| An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion JD Klement, AV Paschall, PS Redd, ML Ibrahim, C Lu, D Yang, E Celis, ... The Journal of clinical investigation 128 (12), 5549-5560, 2018 | 213 | 2018 |
| Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes C Lu, JD Klement, ML Ibrahim, W Xiao, PS Redd, A Nayak-Kapoor, ... Journal for immunotherapy of cancer 7, 1-11, 2019 | 110 | 2019 |
| Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation HR Moorman, D Poschel, JD Klement, C Lu, PS Redd, K Liu Cancers 12 (11), 3379, 2020 | 93 | 2020 |
| Myeloid-derived suppressor cells produce IL-10 to elicit DNMT3b-dependent IRF8 silencing to promote colitis-associated colon tumorigenesis ML Ibrahim, JD Klement, C Lu, PS Redd, W Xiao, D Yang, DD Browning, ... Cell reports 25 (11), 3036-3046. e6, 2018 | 84 | 2018 |
| IFNAR1 controls autocrine type I IFN regulation of PD-L1 expression in myeloid-derived suppressor cells W Xiao, JD Klement, C Lu, ML Ibrahim, K Liu The Journal of Immunology 201 (1), 264-277, 2018 | 74 | 2018 |
| SETD1B activates iNOS expression in myeloid-derived suppressor cells PS Redd, ML Ibrahim, JD Klement, SK Sharman, AV Paschall, D Yang, ... Cancer research 77 (11), 2834-2843, 2017 | 59 | 2017 |
| Asah2 Represses the p53–Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis H Zhu, JD Klement, C Lu, PS Redd, D Yang, AD Smith, DB Poschel, J Zou, ... The Journal of Immunology 206 (6), 1395-1404, 2021 | 58 | 2021 |
| Autocrine IL6-Mediated Activation of the STAT3–DNMT Axis Silences the TNFα–RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells AD Smith, C Lu, D Payne, AV Paschall, JD Klement, PS Redd, ML Ibrahim, ... Cancer research 80 (15), 3145-3156, 2020 | 58 | 2020 |
| SUV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion C Lu, D Yang, JD Klement, IK Oh, NM Savage, JL Waller, AH Colby, ... Cancer immunology research 7 (3), 414-427, 2019 | 47 | 2019 |
| WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape C Lu, Z Liu, JD Klement, D Yang, AD Merting, D Poschel, T Albers, ... Journal for Immunotherapy of Cancer 9 (7), 2021 | 42 | 2021 |
| Loss of Fas Expression and Function Is Coupled with Colon Cancer Resistance to Immune Checkpoint Inhibitor Immunotherapy W Xiao, ML Ibrahim, PS Redd, JD Klement, C Lu, D Yang, NM Savage, ... Molecular Cancer Research 17 (2), 420-430, 2019 | 39 | 2019 |
| Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment JD Klement, PS Redd, C Lu, AD Merting, DB Poschel, D Yang, ... Cancer Cell 41 (3), 620-636. e9, 2023 | 38 | 2023 |
| MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment TW Mudd Jr, C Lu, JD Klement, K Liu Cellular Immunology 360, 104260, 2021 | 30 | 2021 |
| Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression JD Klement, DB Poschel, C Lu, AD Merting, D Yang, PS Redd, K Liu Cancers 13 (5), 1006, 2021 | 30 | 2021 |
| SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth C Lu, JD Klement, D Yang, T Albers, IO Lebedyeva, JL Waller, K Liu Cancer Letters 476, 87-96, 2020 | 26 | 2020 |
| Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells ML Ibrahim, C Lu, JD Klement, PS Redd, D Yang, AD Smith, K Liu Cancer Immunology, Immunotherapy 69, 2233-2245, 2020 | 20 | 2020 |
| H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells PS Redd, C Lu, JD Klement, ML Ibrahim, G Zhou, T Kumai, E Celis, K Liu OncoImmunology 7 (9), e1483302, 2018 | 16 | 2018 |
| p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy C Lu, JD Klement, AD Smith, D Yang, JL Waller, DD Browning, DH Munn, ... Journal for ImmunoTherapy of Cancer 8 (2), 2020 | 15 | 2020 |
| Lipid Nanoparticle Delivery of Fas Plasmid Restores Fas Expression to Suppress Melanoma Growth In Vivo ZY Al Subeh, DB Poschel, PS Redd, JD Klement, AD Merting, D Yang, ... ACS nano 16 (8), 12695-12710, 2022 | 14 | 2022 |
| G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes. C Lu, D Yang, JD Klement, YL Colson, NH Oberlies, CJ Pearce, AH Colby, ... Journal for Immunotherapy of Cancer 10 (1), 2022 | 12 | 2022 |
