| Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes Hd iPsc Consortium Cell stem cell 11 (2), 264-278, 2012 | 454 | 2012 |
| Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets M Jiang, J Wang, J Fu, L Du, H Jeong, T West, L Xiang, Q Peng, Z Hou, ... Nature medicine 18 (1), 153-158, 2012 | 337 | 2012 |
| Mutant huntingtin disrupts the nuclear pore complex JC Grima, JG Daigle, N Arbez, KC Cunningham, KE Zhang, J Ochaba, ... Neuron 94 (1), 93-107. e6, 2017 | 269 | 2017 |
| trans-(−)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington disease J Fu, J Jin, RH Cichewicz, SA Hageman, TK Ellis, L Xiang, Q Peng, ... Journal of Biological Chemistry 287 (29), 24460-24472, 2012 | 168 | 2012 |
| Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice Nature neuroscience 20 (5), 648-660, 2017 | 162 | 2017 |
| Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis T Ratovitski, E Chighladze, N Arbez, T Boronina, S Herbrich, RN Cole, ... Cell Cycle 11 (10), 2006-2021, 2012 | 124 | 2012 |
| Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein LG Nucifora, KA Burke, X Feng, N Arbez, S Zhu, J Miller, G Yang, ... Journal of Biological Chemistry 287 (19), 16017-16028, 2012 | 122 | 2012 |
| Aβ (25–35) and Aβ (1–40) act on different calcium channels in CA1 hippocampal neurons C Rovira, N Arbez, J Mariani Biochemical and Biophysical Research Communications 296 (5), 1317-1321, 2002 | 104 | 2002 |
| Activation of the JNK–c‐Jun pathway during the early phase of neuronal apoptosis induced by PrP106–126 and prion infection J Carimalo, S Cronier, G Petit, JM Peyrin, F Boukhtouche, N Arbez, ... European Journal of Neuroscience 21 (9), 2311-2319, 2005 | 82 | 2005 |
| PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically AS Dickey, VV Pineda, T Tsunemi, PP Liu, HC Miranda, SK Gilmore-Hall, ... Nature medicine 22 (1), 37-45, 2016 | 81 | 2016 |
| Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1 FC Nucifora Jr, LG Nucifora, CH Ng, N Arbez, Y Guo, E Roby, V Shani, ... Nature communications 7 (1), 11792, 2016 | 68 | 2016 |
| Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin E Waldron-Roby, T Ratovitski, XF Wang, M Jiang, E Watkin, N Arbez, ... Journal of Neuroscience 32 (1), 183-193, 2012 | 61 | 2012 |
| LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin D Yang, T Li, Z Liu, N Arbez, J Yan, TH Moran, CA Ross, WW Smith Neurobiology of disease 47 (3), 385-392, 2012 | 57 | 2012 |
| PRMT5-mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD) T Ratovitski, N Arbez, JC Stewart, E Chighladze, CA Ross Cell Cycle 14 (11), 1716-1729, 2015 | 55 | 2015 |
| IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2? S Willaime-Morawek, N Arbez, J Mariani, B Brugg Molecular brain research 142 (2), 97-106, 2005 | 51 | 2005 |
| PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis AS Dickey, DN Sanchez, M Arreola, KR Sampat, W Fan, N Arbez, ... Science translational medicine 9 (419), eaal2332, 2017 | 49 | 2017 |
| Post-translational modifications (PTMs), identified on endogenous huntingtin, cluster within proteolytic domains between HEAT repeats T Ratovitski, RN O’Meally, M Jiang, R Chaerkady, E Chighladze, ... Journal of proteome research 16 (8), 2692-2708, 2017 | 49 | 2017 |
| ATXN2‐AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis PP Li, X Sun, G Xia, N Arbez, S Paul, S Zhu, HB Peng, CA Ross, ... Annals of neurology 80 (4), 600-615, 2016 | 49 | 2016 |
| Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB … G Barthet, J Dunys, Z Shao, Z Xuan, Y Ren, J Xu, N Arbez, G Mauger, ... Neurobiology of aging 34 (2), 499-510, 2013 | 46 | 2013 |
| Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity N Arbez, T Ratovitski, E Roby, E Chighladze, JC Stewart, M Ren, X Wang, ... Journal of Biological Chemistry 292 (47), 19238-19249, 2017 | 44 | 2017 |
