| Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals) M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ... Journal of medicinal chemistry 61 (2), 482-491, 2018 | 300 | 2018 |
| Selective Sirt2 inhibition by ligand-induced rearrangement of the active site T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ... Nature communications 6 (1), 6263, 2015 | 282 | 2015 |
| Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies GG Kovács, L László, J Kovács, PH Jensen, E Lindersson, G Botond, ... Neurobiology of disease 17 (2), 155-162, 2004 | 173 | 2004 |
| Tubulin polymerization‐promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation A Lehotzky, P Lau, N Tőkési, N Muja, LD Hudson, J Ovádi Glia 58 (2), 157-168, 2010 | 142 | 2010 |
| TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6 N Tőkési, A Lehotzky, I Horváth, B Szabó, J Oláh, P Lau, J Ovádi Journal of Biological Chemistry 285 (23), 17896-17906, 2010 | 122 | 2010 |
| Interaction of phosphofructokinase with tubulin and microtubules. Quantitative evaluation of the mutual effects A Lehotzky, M Telegdi, K Liliom, J Ovadi Journal of Biological Chemistry 268 (15), 10888-10894, 1993 | 106 | 1993 |
| Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions O Vincze, N Tökési, J Oláh, E Hlavanda, Á Zotter, I Horváth, A Lehotzky, ... Biochemistry 45 (46), 13818-13826, 2006 | 96 | 2006 |
| Aminothiazoles as potent and selective Sirt2 inhibitors: a structure–activity relationship study M Schiedel, T Rumpf, B Karaman, A Lehotzky, J Oláh, S Gerhardt, J Ovádi, ... Journal of medicinal chemistry 59 (4), 1599-1612, 2016 | 94 | 2016 |
| Dynamic targeting of microtubules by TPPP/p25 affects cell survival A Lehotzky, L Tirián, N Tokesi, P Lénárt, B Szabó, J Kovács, J Ovádi Journal of cell science 117 (25), 6249-6259, 2004 | 87 | 2004 |
| The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases GG Kovács, E Gelpi, A Lehotzky, R Höftberger, A Erdei, H Budka, J Ovádi Acta Neuropathologica 113, 153-161, 2007 | 73 | 2007 |
| TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments F Orosz, GG Kovács, A Lehotzky, J Oláh, O Vincze, J Ovádi Biology of the Cell 96 (9), 701-711, 2004 | 70 | 2004 |
| Structure‐based development of an affinity probe for Sirtuin 2 M Schiedel, T Rumpf, B Karaman, A Lehotzky, S Gerhardt, J Ovádi, ... Angewandte Chemie International Edition 55 (6), 2252-2256, 2016 | 66 | 2016 |
| Interaction of TPPP/p25 protein with glyceraldehyde‐3‐phosphate dehydrogenase and their co‐localization in Lewy bodies J Oláh, N Tőkési, O Vincze, I Horváth, A Lehotzky, A Erdei, E Szájli, ... FEBS letters 580 (25), 5807-5814, 2006 | 42 | 2006 |
| Pyruvate Kinase as a Microtubule Destabilizing Factorin Vitro BG Vértessy, D Bánkfalvi, J Kovács, P Löw, A Lehotzky, J Ovádi Biochemical and biophysical research communications 254 (2), 430-435, 1999 | 40 | 1999 |
| Microtubule-associated proteins with regulatory functions by day and pathological potency at night J Oláh, A Lehotzky, S Szunyogh, T Szénási, F Orosz, J Ovádi Cells 9 (2), 357, 2020 | 35 | 2020 |
| Characterization of microtubule− phosphofructokinase complex: specific effects of MgATP and vinblastine BG Vértessy, J Kovács, P Löw, A Lehotzky, A Molnár, F Orosz, J Ovádi Biochemistry 36 (8), 2051-2062, 1997 | 35 | 1997 |
| TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells M Preusser, A Lehotzky, H Budka, J Ovádi, GG Kovács Acta neuropathologica 113, 213-215, 2007 | 34 | 2007 |
| New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2 S Swyter, M Schiedel, D Monaldi, S Szunyogh, A Lehotzky, T Rumpf, ... Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018 | 32 | 2018 |
| Ligand-modulated cross-bridging of microtubules by phosphofructokinase A Lehotzky, Z Palfia, J Kovacs, A Molnar, J Ovadi Biochemical and biophysical research communications 204 (2), 585-591, 1994 | 30 | 1994 |
| Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins T Szénási, J Oláh, A Szabó, S Szunyogh, A Láng, A Perczel, A Lehotzky, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (1), 310-323, 2017 | 28 | 2017 |
Manfred JungInstitute of Pharmaceutical Sciences, University of Freiburg; former University of Münster, OttawaVerified email at pharmazie.uni-freiburg.de
