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Katy Sutcliffe
Katy Sutcliffe
University of Bristol
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Year
The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception
R Hill, A Disney, A Conibear, K Sutcliffe, W Dewey, S Husbands, C Bailey, ...
British journal of pharmacology 175 (13), 2653-2661, 2018
1812018
The anomalous pharmacology of fentanyl
E Kelly, K Sutcliffe, D Cavallo, N Ramos‐Gonzalez, N Alhosan, ...
British journal of pharmacology 180 (7), 797-812, 2023
532023
A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor
Z Dekan, S Sianati, A Yousuf, KJ Sutcliffe, A Gillis, C Mallet, P Singh, ...
Proceedings of the National Academy of Sciences 116 (44), 22353-22358, 2019
412019
Drug binding poses relate structure with efficacy in the μ opioid receptor
KJ Sutcliffe, G Henderson, E Kelly, RB Sessions
Journal of molecular biology 429 (12), 1840-1851, 2017
332017
Interaction with the lipid membrane influences fentanyl pharmacology
KJ Sutcliffe, RA Corey, N Alhosan, D Cavallo, S Groom, M Santiago, ...
Advances in drug and alcohol research 2, 10280, 2022
102022
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR
J Liu, AP Berg, Y Wang, W Jantarajit, KJ Sutcliffe, EB Stevens, L Cao, ...
British Journal of Pharmacology 179 (7), 1319-1337, 2022
92022
CFTR modulators: from mechanism to targeted therapeutics
HI Yeh, KJ Sutcliffe, DN Sheppard, TC Hwang
62022
Fentanyl binds to the μ-opioid receptor via the lipid membrane and transmembrane helices
KJ Sutcliffe, RA Corey, SJ Charlton, RB Sessions, G Henderson, E Kelly
BiorXiv, 2021.02. 04.429703, 2021
42021
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor
N Ramos‐Gonzalez, S Groom, KJ Sutcliffe, S Bancroft, CP Bailey, ...
British Journal of Pharmacology 180 (18), 2341-2360, 2023
32023
EPS3. 07 Mapping ivacaftor-induced structural changes in CFTR with computer simulations
DF Veselu, KJ Sutcliffe, DK Shoemark, I Callebaut, DN Sheppard, ...
Journal of Cystic Fibrosis 22, S44-S45, 2023
2023
Exploring the signalling bias and efficacy of carfentanil
N Ramos-Gonzalez, S Groom, K Sutcliffe, S Bancroft, C Bailey, ...
BRITISH JOURNAL OF PHARMACOLOGY 180 (4), 486-488, 2023
2023
Carfentanil is an arrestin-biased agonist at the mu opioid receptor
N Ramos-Gonzalez, S Groom, S Bancroft, K Sutcliffe, C Bailey, ...
BRITISH JOURNAL OF PHARMACOLOGY 178 (24), 4941-4942, 2021
2021
Fentanyl binds to the mu-opioid receptor via the lipid bilayer and transmembrane helices
K Sutcliffe, R Corey, S Charlton, R Sessions, G Henderson, E Kelly
BRITISH JOURNAL OF PHARMACOLOGY 178 (24), 4970-4972, 2021
2021
More than one potential binding pose for fentanyl in the mu-opioid receptor identified with molecular dynamics simulations
N Ramos-Gonzalez, KJ Sutcliffe, S Bancroft, G Henderson, RB Sessions, ...
BRITISH JOURNAL OF PHARMACOLOGY 178 (2), 440-441, 2021
2021
Molecular dynamic simulations of morphine in the active and inactive mu-opioid receptor
N Ramos-Gonzalez, KJ Sutcliffe, G Henderson, E Kelly, RB Sessions
BRITISH JOURNAL OF PHARMACOLOGY 177 (11), 2531-2532, 2020
2020
Molecular Dynamics Simulations and Mutagenesis to Identify the Mechanisms of Ligand Efficacy and Bias at the μ Opioid Receptor
K Sutcliffe
University of Bristol (United Kingdom), 2020
2020
Novel mechanism of fentanyl binding to the mu-opioid receptor revealed by molecular dynamic simulations
SK Bancroft, K Sutcliffe, G Henderson, R Sessions, E Kelly
BRITISH JOURNAL OF PHARMACOLOGY 176 (16), 3029-3030, 2019
2019
Identifying a molecular basis for opioid ligand efficacy and bias
KJ Sutcliffe, G Henderson, E Kelly, RB Sessions
BRITISH JOURNAL OF PHARMACOLOGY 176 (16), 3025-3025, 2019
2019
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