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Yannick Kok
Yannick Kok
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Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient …
PM Schoonen, YP Kok, E Wierenga, B Bakker, F Foijer, DCJ Spierings, ...
Molecular oncology 13 (11), 2422-2440, 2019
802019
Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors
YP Kok, S Guerrero Llobet, PM Schoonen, M Everts, A Bhattacharya, ...
Oncogenesis 9 (10), 88, 2020
562020
TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells
SE van Gijn, E Wierenga, N van den Tempel, YP Kok, AM Heijink, ...
Oncogene 38 (6), 852-867, 2019
542019
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability
ME Geijer, D Zhou, K Selvam, B Steurer, C Mukherjee, B Evers, S Cugusi, ...
Nature cell biology 23 (6), 608-619, 2021
522021
Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies
C Stok, YP Kok, N van den Tempel, MATM van Vugt
Nucleic acids research 49 (8), 4239-4257, 2021
512021
Modeling of cisplatin-induced signaling dynamics in triple-negative breast cancer cells reveals mediators of sensitivity
AM Heijink, M Everts, ME Honeywell, R Richards, YP Kok, EGE de Vries, ...
Cell reports 28 (9), 2345-2357. e5, 2019
312019
Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51
AM Heijink, C Stok, D Porubsky, EM Manolika, JK de Kanter, YP Kok, ...
Nature Communications 13 (1), 6722, 2022
232022
The H3. 3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma
I Bočkaj, TEI Martini, ES de Camargo Magalhães, PL Bakker, ...
PLoS genetics 17 (11), e1009868, 2021
182021
FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics
C Stok, S Tsaridou, N van den Tempel, M Everts, E Wierenga, FJ Bakker, ...
Cell reports 42 (7), 2023
72023
Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors
AM Heijink, C Stok, D Porubsky, EM Manolika, YP Kok, M Everts, ...
Biorxiv, 2021.09. 17.460736, 2021
42021
The FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin
C Stok, N van den Tempel, M Everts, E Wierenga, F Bakker, Y Kok, ...
bioRxiv, 2022.10. 07.511242, 2022
12022
Causes and consequences of mitotic DNA damage
Y Kok
12022
PPM1D activity promotes the replication stress caused by cyclin E1 overexpression
AS Martinikova, M Stoyanov, A Oravetzova, YP Kok, S Yu, J Dobrovolna, ...
Molecular oncology 18 (1), 6-20, 2024
2024
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Articles 1–13