Derek MacPherson
Derek MacPherson
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Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases-3,-6,-7, and-8
SJ Eron, DJ MacPherson, KB Dagbay, JA Hardy
ACS chemical biology 13 (5), 1279-1290, 2018
Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition
ME Hill, DJ MacPherson, P Wu, O Julien, JA Wells, JA Hardy
ACS chemical biology 11 (6), 1603-1612, 2016
Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry
T Dixon, D MacPherson, B Mostofian, T Dauzhenka, S Lotz, D McGee, ...
Nature communications 13 (1), 5884, 2022
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis
DJ MacPherson, CL Mills, MJ Ondrechen, JA Hardy
Journal of Biological Chemistry 294 (1), 71-88, 2019
A fluorescence-activatable reporter of flavivirus NS2BíVNS3 protease activity enables live imaging of infection in single cells and viral plaques
JL Arias-Arias, DJ MacPherson, ME Hill, JA Hardy, R Mora-Rodríguez
Journal of Biological Chemistry 295 (8), 2212-2226, 2020
Atomic-resolution prediction of degrader-mediated ternary complex structures by combining molecular simulations with hydrogen deuterium exchange
T Dixon, D MacPherson, B Mostofian, T Dauzhenka, S Lotz, D McGee, ...
Biorxiv, 2021.09. 26.461830, 2021
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