| Mechanisms of action of glucagon-like peptide 1 in the pancreas ME Doyle, JM Egan Pharmacology & therapeutics 113 (3), 546-593, 2007 | 873 | 2007 |
| Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats R Perfetti, JIE Zhou, ME Doyle, JM Egan Endocrinology 141 (12), 4600-4605, 2000 | 580 | 2000 |
| Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP MJ Theodorakis, O Carlson, S Michopoulos, ME Doyle, M Juhaszova, ... American Journal of Physiology-Endocrinology and Metabolism 290 (3), E550-E559, 2006 | 483 | 2006 |
| Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats M Szayna, ME Doyle, JA Betkey, HW Holloway, RGS Spencer, NH Greig, ... Endocrinology 141 (6), 1936-1941, 2000 | 437 | 2000 |
| Pharmacological agents that directly modulate insulin secretion ME Doyle, JM Egan Pharmacological reviews 55 (1), 105-131, 2003 | 325 | 2003 |
| Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic β-cells by a cyclic adenosine monophosphate … X Wang, J Zhou, ME Doyle, JM Egan Endocrinology 142 (5), 1820-1827, 2001 | 203 | 2001 |
| Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells X Wang, CM Cahill, MA Piñeyro, J Zhou, ME Doyle, JM Egan Endocrinology 140 (10), 4904-4907, 1999 | 200 | 1999 |
| Glucagon-like peptide-1. ME Doyle, JM Egan Recent progress in hormone research 56, 377-399, 2001 | 170 | 2001 |
| Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet JL Fiori, YK Shin, W Kim, SM Krzysik-Walker, I González-Mariscal, ... Diabetes 62 (10), 3500-3513, 2013 | 156 | 2013 |
| Exendin‐4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX‐1 and HNF3β transcription factors J Zhou, MA Pineyro, X Wang, ME Doyle, JM Egan Journal of cellular physiology 192 (3), 304-314, 2002 | 147 | 2002 |
| Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells W Kim, ME Doyle, Z Liu, Q Lao, YK Shin, OD Carlson, HS Kim, S Thomas, ... Diabetes 60 (4), 1198-1209, 2011 | 137 | 2011 |
| Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease M Airavaara, O Pletnikova, ME Doyle, YE Zhang, JC Troncoso, QR Liu Journal of Biological Chemistry 286 (52), 45093-45102, 2011 | 124 | 2011 |
| Human CB1 receptor isoforms, present in hepatocytes and β-cells, are involved in regulating metabolism I González-Mariscal, SM Krzysik-Walker, ME Doyle, QR Liu, R Cimbro, ... Scientific reports 6 (1), 33302, 2016 | 113 | 2016 |
| The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity ME Doyle, MJ Theodorakis, HW Holloway, M Bernier, NH Greig, JM Egan Regulatory peptides 114 (2-3), 153-158, 2003 | 73 | 2003 |
| Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). EJM Doyle ME, Appleton A, Liu QR, Yao Q, Mazucanti CH American Journal of Pathology, 2021 | 69 | 2021 |
| Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets I González-Mariscal, RA Montoro, ME Doyle, QR Liu, M Rouse, ... Diabetologia 61, 1470-1483, 2018 | 58 | 2018 |
| GLP-1 exendin-4 peptide analogs and uses thereof N Greig, J Egan, M Doyle, H Holloway, TA Perry US Patent 7,576,050, 2009 | 53 | 2009 |
| Sjögren's syndrome‐like disease of C57BL/6. NOD‐Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross‐over in the chromosome 3 Aec1 locus C Nguyen, E Singson, JY Kim, JG Cornelius, R Attia, ME Doyle, ... Scandinavian journal of immunology 64 (3), 295-307, 2006 | 51 | 2006 |
| Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition ME Doyle, L Boggs, R Attia, LR Cooper, DR Saban, CQ Nguyen, AB Peck The American journal of pathology 171 (4), 1224-1236, 2007 | 49 | 2007 |
| Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent ME Doyle, NH Greig, HW Holloway, JA Betkey, M Bernier, JM Egan Endocrinology 142 (10), 4462-4468, 2001 | 47 | 2001 |
NIGEL GREIGChief, Drug Design & Development Section, National Institute on Aging, NIHVerified email at grc.nia.nih.gov
