Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity J Lai, S Mardiana, IG House, K Sek, MA Henderson, L Giuffrida, ... Nature immunology 21 (8), 914-926, 2020 | 140 | 2020 |
Cellular networks controlling T cell persistence in adoptive cell therapy JD Chan, J Lai, CY Slaney, A Kallies, PA Beavis, PK Darcy Nature Reviews Immunology 21 (12), 769-784, 2021 | 115 | 2021 |
MAIT cells regulate NK cell-mediated tumor immunity EV Petley, HF Koay, MA Henderson, K Sek, KL Todd, SP Keam, J Lai, ... Nature communications 12 (1), 4746, 2021 | 51 | 2021 |
Genetic redirection of T cells for the treatment of pancreatic cancer AI Ali, AJ Oliver, T Samiei, JD Chan, MH Kershaw, CY Slaney Frontiers in oncology 9, 56, 2019 | 47 | 2019 |
Tissue‐specific tumor microenvironments influence responses to immunotherapies AJ Oliver, AS Davey, SP Keam, S Mardiana, JD Chan, B von Scheidt, ... Clinical & translational immunology 8 (11), e1094, 2019 | 27 | 2019 |
Enterotoxins can support CAR T cells against solid tumors B von Scheidt, M Wang, AJ Oliver, JD Chan, MK Jana, AI Ali, F Clow, ... Proceedings of the National Academy of Sciences 116 (50), 25229-25235, 2019 | 24 | 2019 |
Enhancing chimeric antigen receptor T‐cell immunotherapy against cancer using a nanoemulsion‐based vaccine targeting cross‐presenting dendritic cells JD Chan, B von Scheidt, B Zeng, AJ Oliver, AS Davey, AI Ali, R Thomas, ... Clinical & translational immunology 9 (7), e1157, 2020 | 22 | 2020 |
A histone deacetylase inhibitor, panobinostat, enhances chimeric antigen receptor T-cell antitumor effect against pancreatic cancer AI Ali, M Wang, B von Scheidt, PM Dominguez, AJ Harrison, DGM Tantalo, ... Clinical Cancer Research 27 (22), 6222-6234, 2021 | 19 | 2021 |
p38 Kinase: a key target for driving potent T cells for adoptive immunotherapy JD Chan, PA Beavis, PK Darcy Cancer cell 37 (6), 756-758, 2020 | 4 | 2020 |
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity IG House, EB Derrick, K Sek, AXY Chen, J Li, J Lai, KL Todd, I Munoz, ... Cell reports 42 (8), 2023 | 3 | 2023 |
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy JD Chan, CM Scheffler, I Munoz, K Sek, JN Lee, YK Huang, KM Yap, ... Nature, 1-10, 2024 | 1 | 2024 |
Chimeric antigen receptor T cell therapies for thoracic cancers—challenges and opportunities JD Chan, AJ Harrison, PK Darcy, MH Kershaw, CY Slaney Journal of Thoracic Disease 12 (8), 4510, 2020 | 1 | 2020 |
Tumor-site directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors P Darcy, K Sek, A Chen, T Cole, J Armitage, J Tong, KM Yap, I Munoz, ... | | 2024 |
A Rare Cell State Underpins Diverse Mechanisms of Adaptive Resistance to CAR T-Cell Therapy in B-Cell Acute Lymphoblastic Leukemia JA Kuzich, L Talarmain, D Vassiliadis, AA Guirguis, JD Chan, PA Beavis, ... Blood 142, 887, 2023 | | 2023 |
Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors P Beavis, P Darcy, J Lai, J Chan, K Sek, C Scheffler, I Munoz, YK Huang, ... | | 2023 |
Enhancing CAR T cell therapy by enabling their interaction with antigen-presenting cells CY Slaney, P Wang, JD Chan, PK Darcy, MH Kershaw EUROPEAN JOURNAL OF IMMUNOLOGY 49, 1711-1711, 2019 | | 2019 |