-Reed, JM Denu
Journal of Biological Chemistry 287 (17), 14078-14086, 2012
Crystal structure of the dual specificity protein phosphatase VHR
J Yuvaniyama, JM Denu, JE Dixon, MA Saper
Science 272 (5266), 1328-1331, 1996
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
WC Hallows, W Yu, BC Smith, MK Devires, JJ Ellinger, S Someya, ...
Molecular cell 41 (2), 139-149, 2011
Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model
K Kasahara, KA Krautkramer, E Org, KA Romano, RL Kerby, EI Vivas, ...
Nature microbiology 3 (12), 1461-1471, 2018
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