Nicolas Arbez
Nicolas Arbez
Johns Hopkins school of medicine
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Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes
Hd iPsc Consortium
Cell stem cell 11 (2), 264-278, 2012
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
M Jiang, J Wang, J Fu, L Du, H Jeong, T West, L Xiang, Q Peng, Z Hou, ...
Nature medicine 18 (1), 153-158, 2012
Mutant huntingtin disrupts the nuclear pore complex
JC Grima, JG Daigle, N Arbez, KC Cunningham, KE Zhang, J Ochaba, ...
Neuron 94 (1), 93-107. e6, 2017
trans-(−)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington disease
J Fu, J Jin, RH Cichewicz, SA Hageman, TK Ellis, L Xiang, Q Peng, ...
Journal of Biological Chemistry 287 (29), 24460-24472, 2012
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Nature neuroscience 20 (5), 648-660, 2017
Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis
T Ratovitski, E Chighladze, N Arbez, T Boronina, S Herbrich, RN Cole, ...
Cell Cycle 11 (10), 2006-2021, 2012
Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein
LG Nucifora, KA Burke, X Feng, N Arbez, S Zhu, J Miller, G Yang, ...
Journal of Biological Chemistry 287 (19), 16017-16028, 2012
Aβ (25–35) and Aβ (1–40) act on different calcium channels in CA1 hippocampal neurons
C Rovira, N Arbez, J Mariani
Biochemical and Biophysical Research Communications 296 (5), 1317-1321, 2002
Activation of the JNK–c‐Jun pathway during the early phase of neuronal apoptosis induced by PrP106–126 and prion infection
J Carimalo, S Cronier, G Petit, JM Peyrin, F Boukhtouche, N Arbez, ...
European Journal of Neuroscience 21 (9), 2311-2319, 2005
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically
AS Dickey, VV Pineda, T Tsunemi, PP Liu, HC Miranda, SK Gilmore-Hall, ...
Nature medicine 22 (1), 37-45, 2016
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
FC Nucifora Jr, LG Nucifora, CH Ng, N Arbez, Y Guo, E Roby, V Shani, ...
Nature communications 7 (1), 11792, 2016
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin
E Waldron-Roby, T Ratovitski, XF Wang, M Jiang, E Watkin, N Arbez, ...
Journal of Neuroscience 32 (1), 183-193, 2012
LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin
D Yang, T Li, Z Liu, N Arbez, J Yan, TH Moran, CA Ross, WW Smith
Neurobiology of disease 47 (3), 385-392, 2012
PRMT5-mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)
T Ratovitski, N Arbez, JC Stewart, E Chighladze, CA Ross
Cell Cycle 14 (11), 1716-1729, 2015
IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?
S Willaime-Morawek, N Arbez, J Mariani, B Brugg
Molecular brain research 142 (2), 97-106, 2005
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
AS Dickey, DN Sanchez, M Arreola, KR Sampat, W Fan, N Arbez, ...
Science translational medicine 9 (419), eaal2332, 2017
Post-translational modifications (PTMs), identified on endogenous huntingtin, cluster within proteolytic domains between HEAT repeats
T Ratovitski, RN O’Meally, M Jiang, R Chaerkady, E Chighladze, ...
Journal of proteome research 16 (8), 2692-2708, 2017
ATXN2‐AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis
PP Li, X Sun, G Xia, N Arbez, S Paul, S Zhu, HB Peng, CA Ross, ...
Annals of neurology 80 (4), 600-615, 2016
Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB …
G Barthet, J Dunys, Z Shao, Z Xuan, Y Ren, J Xu, N Arbez, G Mauger, ...
Neurobiology of aging 34 (2), 499-510, 2013
Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity
N Arbez, T Ratovitski, E Roby, E Chighladze, JC Stewart, M Ren, X Wang, ...
Journal of Biological Chemistry 292 (47), 19238-19249, 2017
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