The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception R Hill, A Disney, A Conibear, K Sutcliffe, W Dewey, S Husbands, C Bailey, ... British journal of pharmacology 175 (13), 2653-2661, 2018 | 181 | 2018 |
The anomalous pharmacology of fentanyl E Kelly, K Sutcliffe, D Cavallo, N Ramos‐Gonzalez, N Alhosan, ... British journal of pharmacology 180 (7), 797-812, 2023 | 53 | 2023 |
A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor Z Dekan, S Sianati, A Yousuf, KJ Sutcliffe, A Gillis, C Mallet, P Singh, ... Proceedings of the National Academy of Sciences 116 (44), 22353-22358, 2019 | 41 | 2019 |
Drug binding poses relate structure with efficacy in the μ opioid receptor KJ Sutcliffe, G Henderson, E Kelly, RB Sessions Journal of molecular biology 429 (12), 1840-1851, 2017 | 33 | 2017 |
Interaction with the lipid membrane influences fentanyl pharmacology KJ Sutcliffe, RA Corey, N Alhosan, D Cavallo, S Groom, M Santiago, ... Advances in drug and alcohol research 2, 10280, 2022 | 10 | 2022 |
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR J Liu, AP Berg, Y Wang, W Jantarajit, KJ Sutcliffe, EB Stevens, L Cao, ... British Journal of Pharmacology 179 (7), 1319-1337, 2022 | 9 | 2022 |
CFTR modulators: from mechanism to targeted therapeutics HI Yeh, KJ Sutcliffe, DN Sheppard, TC Hwang | 6 | 2022 |
Fentanyl binds to the μ-opioid receptor via the lipid membrane and transmembrane helices KJ Sutcliffe, RA Corey, SJ Charlton, RB Sessions, G Henderson, E Kelly BiorXiv, 2021.02. 04.429703, 2021 | 4 | 2021 |
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor N Ramos‐Gonzalez, S Groom, KJ Sutcliffe, S Bancroft, CP Bailey, ... British Journal of Pharmacology 180 (18), 2341-2360, 2023 | 3 | 2023 |
EPS3. 07 Mapping ivacaftor-induced structural changes in CFTR with computer simulations DF Veselu, KJ Sutcliffe, DK Shoemark, I Callebaut, DN Sheppard, ... Journal of Cystic Fibrosis 22, S44-S45, 2023 | | 2023 |
Exploring the signalling bias and efficacy of carfentanil N Ramos-Gonzalez, S Groom, K Sutcliffe, S Bancroft, C Bailey, ... BRITISH JOURNAL OF PHARMACOLOGY 180 (4), 486-488, 2023 | | 2023 |
Carfentanil is an arrestin-biased agonist at the mu opioid receptor N Ramos-Gonzalez, S Groom, S Bancroft, K Sutcliffe, C Bailey, ... BRITISH JOURNAL OF PHARMACOLOGY 178 (24), 4941-4942, 2021 | | 2021 |
Fentanyl binds to the mu-opioid receptor via the lipid bilayer and transmembrane helices K Sutcliffe, R Corey, S Charlton, R Sessions, G Henderson, E Kelly BRITISH JOURNAL OF PHARMACOLOGY 178 (24), 4970-4972, 2021 | | 2021 |
More than one potential binding pose for fentanyl in the mu-opioid receptor identified with molecular dynamics simulations N Ramos-Gonzalez, KJ Sutcliffe, S Bancroft, G Henderson, RB Sessions, ... BRITISH JOURNAL OF PHARMACOLOGY 178 (2), 440-441, 2021 | | 2021 |
Molecular dynamic simulations of morphine in the active and inactive mu-opioid receptor N Ramos-Gonzalez, KJ Sutcliffe, G Henderson, E Kelly, RB Sessions BRITISH JOURNAL OF PHARMACOLOGY 177 (11), 2531-2532, 2020 | | 2020 |
Molecular Dynamics Simulations and Mutagenesis to Identify the Mechanisms of Ligand Efficacy and Bias at the μ Opioid Receptor K Sutcliffe University of Bristol (United Kingdom), 2020 | | 2020 |
Novel mechanism of fentanyl binding to the mu-opioid receptor revealed by molecular dynamic simulations SK Bancroft, K Sutcliffe, G Henderson, R Sessions, E Kelly BRITISH JOURNAL OF PHARMACOLOGY 176 (16), 3029-3030, 2019 | | 2019 |
Identifying a molecular basis for opioid ligand efficacy and bias KJ Sutcliffe, G Henderson, E Kelly, RB Sessions BRITISH JOURNAL OF PHARMACOLOGY 176 (16), 3025-3025, 2019 | | 2019 |